Posted on 09/09/2021 6:58:17 AM PDT by numberonepal
Niacin and Melatonin work in synergy. The melatonin opens the gateway to cells and the inflammation within the cells. Niacin gets inside and kicks the crap out of it. We are all depleted of melatonin, so everyone's doses are different.
The Sweet Spot is when there is No Flush. Not even a tingle occurs. Hence, all the melatonin is being used up as well as the niacin to remove inflammation and restore the cells to homeostasis. The Flush is when excess niacin is not being used by the melatonin and goes to the skin capillaries.
The environmental stresses of modern life can lead to shortages of nutrients, especially melatonin and niacin, leading to the accumulation of free radicals and inflammation. The virus was targeted to affect the ACE2 receptors, which are regulated by melatonin and niacin. Once in your cells the virus consumes your energy, depletes melatonin, down-regulates the ACE2 receptors (especially in the intestines producing a leaky gut) giving the virus and spikes easy access to your brain and nervous system through the Vagus nerve.
The virus thrives in a melatonin/niacin deficient environment. The virus uses the energy from inflammation for its fitness (fuel). Supplementing melatonin and niacin reduces the inflammation that makes your body more vulnerable and reactivates your immune system to take care of the virus.
Over the course of life the lack of nutrients, especially melatonin and niacin, can't counter the progression of bad health behaviors throughout that life. New exposures like electronics, geothermal shifts, etc, a stressful life and poorer quality food these days all compound these deficiencies. Our continued dynamic deficiency in especially NIATONIN (niacin/melatonin) leads to the accumulation of more energy not expended out as per in. Because of this free radical electrons form and inflammation accumulates.
It's literally like the virus and covid pathogenesis, just slower.
These viruses or their gain of function research - whatever you want to imagine it is - have evolved since SARS-1 in 2000 to target these energy receptors; aka ACE2; what niacin and melatonin regulate.
It's a feasting ground for them (viruses).
Note:
Niacin and melatonin regulate ACE2 (Angiotensin-converting enzyme 2).
ACE2 is an enzyme attached to the membrane of cells located in the intestines, kidney, testis, gallbladder, and heart. ACE2 lowers blood pressure by catalyzing the hydrolysis of angiotensin II into angiotensin.
They're (viruses) thermodynamically attracted to people who have more inflammation for them to use for their fitness (fuel). These high expressed ACE2 (aka niacin receptors) along with the SR-B1 coreceptor right next to it - they (virus) sneak in this.
Note:
SR-B1 is a scavenger receptor class B type 1. It functions as a receptor for high-density lipoprotein. It is also know as CD36, a scavenger receptor class B member 3.
SR-BI/CD36 chimeric receptors define extracellular subdomains of SR-BI critical for cholesterol transport
https://pubmed.ncbi.nlm.nih.gov/25211142/
The SR-B1 is where HDL dumps off cholesterol from blood into tissue to prevent atherosclerosis. Because the cholesterol was leaking out of the tissue after it reached threshold, it can not contain it anymore due to too much pressure. As a result, HDL lowers because it's not getting developed in the liver anymore. The HDL has to attend to scooping more cholesterol back into tissue, and is used up real quick.
The virus then gets in cells and as it literally continues to consume your energy until it reaches a threshold it needs of energy to double (replicate). As it does this it depletes melatonin. It also makes it a lot easier if you have deficient melatonin. You can see now why unhealthy and older people who have not had enough melatonin and niacin as most at risk. They also have low HDL/high TG (triglycerides). The depleted melatonin makes the PDC receptor, already stunted from accumulated inflammation over a lifetime, from pyruvate to Acetyl-CoA even more stunted. Due to this melatonin gets gradually even more depleted into say long haul COVID. As soon as the virus meets threshold to replicate it moves out the mitochondria, and on to the next one (cell) like a bad ex-girlfriend. Repeat forward. This is why COVID long haulers flush like crazy with even 50 mg doses of niacin.
Note:
• Type I interferons (IFNs) derived from plasmacytoid dendritic cells (PDCs) are critical for antiviral responses
• Pyruvic acid or pyruvate is a key intermediate in the glycolytic and pyruvate dehydrogenase pathways, which are involved in biological energy production.
• Acetyl-CoA is a molecule that participates in many biochemical reactions in protein, carbohydrate and lipid metabolism.
As the virus leaves each cell, it and all the crazy inflammation it amplified [hypered], leaves melatonin depleted and stunts further the PDC from pyruvate to acetylCoA. This is needed for AAANAT receptor from tryptophan to serotonin to melatonin stunted too, and so melatonin isn't made more and more.
Note:
The key regulatory step in melatonin synthesis is catalyzed by arylalkylamine N-acetyltransferase (AANAT), which converts serotonin to N-acetylserotonin.
This leaves ACE2 downregulated, and happens especially in the intestines/colon.
This is how the virus/spikes - like IVM gains easy access to your brain/nervous system then - your gut becomes leaky with this ravaging of melatonin and inflammation. This gives easy access through the Vagus nerve to cross into BBB (blood brain barrier) and nervous systems where the most bang for the buck energy is for them.
