Posted on 09/09/2021 6:58:17 AM PDT by numberonepal
Niacin and Melatonin work in synergy. The melatonin opens the gateway to cells and the inflammation within the cells. Niacin gets inside and kicks the crap out of it. We are all depleted of melatonin, so everyone's doses are different.
The Sweet Spot is when there is No Flush. Not even a tingle occurs. Hence, all the melatonin is being used up as well as the niacin to remove inflammation and restore the cells to homeostasis. The Flush is when excess niacin is not being used by the melatonin and goes to the skin capillaries.
The environmental stresses of modern life can lead to shortages of nutrients, especially melatonin and niacin, leading to the accumulation of free radicals and inflammation. The virus was targeted to affect the ACE2 receptors, which are regulated by melatonin and niacin. Once in your cells the virus consumes your energy, depletes melatonin, down-regulates the ACE2 receptors (especially in the intestines producing a leaky gut) giving the virus and spikes easy access to your brain and nervous system through the Vagus nerve.
The virus thrives in a melatonin/niacin deficient environment. The virus uses the energy from inflammation for its fitness (fuel). Supplementing melatonin and niacin reduces the inflammation that makes your body more vulnerable and reactivates your immune system to take care of the virus.
Over the course of life the lack of nutrients, especially melatonin and niacin, can't counter the progression of bad health behaviors throughout that life. New exposures like electronics, geothermal shifts, etc, a stressful life and poorer quality food these days all compound these deficiencies. Our continued dynamic deficiency in especially NIATONIN (niacin/melatonin) leads to the accumulation of more energy not expended out as per in. Because of this free radical electrons form and inflammation accumulates.
It's literally like the virus and covid pathogenesis, just slower.
These viruses or their gain of function research - whatever you want to imagine it is - have evolved since SARS-1 in 2000 to target these energy receptors; aka ACE2; what niacin and melatonin regulate.
It's a feasting ground for them (viruses).
Note:
Niacin and melatonin regulate ACE2 (Angiotensin-converting enzyme 2).
ACE2 is an enzyme attached to the membrane of cells located in the intestines, kidney, testis, gallbladder, and heart. ACE2 lowers blood pressure by catalyzing the hydrolysis of angiotensin II into angiotensin.
They're (viruses) thermodynamically attracted to people who have more inflammation for them to use for their fitness (fuel). These high expressed ACE2 (aka niacin receptors) along with the SR-B1 coreceptor right next to it - they (virus) sneak in this.
Note:
SR-B1 is a scavenger receptor class B type 1. It functions as a receptor for high-density lipoprotein. It is also know as CD36, a scavenger receptor class B member 3.
SR-BI/CD36 chimeric receptors define extracellular subdomains of SR-BI critical for cholesterol transport
https://pubmed.ncbi.nlm.nih.gov/25211142/
The SR-B1 is where HDL dumps off cholesterol from blood into tissue to prevent atherosclerosis. Because the cholesterol was leaking out of the tissue after it reached threshold, it can not contain it anymore due to too much pressure. As a result, HDL lowers because it's not getting developed in the liver anymore. The HDL has to attend to scooping more cholesterol back into tissue, and is used up real quick.
The virus then gets in cells and as it literally continues to consume your energy until it reaches a threshold it needs of energy to double (replicate). As it does this it depletes melatonin. It also makes it a lot easier if you have deficient melatonin. You can see now why unhealthy and older people who have not had enough melatonin and niacin as most at risk. They also have low HDL/high TG (triglycerides). The depleted melatonin makes the PDC receptor, already stunted from accumulated inflammation over a lifetime, from pyruvate to Acetyl-CoA even more stunted. Due to this melatonin gets gradually even more depleted into say long haul COVID. As soon as the virus meets threshold to replicate it moves out the mitochondria, and on to the next one (cell) like a bad ex-girlfriend. Repeat forward. This is why COVID long haulers flush like crazy with even 50 mg doses of niacin.
