Posted on 09/09/2021 6:58:17 AM PDT by numberonepal
Niacin and Melatonin work in synergy. The melatonin opens the gateway to cells and the inflammation within the cells. Niacin gets inside and kicks the crap out of it. We are all depleted of melatonin, so everyone's doses are different.
The Sweet Spot is when there is No Flush. Not even a tingle occurs. Hence, all the melatonin is being used up as well as the niacin to remove inflammation and restore the cells to homeostasis. The Flush is when excess niacin is not being used by the melatonin and goes to the skin capillaries.
The environmental stresses of modern life can lead to shortages of nutrients, especially melatonin and niacin, leading to the accumulation of free radicals and inflammation. The virus was targeted to affect the ACE2 receptors, which are regulated by melatonin and niacin. Once in your cells the virus consumes your energy, depletes melatonin, down-regulates the ACE2 receptors (especially in the intestines producing a leaky gut) giving the virus and spikes easy access to your brain and nervous system through the Vagus nerve.
The virus thrives in a melatonin/niacin deficient environment. The virus uses the energy from inflammation for its fitness (fuel). Supplementing melatonin and niacin reduces the inflammation that makes your body more vulnerable and reactivates your immune system to take care of the virus.
Over the course of life the lack of nutrients, especially melatonin and niacin, can't counter the progression of bad health behaviors throughout that life. New exposures like electronics, geothermal shifts, etc, a stressful life and poorer quality food these days all compound these deficiencies. Our continued dynamic deficiency in especially NIATONIN (niacin/melatonin) leads to the accumulation of more energy not expended out as per in. Because of this free radical electrons form and inflammation accumulates.
It's literally like the virus and covid pathogenesis, just slower.
These viruses or their gain of function research - whatever you want to imagine it is - have evolved since SARS-1 in 2000 to target these energy receptors; aka ACE2; what niacin and melatonin regulate.
It's a feasting ground for them (viruses).
Note:
Niacin and melatonin regulate ACE2 (Angiotensin-converting enzyme 2).
ACE2 is an enzyme attached to the membrane of cells located in the intestines, kidney, testis, gallbladder, and heart. ACE2 lowers blood pressure by catalyzing the hydrolysis of angiotensin II into angiotensin.
They're (viruses) thermodynamically attracted to people who have more inflammation for them to use for their fitness (fuel). These high expressed ACE2 (aka niacin receptors) along with the SR-B1 coreceptor right next to it - they (virus) sneak in this.
Note:
SR-B1 is a scavenger receptor class B type 1. It functions as a receptor for high-density lipoprotein. It is also know as CD36, a scavenger receptor class B member 3.
SR-BI/CD36 chimeric receptors define extracellular subdomains of SR-BI critical for cholesterol transport
https://pubmed.ncbi.nlm.nih.gov/25211142/
The SR-B1 is where HDL dumps off cholesterol from blood into tissue to prevent atherosclerosis. Because the cholesterol was leaking out of the tissue after it reached threshold, it can not contain it anymore due to too much pressure. As a result, HDL lowers because it's not getting developed in the liver anymore. The HDL has to attend to scooping more cholesterol back into tissue, and is used up real quick.
The virus then gets in cells and as it literally continues to consume your energy until it reaches a threshold it needs of energy to double (replicate). As it does this it depletes melatonin. It also makes it a lot easier if you have deficient melatonin. You can see now why unhealthy and older people who have not had enough melatonin and niacin as most at risk. They also have low HDL/high TG (triglycerides). The depleted melatonin makes the PDC receptor, already stunted from accumulated inflammation over a lifetime, from pyruvate to Acetyl-CoA even more stunted. Due to this melatonin gets gradually even more depleted into say long haul COVID. As soon as the virus meets threshold to replicate it moves out the mitochondria, and on to the next one (cell) like a bad ex-girlfriend. Repeat forward. This is why COVID long haulers flush like crazy with even 50 mg doses of niacin.
Note:
• Type I interferons (IFNs) derived from plasmacytoid dendritic cells (PDCs) are critical for antiviral responses
• Pyruvic acid or pyruvate is a key intermediate in the glycolytic and pyruvate dehydrogenase pathways, which are involved in biological energy production.
