Posted on 09/09/2021 6:58:17 AM PDT by numberonepal
Niacin and Melatonin work in synergy. The melatonin opens the gateway to cells and the inflammation within the cells. Niacin gets inside and kicks the crap out of it. We are all depleted of melatonin, so everyone's doses are different.
The Sweet Spot is when there is No Flush. Not even a tingle occurs. Hence, all the melatonin is being used up as well as the niacin to remove inflammation and restore the cells to homeostasis. The Flush is when excess niacin is not being used by the melatonin and goes to the skin capillaries.
The environmental stresses of modern life can lead to shortages of nutrients, especially melatonin and niacin, leading to the accumulation of free radicals and inflammation. The virus was targeted to affect the ACE2 receptors, which are regulated by melatonin and niacin. Once in your cells the virus consumes your energy, depletes melatonin, down-regulates the ACE2 receptors (especially in the intestines producing a leaky gut) giving the virus and spikes easy access to your brain and nervous system through the Vagus nerve.
The virus thrives in a melatonin/niacin deficient environment. The virus uses the energy from inflammation for its fitness (fuel). Supplementing melatonin and niacin reduces the inflammation that makes your body more vulnerable and reactivates your immune system to take care of the virus.
Over the course of life the lack of nutrients, especially melatonin and niacin, can't counter the progression of bad health behaviors throughout that life. New exposures like electronics, geothermal shifts, etc, a stressful life and poorer quality food these days all compound these deficiencies. Our continued dynamic deficiency in especially NIATONIN (niacin/melatonin) leads to the accumulation of more energy not expended out as per in. Because of this free radical electrons form and inflammation accumulates.
It's literally like the virus and covid pathogenesis, just slower.
These viruses or their gain of function research - whatever you want to imagine it is - have evolved since SARS-1 in 2000 to target these energy receptors; aka ACE2; what niacin and melatonin regulate.
It's a feasting ground for them (viruses).
Note:
Niacin and melatonin regulate ACE2 (Angiotensin-converting enzyme 2).
ACE2 is an enzyme attached to the membrane of cells located in the intestines, kidney, testis, gallbladder, and heart. ACE2 lowers blood pressure by catalyzing the hydrolysis of angiotensin II into angiotensin.
They're (viruses) thermodynamically attracted to people who have more inflammation for them to use for their fitness (fuel). These high expressed ACE2 (aka niacin receptors) along with the SR-B1 coreceptor right next to it - they (virus) sneak in this.
Note:
SR-B1 is a scavenger receptor class B type 1. It functions as a receptor for high-density lipoprotein. It is also know as CD36, a scavenger receptor class B member 3.
SR-BI/CD36 chimeric receptors define extracellular subdomains of SR-BI critical for cholesterol transport
https://pubmed.ncbi.nlm.nih.gov/25211142/
The SR-B1 is where HDL dumps off cholesterol from blood into tissue to prevent atherosclerosis. Because the cholesterol was leaking out of the tissue after it reached threshold, it can not contain it anymore due to too much pressure. As a result, HDL lowers because it's not getting developed in the liver anymore. The HDL has to attend to scooping more cholesterol back into tissue, and is used up real quick.
The virus then gets in cells and as it literally continues to consume your energy until it reaches a threshold it needs of energy to double (replicate). As it does this it depletes melatonin. It also makes it a lot easier if you have deficient melatonin. You can see now why unhealthy and older people who have not had enough melatonin and niacin as most at risk. They also have low HDL/high TG (triglycerides). The depleted melatonin makes the PDC receptor, already stunted from accumulated inflammation over a lifetime, from pyruvate to Acetyl-CoA even more stunted. Due to this melatonin gets gradually even more depleted into say long haul COVID. As soon as the virus meets threshold to replicate it moves out the mitochondria, and on to the next one (cell) like a bad ex-girlfriend. Repeat forward. This is why COVID long haulers flush like crazy with even 50 mg doses of niacin.
Note:
• Type I interferons (IFNs) derived from plasmacytoid dendritic cells (PDCs) are critical for antiviral responses
• Pyruvic acid or pyruvate is a key intermediate in the glycolytic and pyruvate dehydrogenase pathways, which are involved in biological energy production.
• Acetyl-CoA is a molecule that participates in many biochemical reactions in protein, carbohydrate and lipid metabolism.
As the virus leaves each cell, it and all the crazy inflammation it amplified [hypered], leaves melatonin depleted and stunts further the PDC from pyruvate to acetylCoA. This is needed for AAANAT receptor from tryptophan to serotonin to melatonin stunted too, and so melatonin isn't made more and more.
