Posted on 09/09/2021 6:58:17 AM PDT by numberonepal
Niacin and Melatonin work in synergy. The melatonin opens the gateway to cells and the inflammation within the cells. Niacin gets inside and kicks the crap out of it. We are all depleted of melatonin, so everyone's doses are different.
The Sweet Spot is when there is No Flush. Not even a tingle occurs. Hence, all the melatonin is being used up as well as the niacin to remove inflammation and restore the cells to homeostasis. The Flush is when excess niacin is not being used by the melatonin and goes to the skin capillaries.
The environmental stresses of modern life can lead to shortages of nutrients, especially melatonin and niacin, leading to the accumulation of free radicals and inflammation. The virus was targeted to affect the ACE2 receptors, which are regulated by melatonin and niacin. Once in your cells the virus consumes your energy, depletes melatonin, down-regulates the ACE2 receptors (especially in the intestines producing a leaky gut) giving the virus and spikes easy access to your brain and nervous system through the Vagus nerve.
The virus thrives in a melatonin/niacin deficient environment. The virus uses the energy from inflammation for its fitness (fuel). Supplementing melatonin and niacin reduces the inflammation that makes your body more vulnerable and reactivates your immune system to take care of the virus.
Over the course of life the lack of nutrients, especially melatonin and niacin, can't counter the progression of bad health behaviors throughout that life. New exposures like electronics, geothermal shifts, etc, a stressful life and poorer quality food these days all compound these deficiencies. Our continued dynamic deficiency in especially NIATONIN (niacin/melatonin) leads to the accumulation of more energy not expended out as per in. Because of this free radical electrons form and inflammation accumulates.
It's literally like the virus and covid pathogenesis, just slower.
These viruses or their gain of function research - whatever you want to imagine it is - have evolved since SARS-1 in 2000 to target these energy receptors; aka ACE2; what niacin and melatonin regulate.
It's a feasting ground for them (viruses).
Note:
Niacin and melatonin regulate ACE2 (Angiotensin-converting enzyme 2).
ACE2 is an enzyme attached to the membrane of cells located in the intestines, kidney, testis, gallbladder, and heart. ACE2 lowers blood pressure by catalyzing the hydrolysis of angiotensin II into angiotensin.
They're (viruses) thermodynamically attracted to people who have more inflammation for them to use for their fitness (fuel). These high expressed ACE2 (aka niacin receptors) along with the SR-B1 coreceptor right next to it - they (virus) sneak in this.
Note:
SR-B1 is a scavenger receptor class B type 1. It functions as a receptor for high-density lipoprotein. It is also know as CD36, a scavenger receptor class B member 3.
SR-BI/CD36 chimeric receptors define extracellular subdomains of SR-BI critical for cholesterol transport
https://pubmed.ncbi.nlm.nih.gov/25211142/
The SR-B1 is where HDL dumps off cholesterol from blood into tissue to prevent atherosclerosis. Because the cholesterol was leaking out of the tissue after it reached threshold, it can not contain it anymore due to too much pressure. As a result, HDL lowers because it's not getting developed in the liver anymore. The HDL has to attend to scooping more cholesterol back into tissue, and is used up real quick.
The virus then gets in cells and as it literally continues to consume your energy until it reaches a threshold it needs of energy to double (replicate). As it does this it depletes melatonin. It also makes it a lot easier if you have deficient melatonin. You can see now why unhealthy and older people who have not had enough melatonin and niacin as most at risk. They also have low HDL/high TG (triglycerides). The depleted melatonin makes the PDC receptor, already stunted from accumulated inflammation over a lifetime, from pyruvate to Acetyl-CoA even more stunted. Due to this melatonin gets gradually even more depleted into say long haul COVID. As soon as the virus meets threshold to replicate it moves out the mitochondria, and on to the next one (cell) like a bad ex-girlfriend. Repeat forward. This is why COVID long haulers flush like crazy with even 50 mg doses of niacin.
Note:
• Type I interferons (IFNs) derived from plasmacytoid dendritic cells (PDCs) are critical for antiviral responses
• Pyruvic acid or pyruvate is a key intermediate in the glycolytic and pyruvate dehydrogenase pathways, which are involved in biological energy production.
• Acetyl-CoA is a molecule that participates in many biochemical reactions in protein, carbohydrate and lipid metabolism.
As the virus leaves each cell, it and all the crazy inflammation it amplified [hypered], leaves melatonin depleted and stunts further the PDC from pyruvate to acetylCoA. This is needed for AAANAT receptor from tryptophan to serotonin to melatonin stunted too, and so melatonin isn't made more and more.
Note:
The key regulatory step in melatonin synthesis is catalyzed by arylalkylamine N-acetyltransferase (AANAT), which converts serotonin to N-acetylserotonin.
This leaves ACE2 downregulated, and happens especially in the intestines/colon.
This is how the virus/spikes - like IVM gains easy access to your brain/nervous system then - your gut becomes leaky with this ravaging of melatonin and inflammation. This gives easy access through the Vagus nerve to cross into BBB (blood brain barrier) and nervous systems where the most bang for the buck energy is for them.
Basically the virus/spikes have to deplete your already deficient melatonin and niacin to succeed and be thermodynamically attracted in the first place.
So keeping NIATONIN sufficient/repleting it takes back control of YOUR energy metabolism that the spikes try to take over for their food (energy).
It (NIATONIN) doesn't just push out inflammation. It allows T-cell differentiation (melatonin through ACE2 aka GPR109A expression). Then niacin comes in which is literally an innate/mandatory function of the recruitment and facilitation of T-cells, killer cells, and B cells. It induces phagocytosis, denatures, kills, and clears the virus as well as all pathogens and all toxins. It's a feasting grounds for them.
