Posted on 09/09/2021 6:58:17 AM PDT by numberonepal
Niacin and Melatonin work in synergy. The melatonin opens the gateway to cells and the inflammation within the cells. Niacin gets inside and kicks the crap out of it. We are all depleted of melatonin, so everyone's doses are different.
The Sweet Spot is when there is No Flush. Not even a tingle occurs. Hence, all the melatonin is being used up as well as the niacin to remove inflammation and restore the cells to homeostasis. The Flush is when excess niacin is not being used by the melatonin and goes to the skin capillaries.
The environmental stresses of modern life can lead to shortages of nutrients, especially melatonin and niacin, leading to the accumulation of free radicals and inflammation. The virus was targeted to affect the ACE2 receptors, which are regulated by melatonin and niacin. Once in your cells the virus consumes your energy, depletes melatonin, down-regulates the ACE2 receptors (especially in the intestines producing a leaky gut) giving the virus and spikes easy access to your brain and nervous system through the Vagus nerve.
The virus thrives in a melatonin/niacin deficient environment. The virus uses the energy from inflammation for its fitness (fuel). Supplementing melatonin and niacin reduces the inflammation that makes your body more vulnerable and reactivates your immune system to take care of the virus.
Over the course of life the lack of nutrients, especially melatonin and niacin, can't counter the progression of bad health behaviors throughout that life. New exposures like electronics, geothermal shifts, etc, a stressful life and poorer quality food these days all compound these deficiencies. Our continued dynamic deficiency in especially NIATONIN (niacin/melatonin) leads to the accumulation of more energy not expended out as per in. Because of this free radical electrons form and inflammation accumulates.
It's literally like the virus and covid pathogenesis, just slower.
These viruses or their gain of function research - whatever you want to imagine it is - have evolved since SARS-1 in 2000 to target these energy receptors; aka ACE2; what niacin and melatonin regulate.
It's a feasting ground for them (viruses).
Note:
Niacin and melatonin regulate ACE2 (Angiotensin-converting enzyme 2).
ACE2 is an enzyme attached to the membrane of cells located in the intestines, kidney, testis, gallbladder, and heart. ACE2 lowers blood pressure by catalyzing the hydrolysis of angiotensin II into angiotensin.
They're (viruses) thermodynamically attracted to people who have more inflammation for them to use for their fitness (fuel). These high expressed ACE2 (aka niacin receptors) along with the SR-B1 coreceptor right next to it - they (virus) sneak in this.
Note:
SR-B1 is a scavenger receptor class B type 1. It functions as a receptor for high-density lipoprotein. It is also know as CD36, a scavenger receptor class B member 3.
SR-BI/CD36 chimeric receptors define extracellular subdomains of SR-BI critical for cholesterol transport
https://pubmed.ncbi.nlm.nih.gov/25211142/
The SR-B1 is where HDL dumps off cholesterol from blood into tissue to prevent atherosclerosis. Because the cholesterol was leaking out of the tissue after it reached threshold, it can not contain it anymore due to too much pressure. As a result, HDL lowers because it's not getting developed in the liver anymore. The HDL has to attend to scooping more cholesterol back into tissue, and is used up real quick.
The virus then gets in cells and as it literally continues to consume your energy until it reaches a threshold it needs of energy to double (replicate). As it does this it depletes melatonin. It also makes it a lot easier if you have deficient melatonin. You can see now why unhealthy and older people who have not had enough melatonin and niacin as most at risk. They also have low HDL/high TG (triglycerides). The depleted melatonin makes the PDC receptor, already stunted from accumulated inflammation over a lifetime, from pyruvate to Acetyl-CoA even more stunted. Due to this melatonin gets gradually even more depleted into say long haul COVID. As soon as the virus meets threshold to replicate it moves out the mitochondria, and on to the next one (cell) like a bad ex-girlfriend. Repeat forward. This is why COVID long haulers flush like crazy with even 50 mg doses of niacin.
Note:
• Type I interferons (IFNs) derived from plasmacytoid dendritic cells (PDCs) are critical for antiviral responses
• Pyruvic acid or pyruvate is a key intermediate in the glycolytic and pyruvate dehydrogenase pathways, which are involved in biological energy production.
• Acetyl-CoA is a molecule that participates in many biochemical reactions in protein, carbohydrate and lipid metabolism.
As the virus leaves each cell, it and all the crazy inflammation it amplified [hypered], leaves melatonin depleted and stunts further the PDC from pyruvate to acetylCoA. This is needed for AAANAT receptor from tryptophan to serotonin to melatonin stunted too, and so melatonin isn't made more and more.
Note:
The key regulatory step in melatonin synthesis is catalyzed by arylalkylamine N-acetyltransferase (AANAT), which converts serotonin to N-acetylserotonin.
This leaves ACE2 downregulated, and happens especially in the intestines/colon.
This is how the virus/spikes - like IVM gains easy access to your brain/nervous system then - your gut becomes leaky with this ravaging of melatonin and inflammation. This gives easy access through the Vagus nerve to cross into BBB (blood brain barrier) and nervous systems where the most bang for the buck energy is for them.
Basically the virus/spikes have to deplete your already deficient melatonin and niacin to succeed and be thermodynamically attracted in the first place.
So keeping NIATONIN sufficient/repleting it takes back control of YOUR energy metabolism that the spikes try to take over for their food (energy).
It (NIATONIN) doesn't just push out inflammation. It allows T-cell differentiation (melatonin through ACE2 aka GPR109A expression). Then niacin comes in which is literally an innate/mandatory function of the recruitment and facilitation of T-cells, killer cells, and B cells. It induces phagocytosis, denatures, kills, and clears the virus as well as all pathogens and all toxins. It's a feasting grounds for them.