Note:
• Type I interferons (IFNs) derived from plasmacytoid dendritic cells (PDCs) are critical for antiviral responses
• Pyruvic acid or pyruvate is a key intermediate in the glycolytic and pyruvate dehydrogenase pathways, which are involved in biological energy production.
• Acetyl-CoA is a molecule that participates in many biochemical reactions in protein, carbohydrate and lipid metabolism.
As the virus leaves each cell, it and all the crazy inflammation it amplified [hypered], leaves melatonin depleted and stunts further the PDC from pyruvate to acetylCoA. This is needed for AAANAT receptor from tryptophan to serotonin to melatonin stunted too, and so melatonin isn't made more and more.
Note:
The key regulatory step in melatonin synthesis is catalyzed by arylalkylamine N-acetyltransferase (AANAT), which converts serotonin to N-acetylserotonin.
This leaves ACE2 downregulated, and happens especially in the intestines/colon.
This is how the virus/spikes - like IVM gains easy access to your brain/nervous system then - your gut becomes leaky with this ravaging of melatonin and inflammation. This gives easy access through the Vagus nerve to cross into BBB (blood brain barrier) and nervous systems where the most bang for the buck energy is for them.
Basically the virus/spikes have to deplete your already deficient melatonin and niacin to succeed and be thermodynamically attracted in the first place.
So keeping NIATONIN sufficient/repleting it takes back control of YOUR energy metabolism that the spikes try to take over for their food (energy).
It (NIATONIN) doesn't just push out inflammation. It allows T-cell differentiation (melatonin through ACE2 aka GPR109A expression). Then niacin comes in which is literally an innate/mandatory function of the recruitment and facilitation of T-cells, killer cells, and B cells. It induces phagocytosis, denatures, kills, and clears the virus as well as all pathogens and all toxins. It's a feasting grounds for them.
Note:
GPR109A (encoded by Niacr1) is a receptor for butyrate in the colon. GPR109A is also a receptor for niacin, which is also produced by gut microbiota and suppresses intestinal inflammation.
https://pubmed.ncbi.nlm.nih.gov/24412617/
NIACIN: https://purebulk.com/products/niacin-vitamin-b3-immediate-release?sca_ref=1004090.8JspdBHd04…
MELATONIN: https://purebulk.com/products/melatonin?sca_ref=1004090.8JspdBHd04…
Precision (0.000 g) Scale: https://purebulk.com/products/gemini-20-digital-scale?sca_ref=1004090.8JspdBHd04…
This graphic contains the protocol. Please read it all, especially the top portion where is says to eliminate certain things while using the protocol.
To follow up: The 10X Health folks look at the five genes at the center of energy production in the human cell. I had 50% mutations in four of the five, that is to say, I inherited one good gene and one “defective” gene from my parents. In principle that means that I would only produce 50% of the amino acids that those genes normally produce. They recommended that I take L-methionine and trimethylglycine (remember those) to augment what my cells were producing, plus D3 and magnesium glycinate.
My blood tests came out fantastic, including a total cholesterol of 175, with HDL 70 (> 39 is good), LDL 92 (< 99 is good), and cholesterol ratio 2.5 (< 3.5 is good). The niacin is doing its job.
I asked Dmitry about the genes. He said the “problematic” genes were involved in alternate energy pathways, which only come into play if niacin is deficient. He didn’t think I needed to do anything about them as long as I kept up with the niacin (and L-glutamine).
Another Dmitry update: He’s still sticking with niacin and glutamine as the niacin protocol, but this week he switched to a different form of glutamine. It’s N-acetyl L-glutamine. This form is more chemically stable so it survives mixing and digestion better, but provides the same stuff to the cell.
PureBulk.com is still the preferred vendor.
My understanding of the importance of glutamine is this: when doing its magic, each niacin molecule combines with a glutamine molecule. Glutamine is pretty common in the cellular soup (or should be), but taking glutamine along with the niacin makes sure that the existing glutamine doesn’t get used up.
Glutamine supplementation is a known cancer preventive because it makes the non-cancer cells work more effectively.