Note:
GPR109A (encoded by Niacr1) is a receptor for butyrate in the colon. GPR109A is also a receptor for niacin, which is also produced by gut microbiota and suppresses intestinal inflammation.
https://pubmed.ncbi.nlm.nih.gov/24412617/
NIACIN: https://purebulk.com/products/niacin-vitamin-b3-immediate-release?sca_ref=1004090.8JspdBHd04…
MELATONIN: https://purebulk.com/products/melatonin?sca_ref=1004090.8JspdBHd04…
Precision (0.000 g) Scale: https://purebulk.com/products/gemini-20-digital-scale?sca_ref=1004090.8JspdBHd04…
This graphic contains the protocol. Please read it all, especially the top portion where is says to eliminate certain things while using the protocol.
Welcome to Flush News Network, Mama Shawna! I see you survived your trial by fire. I hope things continue to improve for you.
I think you should get on the butyrate protocol. That’s too much melatonin. At 500N you should be taking 7.5mg mellie for the 66.7:1 ratio. Finding that sweet spot is difficult and you’re already heading for a low ratio. 500N is like a squirt gun putting out a house fire.
I’m not giving up my guitar until I absolutely HAVE TO. And 56 is WAY too young to be giving up!
No search on arthritis, yet. Got totally absorbed into the tinnitus thing. I’ve been on an anti-inflammatory diet for many years now, just to combat it, plus keep weight down. I have a very sedentary job so I watch what I eat, and have been doing various things over the years to keep it at bay. So far, it’s not too bad. Just don’t want it to get as bad as my Dad. My right index finger knuckle just before your fingernail is pretty swollen/bent. Luckily, it bends to the left so I can still hold a pick, or finger pick if I want, LOL! Not much pain, just swelling. Fretting hand is fine, so far, but I’ve felt some tinges now and then.
What instruments do you play? 17strings makes me think 2 guitars and a 5 string banjo.
Haha, nope, but you’re on the right track - my moniker refers to my favorite (multiple) instruments. Precisely which ones those are will remain part of my mysterious online aura. ;) I actually have a whole slew of instruments, though, both plucked and bowed, although the bowed ones have been my bread and butter, so to speak.
Just decided to get daring, and dumped 2000mg of Niacin into my fruit smoothie, instead of the usual 1000. That’s double the most I’ve ever taken at a time! Been 1/2 hour, and I don’t feel any flush or tingle...
HAHA! Either way, I’d love to jam with you. If I ever make it to Florida I’ll have to look you up! Got two brothers and my Dad who live there, so it’s not impossible.
Wild and crazy, you are. After peaking at N3K and returning to N1K as a maintenance level (with butyrate), I no longer seem to need melatonin. I now only get a modest warm feeling with niacin alone, in 24 oz of water. I'm now starting to creep back up, but only 100mg at a time. Now at 0M/1200N.
I haven’t taken melatonin orally for several weeks, only through the skin. Just took 1500mg of N in water after supper. Haven’t taken any butyrate, ever. The bottle my husband ordered arrived today. I’d go sniff it, but he hasn’t opened it yet. ;-)
By the way, after my smoothie today, I worked out more intensely than I normally do. I set aside the usual 10 lb. dumbbells, and upped ‘em directly to 17 pounders (CWIDT?) to see if I could do the same numbers of arm exercise repetitions that I usually do. And I did! Actually, I’ve been trying to see if I can do enough weight training to make me sore the next day, but on that I have yet to succeed, even though I’m (slowly) increasing muscle mass. Let’s see how I feel tomorrow! Meanwhile, look out, MTG! 🏋🏽♀️ (lol, yeah right!)
Marking to circle back
TWO THOUSAND! Now you’re fighting fire!
Great news. You’ll be doing those MTG overhand pull ups in no time.
Updated #NIATONIN Protocol for Vax Injury, COVID and Long COVID recovery.
2x daily for adults (mainly for recovery; butyrate will not need to remain this high) - DO THIS AFTER MEALS (lunch & dinner):
800-1600 mg Taurine
+
10-15 mg MELATONIN <— evaluate as per 66.7:1 ratio N:M.
(melatonin supplementation may not be needed here, and instead just at night before bed)
+
3.6-5.0 g BUTYRATE
^ NOTE that a 3.6 g dose corresponds to six (6) separate BodyBio or Butyrex capsules; lower doses can be taken in more mild cases. Remove one pill per day on the third day.
+
200 mcg Selenium (w/ 1st and/or 2nd dose).
Wait 15-45 min (evaluate when is best).
1-3 g NIACIN per comfort/need
Perhaps start at 500 mg if your first time & not an emergency situation (don’t fear flush; try working up to at least 1 g doses as comfortably as possible)
10-15 mg Melatonin before bed at night. Once you wake up, take 1-3 g niacin.
Very easy to row. Propagates almost like a weed. Get a few in pots from local nursery as starters
re plant in garden with space to expand. Harvesting..just cut off a fat spiky branch and trim off the spikes with a sharp knife ...make a cut along the length of the spiky side and discard a thin strip with the spikes.
Then you can extract the gel...or slice some outer skin and use it as an application..
For info
I’m back up to N2K now. No melatonin. Down to two butyrate capsules.
Also doing B complex, ALCAR, zinc, C, iodine.
I seem to have lost another 2 lbs — for a total of 7.
One more is a full stone! GO!
The stone or stone weight (abbreviation: st.) is an English and imperial unit of mass equal to 14 pounds (approximately 6.35 kg). -- Wikipedia
Ordered some GABA and L-theanine today. Ready for another experiment.
Woo hoo. I haven’t gone that route yet. I prolly should since I once took Ivermectin.
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