Basically the virus/spikes have to deplete your already deficient melatonin and niacin to succeed and be thermodynamically attracted in the first place.
So keeping NIATONIN sufficient/repleting it takes back control of YOUR energy metabolism that the spikes try to take over for their food (energy).
It (NIATONIN) doesn't just push out inflammation. It allows T-cell differentiation (melatonin through ACE2 aka GPR109A expression). Then niacin comes in which is literally an innate/mandatory function of the recruitment and facilitation of T-cells, killer cells, and B cells. It induces phagocytosis, denatures, kills, and clears the virus as well as all pathogens and all toxins. It's a feasting grounds for them.
Note:
GPR109A (encoded by Niacr1) is a receptor for butyrate in the colon. GPR109A is also a receptor for niacin, which is also produced by gut microbiota and suppresses intestinal inflammation.
https://pubmed.ncbi.nlm.nih.gov/24412617/
NIACIN: https://purebulk.com/products/niacin-vitamin-b3-immediate-release?sca_ref=1004090.8JspdBHd04…
MELATONIN: https://purebulk.com/products/melatonin?sca_ref=1004090.8JspdBHd04…
Precision (0.000 g) Scale: https://purebulk.com/products/gemini-20-digital-scale?sca_ref=1004090.8JspdBHd04…
This graphic contains the protocol. Please read it all, especially the top portion where is says to eliminate certain things while using the protocol.
Reading up on it more, I don’t think cherries are a significant source of melatonin. Montmorency cherries have about 13.5 nanograms (billionths of a gram) in one gram of fruit flesh, so you would need to eat about 60 kg of fresh pitted cherries to get one milligram of melatonin.
By comparison, IIRC, pistachio nuts (dried, no shell) have about 6.6 mg melatonin per oz or about 1/4 mg melatonin per gram. Thus you would need to eat about 4 grams of pistachio to get one milligram of melatonin.
IF tart cherries help people get to sleep, it can’t just be the melatonin. By the way, Rainier cherries have about six times as much melatonin as Montmorency cherries — still not a significant source. You would only need to eat 10 kg of Rainier cherries to get 1 mg of melatonin.
(The last sentence ended up in the wrong paragraph when first posted.)
ph
I did your calculation and only came up with 66.363636. :-)
However by that time I had already shelled 75 pistachios, chopped them up and added them to a half of a mashed avocado with a spritz of lemon juice and a dash of cayenne pepper. (An experiment I won’t try again unless I find unsalted pistachios. Other than being too salty, it had a good flavor, though.)
But be that as it may, I now have had similar things to compare - 2 days back to back, each with 75 pistachios, followed shortly by 500m Niacin powder. Yesterday I added 200m melatonin powder after the pistachios, and only had a slight ear and face tingle for 20 minutes. Today I decided to forego the melatonin powder completely, to see what would happen. Well, I had a massive flush, and was red all over from head to toe for an hour!
Sometime last week, I did similar numbers as yesterday, minus any pistachios, and just got a small tingle of short duration, as well.
My conclusion - the pistachios don’t work as well as the powder, for me. Is the powder more bioavailable to me? What other conclusion can I make, however illogical it sounds? But that’s where I am. Go figure!
My experiment today was intended to be 50P/30min/500N. It was a dirty experiment. After I bought the pistachios this morning, I probably had 25 or more on the way home — because I like pistachios. Around 2 pm I ate 50 more, chewing very well because I figured that would help with “processing”. I set my watch alarm for half an hour, but I got distracted when the alarm went off, so it was probably another hour before I actually took the niacin. I had a few more pistachios just to make sure.
I had a nice nap this evening, but I feel like my melatonin overload is dissipating.
The result was probably the mildest and most diffuse flush feeling I have experienced. Instead of the usual warm tingle around my ears, I had the feeling of a warm halo around my head which gradually descended down through my shoulders and out into my forearms. No tingle or discomfort.
And you just used the pistachios as your only melatonin source? Lucky you! I envy you! I don’t mind the flushes per se, but it’s just that the synergy isn’t there and less is being accomplished, especially with a heavy flush. So I feel it was a failure in that respect.
If the pistachios are so full of melatonin, why don’t they make me sleepy like the powders do, I wonder?
I know what you mean about chewing them thoroughly. When I ate them plain yesterday, it took me over a half hour just to eat them, for that reason. Same thing when I ate them mixed with the avocado, actually. I usually eat meals much faster than that!
Yes, though I wonder how much melatonin was still in my body from all those previous experiments. I'm guessing that my effective dose given the delays was 50P-60P.
I'm going to try stepping up the niacin from 500 to 1000 mg while increasing the pistachios proportionally. If I get up to 1000, I will then try stepping back the pistachios to find a minimum effective P dose.
If the pistachios are so full of melatonin, why don’t they make me sleepy like the powders do, I wonder?