• Acetyl-CoA is a molecule that participates in many biochemical reactions in protein, carbohydrate and lipid metabolism.
As the virus leaves each cell, it and all the crazy inflammation it amplified [hypered], leaves melatonin depleted and stunts further the PDC from pyruvate to acetylCoA. This is needed for AAANAT receptor from tryptophan to serotonin to melatonin stunted too, and so melatonin isn't made more and more.
Note:
The key regulatory step in melatonin synthesis is catalyzed by arylalkylamine N-acetyltransferase (AANAT), which converts serotonin to N-acetylserotonin.
This leaves ACE2 downregulated, and happens especially in the intestines/colon.
This is how the virus/spikes - like IVM gains easy access to your brain/nervous system then - your gut becomes leaky with this ravaging of melatonin and inflammation. This gives easy access through the Vagus nerve to cross into BBB (blood brain barrier) and nervous systems where the most bang for the buck energy is for them.
Basically the virus/spikes have to deplete your already deficient melatonin and niacin to succeed and be thermodynamically attracted in the first place.
So keeping NIATONIN sufficient/repleting it takes back control of YOUR energy metabolism that the spikes try to take over for their food (energy).
It (NIATONIN) doesn't just push out inflammation. It allows T-cell differentiation (melatonin through ACE2 aka GPR109A expression). Then niacin comes in which is literally an innate/mandatory function of the recruitment and facilitation of T-cells, killer cells, and B cells. It induces phagocytosis, denatures, kills, and clears the virus as well as all pathogens and all toxins. It's a feasting grounds for them.
Note:
GPR109A (encoded by Niacr1) is a receptor for butyrate in the colon. GPR109A is also a receptor for niacin, which is also produced by gut microbiota and suppresses intestinal inflammation.
https://pubmed.ncbi.nlm.nih.gov/24412617/
NIACIN: https://purebulk.com/products/niacin-vitamin-b3-immediate-release?sca_ref=1004090.8JspdBHd04…
MELATONIN: https://purebulk.com/products/melatonin?sca_ref=1004090.8JspdBHd04…
Precision (0.000 g) Scale: https://purebulk.com/products/gemini-20-digital-scale?sca_ref=1004090.8JspdBHd04…
This graphic contains the protocol. Please read it all, especially the top portion where is says to eliminate certain things while using the protocol.
Niacin is OK with heat? I'm glad to know that since it's been a struggle to get the niacin to dissolve in room-temperature water.
This is a soft simmer, like 90C. It does need some heat to dissolve well. It's not going to be hot enough to damage the molecule.
Dietary Sources and Bioactivities of Melatonin https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC5409706/The confusion seems to be with the unit "ng" (the abbreviation for nanograms, or billionths of a gram). My annotations in [brackets].Mushrooms, like white ones, Agaricus bisporus, have 4300-6400 ng/g of melatonin.
Though, this same study found pistachios contain ~230000ng/g of melatonin, considerably more (350x?) than the other study.
Coffee beans weigh in at 1mg/bean (whole) so maybe chocolate covered espresso beans might be a good source...(8000ng/g * 0.125g/bean)
Black pepper has 1mg/g too.
Coffee brewed is 60mg/L. Perhaps it’s better to drink 20 cups a day after all...
Mushrooms, like white ones, Agaricus bisporus, have 4300-6400 ng/g of melatonin.
[This is 4.3-6.4 micrograms/g, or 0.0043-0.0064 mg/g. It would take 1000 g of mushrooms (2.2 lbs) to get 5 mg of melatonin.]
Though, this same study found pistachios contain ~230000ng/g of melatonin, considerably more (350x?) than the other study.
[This translates to 0.23 mg/g, or 6 mg for the typical 50P dose.]
Coffee beans weigh in at 1mg/bean (whole) so maybe chocolate covered espresso beans might be a good source...(8000ng/g * 0.125g/bean)
[8000 ng/g is 8 micrograms/g, or 0.008 mg/g, so one bean is about 0.001 or 1/1000 of a mg of melatonin
Black pepper has 1mg/g too.