Note:
The key regulatory step in melatonin synthesis is catalyzed by arylalkylamine N-acetyltransferase (AANAT), which converts serotonin to N-acetylserotonin.
This leaves ACE2 downregulated, and happens especially in the intestines/colon.
This is how the virus/spikes - like IVM gains easy access to your brain/nervous system then - your gut becomes leaky with this ravaging of melatonin and inflammation. This gives easy access through the Vagus nerve to cross into BBB (blood brain barrier) and nervous systems where the most bang for the buck energy is for them.
Basically the virus/spikes have to deplete your already deficient melatonin and niacin to succeed and be thermodynamically attracted in the first place.
So keeping NIATONIN sufficient/repleting it takes back control of YOUR energy metabolism that the spikes try to take over for their food (energy).
It (NIATONIN) doesn't just push out inflammation. It allows T-cell differentiation (melatonin through ACE2 aka GPR109A expression). Then niacin comes in which is literally an innate/mandatory function of the recruitment and facilitation of T-cells, killer cells, and B cells. It induces phagocytosis, denatures, kills, and clears the virus as well as all pathogens and all toxins. It's a feasting grounds for them.
Note:
GPR109A (encoded by Niacr1) is a receptor for butyrate in the colon. GPR109A is also a receptor for niacin, which is also produced by gut microbiota and suppresses intestinal inflammation.
https://pubmed.ncbi.nlm.nih.gov/24412617/
NIACIN: https://purebulk.com/products/niacin-vitamin-b3-immediate-release?sca_ref=1004090.8JspdBHd04…
MELATONIN: https://purebulk.com/products/melatonin?sca_ref=1004090.8JspdBHd04…
Precision (0.000 g) Scale: https://purebulk.com/products/gemini-20-digital-scale?sca_ref=1004090.8JspdBHd04…
This graphic contains the protocol. Please read it all, especially the top portion where is says to eliminate certain things while using the protocol.
Great to hear. I seem to have lost some of the benefits from the high doses, but still way better than before I started. After the New Year I’mma try the curcumin method and see what happens.
My gut instinct (no pun intended?) is to stick with 1200-1500mg doses of niacin, regardless of how much or little curcumin. It has been remodeling my body - in a good way. I’m 67, and eat healthy and exercise and all that, but was beginning to resign myself to my more slightly dumpy-ish shape because, well, I’m 67. But lately I’ve noticed that my pants were fitting loosely, and lo and behold, I’m fitting into some of the clothes that I wore 15 years ago that had gotten uncomfortably or even impossibly tight. Muscle is easier to build, too. And I haven’t changed my diet or exercise routines, but they just seem to be having actual more noticeable results for me now. Niacin is the only thing that’s been added... hmmm!
#1, this would be a good time to thank you (and Dmitri Kats) for introducing niacin into my life, for creating the NiaCur (née Niatonin) thread, and for passing along information from the torrential Telegram stream.
Thank you.
Thanks also to the rest of you experimental subjects for helping to birth this new health regimen.
My pleasure.
Dang, I’m having conniptions about pulling the trigger on bulk curcumin while the PureBulk sale is on for almost another 24 hours. 15% discount, better than the 10% dmitrykats one.
I’m worried that he will change the protocol again and I’ll be stuck holding the bag again (*cough* Melatonin *cough*). LOL What to do, what to do? Ha!
Hold tight for now. He's working with adding glutamine presently.
Oh noes, not NiaGlut now?
I really feel sorry for people who buy thousands of dollars worth of things that he ends up scrapping from the protocol!
I don’t think anyone has spent “thousands”. I’ve financed 5 people and have not spent one thousand yet. But some people do buy all the co-factors as well. All the protocols have worked for the vast majority. The principle remains - get niacin into the cells to drive out inflammation. He’s trying to get it right for everyone, and I think he’s disappointed in the long Covid results. Perfection is the enemy.
Well, last night PureBulk had loads of curcimin available in all size bags, and now it’s sold out. You snooze you lose, I guess. And that stuff is expensive! So it looks like some folks must be spending the big bucks. And now I see Dmitri is frowning on NOW brand capsules, which he originally endorsed, because of quality issues. Sigh.
The MOST POWERFUL Antioxidant is Melatonin, NOT Glutathione
https://www.youtube.com/watch?v=sNklS0lzlgA
Bookmark melatonin antioxidant
One of the interesting changes I’ve noted with niacin is a marked decrease in body odor, specifically armpit odor. Deodorant used to be a necessity, but even with deodorant I needed to shower daily, hoping that the deodorant would last through the day. Now the need for deodorant is much less and I can go two or three days without a shower.