The pistachios actually have far less melatonin, so there must be some magic ingredient in the pistachios that makes the melatonin useful rather than just sleep-inducing. Perhaps some of us make that magic ingredient naturally, while others have to consume pistachios to get it.
If pistachios generally made people sleepy, they'd have to have a warning label.
That’s a darn good price on pistachios.
And yes, I could have done the math like that, but most wouldn’t know where the numbers came from.
The next best thing for natural mellie is almonds and it’s a lot less (can’t remember the number) than pistachios. You’d have to eat lots of almonds compared to pistachios. On the other hand tart cherry juice is delicious and can’t hurt for mellie buildup.
I didn’t glean what your flush was like from the pistachios. And I can’t tell if you are mixing powder and pistachios. Don’t do that.
Pro tip: much on them throughout the day.
Yes. The flush (intentional) was different for me too. It felt deeper and not so close to the skin as before. I felt it in my joints and bones it seemed. It wasn’t uncomfortable, but it was there. Further, the flush was long delayed as compared to powdered mellie.
To be clear, I only used pistachios yesterday. I can't say exactly how many, but it could have been 100 or more total, spread through the day. I did P50 at 2 pm, intending to take 500N at 2:30, but I didn't take the niacin (and a few more pistachios) until around 3:30.
This is what I reported afterward, ICYMI:
"The result was probably the mildest and most diffuse flush feeling I have experienced. Instead of the usual warm tingle around my ears, I had the feeling of a warm halo around my head which gradually descended down through my shoulders and out into my forearms. No tingle or discomfort."
My brother commented: "100 pistachios and you see God? Cheap date ..."
I didn’t glean what your flush was like from the pistachios. And I can’t tell if you are mixing powder and pistachios. Don’t do that.
As to “munching throughout the day” (of anything, for that matter), it’s a habit I’ve never acquired, and my lifestyle really doesn’t allow for... sounds like my husband, always snacking on something, whatever he’s doing. Ugh, I can’t even imagine... I eat 2 meals, and one snack in between. The rest of the time, I like my teeth clean. LOL
Right now I feel all pistachio’d out, frankly. Shame that it happened. Too much of a good thing in too short a time frame, I guess. It happens. I’ll have to come back slowly, or I’ll end up hating them. Tonight I’ll try with the powders alone.
Sorry for replying to the message that was meant for you. It must be due to my melatonin fog.
Borrowing from the immortal words of Rita Hayworth, “Put the blame on Mellie, boys, put the blame on Mellie.”
By the way, the fog seems to have cleared this morning.
No worries, I understand!
I’ve had a craving for apples, as I hadn’t eaten any for a couple weeks (they’ve been part of my afternoon snack, and too close to supper and subsqeuent niatonin dosing). I’m a creature of habit, yes! lol So I decided to have 2 apples sliced and dipped in peanut butter for breakfast, instead. Yes, I’m just now eating breakfast at 1:15. (That’s perfectly normal for eccentric moi.) I guess I’ll have the rest of my fruit/nut combo late this afternoon instead.
I’ve been slightly “bugged” by the alterations to my previous normal eating and supplementation routines. In particular, not taking quercetin. It’s not like I began taking it when everybody did last year, but I’d been taking it for 20 years. They really helped with my allergies of unknown origin here in south FL. And now my nose has been running a lot more. Maybe it’s my body ridding itself of the mysterious “gunk”? I don’t know any more...
“100 pistachios and you see God? Cheap date ...”
That’s going on the Telegram board.
Can you find a three hour period in between doses to eat an apple? Make time for the Honey Crisp.
There is a price for ridding the inflammation. Many prices it seems. I'm finally over "the purge" from the gut. Ugh.
Sure, if I break my established routines and quit going OCD about them. ;-)
What’s the Honey Crisp? Sorry, no comprendo eso.
It gets better. Today I got up, had some pistachios, had some breakfast, had some more pistachios, washed the bedroom and bathroom floors, and just had time for 600N before heading off to an acupuncture appointment. I had a very mild flush on the way, but it had completely calmed down by the time I got to the clinic.
The lovely Miss Kate diagnosed my heel/sole problem as plantar fasciitis, and proceeded to stick needles on the palm side of one hand (for the fasciitis in my foot) and on the back of the other hand and in both feet. As usual I slept for almost exactly an hour, but when I woke up I experienced something completely different.
Usually when I awake from my acu-nap, I feel pretty good. After all, it’s a nap. But this time I awoke in the midst of pure transcendental bliss, like I had never experienced before. My entire body was immersed in pure pleasure, from head to toe — and no, apart from the needles, Miss Kate was not involved. It went on for 15 or 20 minutes.
I don’t know if this had anything to do with the niacin, but you can be assured there WILL be more experiments.
OMG you don’t know what a Honey Crisp apple is? It is the crispiest and sweetest apple there is. They are special (and expensive) apples. They are stored in a zero oxygen environment. That way they can be doled out over the year. Kinda looks like a Fuji, but not mealy like that.
Glory be!
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