The “final” niacin protocol is now available in combined capsule form from PureBulk:
https://purebulk.com/products/GPR109A?sca_ref=1004090.8JspdBHd04
It contains niacin, n-acetyl l-glutamine, and folic acid. People are reporting good results from it, including a moderated flush. I think that link will automatically provide the 10% DMITRYKATS discount.
Each capsule provides 250 mg of niacin, so do the math to figure out how many capsules to take for your chosen dose of niacin.
... and Dmitry wonders why his niacin recommendations haven't gone viral. I applaud him on his continued efforts to get the niacin protocol just right. But it's hard to explain to niacin normies why it keeps changing.
In case you want to try it, the new protocol is 1.25 g of niacin to one 25 mg (of iron) capsule of the Swanson ferric citrate. That is the correct proportion. You can adjust them up or down as you prefer as long as you keep the ratio.
Two reasons.
1. He's a dick and is mean online.
B. He keeps changing the formula and it's difficult to keep up.
Is this what we’re looking for?
Swanson Iron Citrate 25 Milligrams
https://www.amazon.com/Swanson-Iron-Citrate-Milligrams-Capsules/dp/B073VM1YXN/ref=sr_1_1?keywords=Swanson+ferric+citrate&sr=8-1
On Amazon Swanson Iron Citrate is $8.74.
On the Swanson site it’s $2.86
I got 2 bottles from Swanson with shipping and tax for $12.13.
Yes.
In his endless quest for the truth, Dmitry has made another switch in the protocol, now adding iron in the form of ferric citrate specifically. He has concluded that niacin + iron eliminates the need for glutamine and folic acid. With iron the amount of glutamine normally circulating in the body is sufficient, and with iron the gut bacteria will naturally produce sufficient folic acid.
In my opinion, you might as well use up the GPR109A you have, supplementing it with ferric citrate (Swanson’s is the best and remarkably cheap). When you’ve used it up you can switch to PureBulk niacin (less than $10/bottle) along with the iron.
Business-wise, Dmitry has shot himself in the foot, because he was getting modest royalties from the GPR109A product. As you know, he has a history of doing that, by continually modifying the protocol to get it right.
I believe that the niacin has been providing me benefits from the get-go, three years ago. Although I’ve bought and thrown away a lot of different supplements as I’ve followed his experiments, it’s been worth it.
Y’all gotta see this.
MY SOLUTION for THE POISON - SOONER THAN EXPECTED!
Myself, David Nixon, and others wish to reveal the very thing i discovered recently. It has shown incredible results via visual urine analysis and by recovery.
https://managainstthemicrobes.substack.com/p/my-solution-sooner-than-expected
In a nutshell these guys stumbled upon SODIUM CITRATE doing some weird stuff to their microscope slides. They were using the sodium citrate to help with clarity in blood slides. What they found is it killed all the spirochetes on the slide (used too much).
So Karl C decided to drink some. Although he drank more than would be used in food products (see niacin) he noticed remarkable results. He said he felt relieved (of what I do not know) almost immediately. He captured and analyzed his urine after drinking the sodium citrate. After it settled he was amazed.
I think this guy might be on to something.
The sodium citrate experiment is pretty cool. Google shows lots of existing research on the use of sodium citrate to boost the performance of long-distance athletes. It also chelates calcium out of the circulatory system, so I wonder if the white stuff that settles out of the guy’s urine is just calcium.
I suppose it’s just a coincidence that Dmitry settled on ferric citrate to complement niacin. Scratch that! In recent weeks he’s moved on to ferric ammonium citrate instead of ferric citrate. The amount of (ferric ammonium) citrate that Dmitry recommends is in the tens of milligrams, not the multigram doses discussed above, and I think it’s the ferric, not the citrate, that Dmitry considers important.
Is Dimitri looking for covid prevention, long covid and vax cure all in one?
Sorry, just noticed your question.
Dmitry claims that niacin prevents COVID, cures COVID, remediates long COVID, and heals vaccine injuries. He also thinks regular niacin will permit you to live as long as people did in the Old Testament.
YMMV.
What’s your experience with cayenne?
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