Posted on 09/09/2021 6:58:17 AM PDT by numberonepal
Niacin and Melatonin work in synergy. The melatonin opens the gateway to cells and the inflammation within the cells. Niacin gets inside and kicks the crap out of it. We are all depleted of melatonin, so everyone's doses are different.
The Sweet Spot is when there is No Flush. Not even a tingle occurs. Hence, all the melatonin is being used up as well as the niacin to remove inflammation and restore the cells to homeostasis. The Flush is when excess niacin is not being used by the melatonin and goes to the skin capillaries.
The environmental stresses of modern life can lead to shortages of nutrients, especially melatonin and niacin, leading to the accumulation of free radicals and inflammation. The virus was targeted to affect the ACE2 receptors, which are regulated by melatonin and niacin. Once in your cells the virus consumes your energy, depletes melatonin, down-regulates the ACE2 receptors (especially in the intestines producing a leaky gut) giving the virus and spikes easy access to your brain and nervous system through the Vagus nerve.
The virus thrives in a melatonin/niacin deficient environment. The virus uses the energy from inflammation for its fitness (fuel). Supplementing melatonin and niacin reduces the inflammation that makes your body more vulnerable and reactivates your immune system to take care of the virus.
Over the course of life the lack of nutrients, especially melatonin and niacin, can't counter the progression of bad health behaviors throughout that life. New exposures like electronics, geothermal shifts, etc, a stressful life and poorer quality food these days all compound these deficiencies. Our continued dynamic deficiency in especially NIATONIN (niacin/melatonin) leads to the accumulation of more energy not expended out as per in. Because of this free radical electrons form and inflammation accumulates.
It's literally like the virus and covid pathogenesis, just slower.
These viruses or their gain of function research - whatever you want to imagine it is - have evolved since SARS-1 in 2000 to target these energy receptors; aka ACE2; what niacin and melatonin regulate.
It's a feasting ground for them (viruses).
Note:
Niacin and melatonin regulate ACE2 (Angiotensin-converting enzyme 2).
ACE2 is an enzyme attached to the membrane of cells located in the intestines, kidney, testis, gallbladder, and heart. ACE2 lowers blood pressure by catalyzing the hydrolysis of angiotensin II into angiotensin.
They're (viruses) thermodynamically attracted to people who have more inflammation for them to use for their fitness (fuel). These high expressed ACE2 (aka niacin receptors) along with the SR-B1 coreceptor right next to it - they (virus) sneak in this.
Note:
SR-B1 is a scavenger receptor class B type 1. It functions as a receptor for high-density lipoprotein. It is also know as CD36, a scavenger receptor class B member 3.
SR-BI/CD36 chimeric receptors define extracellular subdomains of SR-BI critical for cholesterol transport
https://pubmed.ncbi.nlm.nih.gov/25211142/
The SR-B1 is where HDL dumps off cholesterol from blood into tissue to prevent atherosclerosis. Because the cholesterol was leaking out of the tissue after it reached threshold, it can not contain it anymore due to too much pressure. As a result, HDL lowers because it's not getting developed in the liver anymore. The HDL has to attend to scooping more cholesterol back into tissue, and is used up real quick.
The virus then gets in cells and as it literally continues to consume your energy until it reaches a threshold it needs of energy to double (replicate). As it does this it depletes melatonin. It also makes it a lot easier if you have deficient melatonin. You can see now why unhealthy and older people who have not had enough melatonin and niacin as most at risk. They also have low HDL/high TG (triglycerides). The depleted melatonin makes the PDC receptor, already stunted from accumulated inflammation over a lifetime, from pyruvate to Acetyl-CoA even more stunted. Due to this melatonin gets gradually even more depleted into say long haul COVID. As soon as the virus meets threshold to replicate it moves out the mitochondria, and on to the next one (cell) like a bad ex-girlfriend. Repeat forward. This is why COVID long haulers flush like crazy with even 50 mg doses of niacin.
Note:
• Type I interferons (IFNs) derived from plasmacytoid dendritic cells (PDCs) are critical for antiviral responses
• Pyruvic acid or pyruvate is a key intermediate in the glycolytic and pyruvate dehydrogenase pathways, which are involved in biological energy production.
• Acetyl-CoA is a molecule that participates in many biochemical reactions in protein, carbohydrate and lipid metabolism.
As the virus leaves each cell, it and all the crazy inflammation it amplified [hypered], leaves melatonin depleted and stunts further the PDC from pyruvate to acetylCoA. This is needed for AAANAT receptor from tryptophan to serotonin to melatonin stunted too, and so melatonin isn't made more and more.
Note:
The key regulatory step in melatonin synthesis is catalyzed by arylalkylamine N-acetyltransferase (AANAT), which converts serotonin to N-acetylserotonin.
This leaves ACE2 downregulated, and happens especially in the intestines/colon.
This is how the virus/spikes - like IVM gains easy access to your brain/nervous system then - your gut becomes leaky with this ravaging of melatonin and inflammation. This gives easy access through the Vagus nerve to cross into BBB (blood brain barrier) and nervous systems where the most bang for the buck energy is for them.