I think it’s had a significant effect on my breath odor as well.
Very Interesting
There’s an another aspect to my perspiration odor. I’ve been doing hot yoga for nearly two decades. Most of that was Bikram hot yoga, which is done in a combination of high heat and high humidity, so the sweat would drip off like crazy. For me, at least, this wasn’t normal sweat, but a very pungent sweat, meaning I had to wash my clothes and yoga towel immediately on returning home or Mrs. AZLiberty would throw me out of the house.
Surely this smelly sweat meant I was getting rid of lots of toxins, so it had to be good for me.
Now when I get back from hot yoga, like one of the lovely Texas-based virtual instructors says, “It ain’t no thing.” Sometimes I don’t even bother changing out of my yoga clothes for quite a while, and Mrs. AZLiberty hasn’t complained.
It seems that niacin has changed my entire biochemistry, so that my body doesn’t even generate the “toxins” that I used to get rid of through hot yoga.
The super high dosing was a big time detox. I’ve experienced similar things.
My current curcumin+niacin regimen, and how I got here (next message):
I previously reported the benefits I have received from being on curcumin+niacin (”NiaCur”). Here are some details:
Currently, I take curcumin once a day, either before or with breakfast. I take two 665 mg capsules of “Turmeric Curcumin”, the NOW brand.
https://www.amazon.com/NOW-Supplements-Curcumin-Turmeric-Capsules/dp/B000QSLHIU
I take 1.5 to 2 grams of niacin at a time (from Pure Bulk). The first dose is 20-30 min after the morning curcumin (and food). The second dose is in the evening (early or late doesn’t seem to matter). I generally dissolve the niacin in 24 oz of liquid. It takes warm liquid to dissolve the niacin, so I measure the niacin (1/2 tsp = 2 grams) into the cup, add an ounce of wolfberry purée (another habit of mine), add a cup of room-temperature filtered water, add approx. 10 oz of boiling water to dissolve the niacin, stir until dissolved, and then add a few ounces of cranberry cocktail to sweeten it up a little and cool it to an easy drinking temperature. Plain niacin has a nondescript acidic flavor, which gets boring.
https://purebulk.com/products/niacin-vitamin-b3-immediate-release
Seriacin - Niacin and L-Serine
Click for bigger.
My history on Niatonin/Niacur (you can find more details upthread):
I started with the melatonin+niacin approach months ago. This involved gradually increasing the niacin while attempting to prevent the flush with melatonin. My first experience was a hot mess, with a full-on flush and my blood pressure dropping below 80. I soon learned that you’re not supposed to do this on an empty stomach. It got better, although I was eventually consuming massive amounts of melatonin (hundreds of milligrams vs. the usual go-to-sleep dose of 3 mg). It didn’t make me as sleepy as I thought I might, but it wasn’t optimal.
The next approach was using pistachios and later dried tart cherries as the melatonin source. Fortunately, I like pistachios and I was glad to learn about the dried cherries. These worked well until I then switched to sodium butyrate as suggested by Dr. K, which worked even better, and then to curcumin, which works very well indeed.
I think it was in the butyrate phase that I raised my niacin dose to as high as 3 grams, at which point my body went through its biggest change. I had 24 hours of complete though unplanned cleanse and experienced an immediate and continuing weight loss of several pounds. The high dose of niacin cleared something out of my gut that has yet to return.
In switching from butyrate to curcumin, I think I overlapped them for a couple of days and then went straight to curcumin. I meant to keep a daily journal — and did for a month or so — but then just got too busy with other things.
Once I switched to curcumin, I quit measuring the niacin with a scale, and started using volume measure. It turns out 2 g is just about exactly 1/2 tsp, so I just measure out a half a teaspoon, sometimes a little less, sometimes a little more.
My recommendation: try an initial dose of niacin, 500 mg or less, and gradually work up to 1 or 2 g. If you’re still OK at 2 g, try 3 for a while to see if there’s additional benefits. You might as well start the curcumin at two capsules — it’s harmless and good for you.
Seriacin? Seriously?
This is going to be another confusing iPhone trigger. Whenever Mrs. AZLiberty says “Seriously”, her iPhone talks back to her, thinking she’s talking with Siri, the voice assistant. I don’t think I’ll mention Seriacin to her.
Are you ready for another version?
I’m through with all the changes. Niacin it is for me, nothing more. And actually, I was thinking of taking a break from it for a week or two, and only taking my “previously normal” array of supplements, just to see what happens.
I got my L-serine today. I’ll try the starting dose of TWELVE GRAMS on Sunday.
I’m just a wild and crazy guy.
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