[Again, probably 0.001 mg/g]
Coffee brewed is 60mg/L. Perhaps it’s better to drink 20 cups a day after all...
[With the above figure for coffee beans, we're now talking 0.06mg/liter, so you would need 16 liters of coffee to get 1 mg!]
My conclusion: only pistachios seem to have a significant amount of melatonin. Everything else, with respect to melatonin content, is a pisoshito. Unless you really like mushrooms.
I saw someone(s) mentioning cranberries, too, on the Telegram chat. I like Craisins. Had a dish of mixed pistachios, Craisins and almonds for a snack yesterday. Mmmmm!
Re: dosage memage -
Sheesh... and now I’m reading on the Tele chat where sum people be wantin’ to mix Niatonin and psychedelic mushrooms...
While the Kats away, the mice will play.
Me, I don’ wanna be trippin’. I just wanna get rid of these dang eye floaters... ;-)
This article says that "dried cranberries provide up to 0.096 milligrams of melatonin per gram." Unfortunately, Craisins are over half sugar so you'd have to factor that in. If you generously assigned Craisins 0.05 mg melatonin/gram, then you would need 20 g of Craisins to get 1 mg. To get the 6 mg that are in 50 pistachios, you would need about 120 g or roughly a quarter pound of Craisins -- which will also include more than 2.5 oz, or 15 teaspoons, of sugar. (According to the ingredients, 40 g of Craisins contain 27 g sugar.)
During a self-improvement webinar today, a woman mentioned that she had had COVID twice. I talked to her afterwards. For her second bout, she spent $14K (including $7K on credit cards) on doctors to get real treatment, which did at least include ivermectin, zinc, vitamin D, quercetin, etc. Massive quantities of zinc finally brought her taste and smell back.
I told her the basics of the Niatonin story and pointed her to the website. Unfortunately, she's allergic to pistachios, but perhaps she'll try the pure melatonin approach. She thinks she become allergic to pistachios by eating them every day for a long while. That's something we might all be concerned about, so we should definitely be looking for alternatives that we can rotate among.
If, as I have theorized, there's some mystery ingredient(s) in cherries that helps activate melatonin, perhaps we could combine cherries with a small amount of melatonin powder to provide the amount needed for the Niatonin effect.
It seems like you're headed in the right direction. This article (about non-surgical ways of getting rid of eye floaters) suggests:
Floaters are a bear. I’ve heard people on the board talking about floaters being diminished. I haven’t noticed a change in mine. We’ll see what happens.
bkmk
OK, I ate 1oz. of Pistachios. That was 52 naked nuts. I took 250mg of Niacin. No flush, zip, nada. I did it after lunch.
I did the the Niatonin + acupuncture experiment again today. When I woke up from the one-hour acu-nap, it wasn’t anything special but as I lay there for a few minutes, the pure transcendental bliss effect returned and persisted for 10 or 15 minutes, until the lovely Miss Kate had to make room for another client. If anything, the feeling was even stronger this time. As I left the clinic my heart was bursting with joy.
By the way, I moved up from 1000N to 1200N today, with 60-70P and a banana. Very minor flushing: warming around the ears, slight itch in the forearms.
Oh, and weight loss close to 4 lbs now.
Um, like wow.
Bewm! I think that’s prolly too many stachios. Only one way to find out. Try 500 and same nuts. That’s a quarter cup. That’s going to get old fast. I’m doing a half cup roughly for 2000 and I can barely chew anymore as I do it thrice today. Been making the wife a pistachio “shake” that has about 1/2 cup stachios in 1 cup milk and some honey. Maybe I should switch to that as it easier to get them in you. I’m thinking the holiday spices might be a good add.
Warmth around the eyes. Did 50 min in an IR sauna (Hotworx) afterward.
Does it have to be a huge dose of Niacin to work?
I guess what I’m asking is, can 500mg a day of the flush niacin be dangerous or is it only the other niacin that is dangerous at high amounts? I know you explained how it works somewhere up thread but has anybody had bloodwork done after taking that much to check liver values? Did I read that at the right dosage each they cancel each other out?
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