Note:
GPR109A (encoded by Niacr1) is a receptor for butyrate in the colon. GPR109A is also a receptor for niacin, which is also produced by gut microbiota and suppresses intestinal inflammation.
https://pubmed.ncbi.nlm.nih.gov/24412617/
NIACIN: https://purebulk.com/products/niacin-vitamin-b3-immediate-release?sca_ref=1004090.8JspdBHd04…
MELATONIN: https://purebulk.com/products/melatonin?sca_ref=1004090.8JspdBHd04…
Precision (0.000 g) Scale: https://purebulk.com/products/gemini-20-digital-scale?sca_ref=1004090.8JspdBHd04…
This graphic contains the protocol. Please read it all, especially the top portion where is says to eliminate certain things while using the protocol.
There’s some kind of dust up going on there now. I’m not getting in to it, but it looks as if Kats has lost it and turned on his biggest supporters.
Thanks for the update.
Wow, I was thinking about building a Rife machine. I can’t beat that price, no way. I might check it out. Thank you AZ.
PLEASE EVERYONE.- DO NOT DO RX WITH THIS UPCOMING FINAL PROTOCOL, WHICH WILL BE: SIMPLY NIACIN AND PIPERINE
Dr Kats explains the mechanics & rational of the Piperine/Niacin protocol and walks us through his thought process. After listening, I have no doubt we are at the root. As he said, “better to get here quicker than later or never.” I have uploaded it so we can study it - and he can have a transcript. Listen in any order. We will learn more as we all experience this together. There will be a lot to unpack and learn as the early adopters give it a go.
1 Dr Kats on Piperine & Niacin
https://otter.ai/u/-EsMqhEpqrrES7HUCYVyJEtakGA
2 Dr Kats on Piperine & Niacin
https://otter.ai/u/JBP5VCigrWH4uZg-UYvyLqcDmX0)
3 Dr Kats on Piperine & Niacin (shorter)
https://otter.ai/u/o7hDCSbwKwAbHwD-jk2w0ew0ngg
4 Dr Kats on Piperine & Niacin (Shorter)
https://otter.ai/u/OqH62DJGBk18y3GaOm_Scy1bj4Y
Good gawd those latest audio files are a mess from Kats. Why can’t he write this stuff down and at least have an outline? Horrible.
Kats is so confident in the new curcumin protocol that he’s changed the name to NiaCur. A definite improvement.
Anybody doing curcumin yet? Mine arrives on Wednesday.
I’m going to do it, but after the New Year. I’ll watch the thread and see what happens.
A Houston friend of my brother, originally from Venezuela, has tested positive for COVID. He found a Spanish-speaking doctor online that recommends the Niatonin cure.
My brother beat me to the curcumin version of Niatonin. He wasn’t pleased with his first attempt: his body glowed like Rudolph’s nose.
I’m heating the same. First doses are kinda flushy, but it wanes.
Hearing, not heating. These damn bandages on my fingers. I tried to cut off my fingers with a circular saw and failed. Now they’re just a mangled hamburger mess. I’m soaking in silver water to clean and niacin water afterward (eeyouch!) to see if it promotes healing. I’m documenting in pictures each time I change bandages. Never let a crisis go to waste.
Ouch!
You might have better luck with a band saw. That's how my shop teacher got rid of his thumb.
Oh, how awful, #1 - hope the mangled digits heal quickly! And I stuck a finger in the way of my closing truck door a little over a week ago. Just pinched it, though, and left a bruise on my fingernail. Was getting all my gear out to play at the church service. I was lucky - it just felt like it was flashing on and off for a bit. Ironically, I had slammed the same finger in my car door much worse than that about 30 years ago, and still have a scar from it!
RE: NiaCur - When I saw the name change (I’m only around 5-6000 posts behind on that Telegram thread), I didn’t immediately make the connection, and thought it was short for NiaCure, just to keep Dmitry from having to change it every time the protocol changed, since Niacin seemed to be the one constant. I still think it sounds like a dog, though. LOL
However, I was immediately intrigued by the thought of curcumin, since I’ve had nothing but positive experiences with supplements derived from spices and herbs. So yes, I’ve started it. What I don’t like is the price, however - and the fact that he’s recommending twice as much curcumin as niacin! Over 200 smackers for a kilo, could be a very pricy habit! I just bought a bottle of NOW capsules to try it out. On Day 3 now, and so far it hasn’t made me either gassy or runny. LOL
Cool. You’re a trooper. What are your doses?
I would say completely random, so far. 3 times a day, starting on a stomach that’s empty except for a drink of lemon/orange juice mixed with several powdered herbs I take. I’ve never actually taken more curcumin than niacin. I don’t want to use it up in a hurry! Curcumin is 665mg per capsule and most I’ve taken is 2 at a time, sometimes just 1. I’ve either kept the niacin at 1200-1500, or lowered it to match the curcumin, which I don’t like to do either, as I feel that’s depriving me of the niacin I was taking before, which has been giving me noticeable benefits. And now I’m reading a few people who say the powdered bulk curcumin is super messy to deal with, so capsules may be better. Others complain about the additives in the capsules. So I don’t know where I’ll ultimately be going with this, at the moment...
After a couple of days combining curcumin and butyrate (NiaButCur?), I did my first butyrate-free NiaCur dose today: two capsules of NOW curcumin followed by 2000 mg of niacin.
No flush!
Wow.
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