Basically the virus/spikes have to deplete your already deficient melatonin and niacin to succeed and be thermodynamically attracted in the first place.
So keeping NIATONIN sufficient/repleting it takes back control of YOUR energy metabolism that the spikes try to take over for their food (energy).
It (NIATONIN) doesn't just push out inflammation. It allows T-cell differentiation (melatonin through ACE2 aka GPR109A expression). Then niacin comes in which is literally an innate/mandatory function of the recruitment and facilitation of T-cells, killer cells, and B cells. It induces phagocytosis, denatures, kills, and clears the virus as well as all pathogens and all toxins. It's a feasting grounds for them.
Note:
GPR109A (encoded by Niacr1) is a receptor for butyrate in the colon. GPR109A is also a receptor for niacin, which is also produced by gut microbiota and suppresses intestinal inflammation.
https://pubmed.ncbi.nlm.nih.gov/24412617/
NIACIN: https://purebulk.com/products/niacin-vitamin-b3-immediate-release?sca_ref=1004090.8JspdBHd04…
MELATONIN: https://purebulk.com/products/melatonin?sca_ref=1004090.8JspdBHd04…
Precision (0.000 g) Scale: https://purebulk.com/products/gemini-20-digital-scale?sca_ref=1004090.8JspdBHd04…
This graphic contains the protocol. Please read it all, especially the top portion where is says to eliminate certain things while using the protocol.
60P/30min/2200N in 24 oz today. Teeny flush. Great feeling of happiness afterwards.
Since my candida clean-out last week, my senses have been significantly more acute. I smell and taste things more than before. I also seem to have overcome my chocolate addiction. I still enjoy it but I don’t “need” it.
The very latest Telegram posts seem to indicate that cherry is now off the menu. True?
We usually make our oatmeal cookies with craisins instead of raisins. This time I made some with dried tart cherries. Yum!!!
(I wonder what would happen if you add Tabasco sauce to the mix for a good solid endorphin rush!)
Imma try it with Tabasco and oysters.
LB puts down the latest instruction on #NIATONIN Protocol. pic.twitter.com/hvXjJx4Lnc— WeThePeeple (@WeThePeeple9) October 19, 2021
Oddly, it involved needles, too.
(I wonder what would happen if you add Tabasco sauce to the mix for a good solid endorphin rush!)
My brother did almost that the other day, except with three Chinese varieties of fresh hot peppers. He thought it might have prevented the flush feeling.
60P/30min/2500N/24oz this morning and 2600N this afternoon. No significant flush. I feel a little off this afternoon, but it may be because I’m not eating enough. My body barely gives me signals to eat anymore.
Kats done changed it again. He’s back to the butyrate, but this time in high doses and lower doses of mellie. I can’t keep up.
My body barely gives me signals to eat anymore.
———————————————————+
I’m not taking nearly as much as you are, but I’ve noticed the same thing happening to me lately. And I’d only been eating 2 meals and one snack a day to begin with. Now I find that if I have the snack, I don’t even want supper. Or else I just skip the snack altogether.
I can’t keep up.
——————+
It’s funny. I’m so glad I hesitated and didn’t load up on pistachios. Or tart cherry juice concentrate. And now I’ve finally got my little package of melatonin, and I think I’ve got more than enough for the rest of my life now! To whom will I bequeath what is left? LOL It’s quite ironic. So, pardon me if I hold off on buying any butyrate. Isn’t that the one folks are saying smells like something died?
Despite Kats’ acolytes repeating the “we are each an experiment of one” mantra, it seems like he is conducting his own experiment on thousands simultaneously. I hope he isn’t trying to find a one size fits all approach. It’s clear to me that there is no such animal.
DO NOT OPEN THE BUTYRATE CAP!
Do you speak from experience? 🤪
Don’t worry, I won’t be getting any!
I'm enjoying the pistachios and dried tart cherries are a welcome addition to my life, regardless of Niatonin.
It's all good.
60P/2750N in the morning and then N3K in the afternoon. No ill effects, but I don’t notice anything about my third eye opening.
I do notice that my typing has improved, however. I make fewer random errors.
Smells like my dads' shoes who was a meat cutter, 'cept worse. I opened a cap just to see, and couldn't get that stank off my fingers for a whole day. It may be a way to curb smoking I found, however.
I went all the way to 4000N for a couple of days and the runs came back, so I ran back from that. Maybe that’s what they mean by “third eye” opening. LOL. We’re settling into a maintenance dose at my house of 15M/1000N twice daily.
N3K again for me this morning, with 60P. I’m beginning to feel an overload, so I may start cutting back as well — and see if I can move to 1.5% melatonin instead of pistachios.
That’s close to where I’m settling on with the N as well. However, I’ve been thinking outside of the box on the M. I’ve been drinking just the N, and using the M on my skin. No reason it can’t enter the body from there, I figured. Always had a sneaking suspicion it was the M in the mixture that was making me gassy and bloated. So far it appears that I was right. I notice no more or less tingling than when I mixed them, either.
So I mixed the M into pure aloe vera gel, as I had done once before, but thinned it out this time with a little colloidal silver, and made a larger quantity. My skin feels nice and soft when I use this, too!
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