Posted on 09/09/2021 6:58:17 AM PDT by numberonepal
Niacin and Melatonin work in synergy. The melatonin opens the gateway to cells and the inflammation within the cells. Niacin gets inside and kicks the crap out of it. We are all depleted of melatonin, so everyone's doses are different.
The Sweet Spot is when there is No Flush. Not even a tingle occurs. Hence, all the melatonin is being used up as well as the niacin to remove inflammation and restore the cells to homeostasis. The Flush is when excess niacin is not being used by the melatonin and goes to the skin capillaries.
The environmental stresses of modern life can lead to shortages of nutrients, especially melatonin and niacin, leading to the accumulation of free radicals and inflammation. The virus was targeted to affect the ACE2 receptors, which are regulated by melatonin and niacin. Once in your cells the virus consumes your energy, depletes melatonin, down-regulates the ACE2 receptors (especially in the intestines producing a leaky gut) giving the virus and spikes easy access to your brain and nervous system through the Vagus nerve.
The virus thrives in a melatonin/niacin deficient environment. The virus uses the energy from inflammation for its fitness (fuel). Supplementing melatonin and niacin reduces the inflammation that makes your body more vulnerable and reactivates your immune system to take care of the virus.
Over the course of life the lack of nutrients, especially melatonin and niacin, can't counter the progression of bad health behaviors throughout that life. New exposures like electronics, geothermal shifts, etc, a stressful life and poorer quality food these days all compound these deficiencies. Our continued dynamic deficiency in especially NIATONIN (niacin/melatonin) leads to the accumulation of more energy not expended out as per in. Because of this free radical electrons form and inflammation accumulates.
It's literally like the virus and covid pathogenesis, just slower.
These viruses or their gain of function research - whatever you want to imagine it is - have evolved since SARS-1 in 2000 to target these energy receptors; aka ACE2; what niacin and melatonin regulate.
It's a feasting ground for them (viruses).
Note:
Niacin and melatonin regulate ACE2 (Angiotensin-converting enzyme 2).
ACE2 is an enzyme attached to the membrane of cells located in the intestines, kidney, testis, gallbladder, and heart. ACE2 lowers blood pressure by catalyzing the hydrolysis of angiotensin II into angiotensin.
They're (viruses) thermodynamically attracted to people who have more inflammation for them to use for their fitness (fuel). These high expressed ACE2 (aka niacin receptors) along with the SR-B1 coreceptor right next to it - they (virus) sneak in this.
Note:
SR-B1 is a scavenger receptor class B type 1. It functions as a receptor for high-density lipoprotein. It is also know as CD36, a scavenger receptor class B member 3.
SR-BI/CD36 chimeric receptors define extracellular subdomains of SR-BI critical for cholesterol transport
https://pubmed.ncbi.nlm.nih.gov/25211142/
The SR-B1 is where HDL dumps off cholesterol from blood into tissue to prevent atherosclerosis. Because the cholesterol was leaking out of the tissue after it reached threshold, it can not contain it anymore due to too much pressure. As a result, HDL lowers because it's not getting developed in the liver anymore. The HDL has to attend to scooping more cholesterol back into tissue, and is used up real quick.
The virus then gets in cells and as it literally continues to consume your energy until it reaches a threshold it needs of energy to double (replicate). As it does this it depletes melatonin. It also makes it a lot easier if you have deficient melatonin. You can see now why unhealthy and older people who have not had enough melatonin and niacin as most at risk. They also have low HDL/high TG (triglycerides). The depleted melatonin makes the PDC receptor, already stunted from accumulated inflammation over a lifetime, from pyruvate to Acetyl-CoA even more stunted. Due to this melatonin gets gradually even more depleted into say long haul COVID. As soon as the virus meets threshold to replicate it moves out the mitochondria, and on to the next one (cell) like a bad ex-girlfriend. Repeat forward. This is why COVID long haulers flush like crazy with even 50 mg doses of niacin.
Note:
• Type I interferons (IFNs) derived from plasmacytoid dendritic cells (PDCs) are critical for antiviral responses
• Pyruvic acid or pyruvate is a key intermediate in the glycolytic and pyruvate dehydrogenase pathways, which are involved in biological energy production.
• Acetyl-CoA is a molecule that participates in many biochemical reactions in protein, carbohydrate and lipid metabolism.
As the virus leaves each cell, it and all the crazy inflammation it amplified [hypered], leaves melatonin depleted and stunts further the PDC from pyruvate to acetylCoA. This is needed for AAANAT receptor from tryptophan to serotonin to melatonin stunted too, and so melatonin isn't made more and more.
Note:
The key regulatory step in melatonin synthesis is catalyzed by arylalkylamine N-acetyltransferase (AANAT), which converts serotonin to N-acetylserotonin.
This leaves ACE2 downregulated, and happens especially in the intestines/colon.
This is how the virus/spikes - like IVM gains easy access to your brain/nervous system then - your gut becomes leaky with this ravaging of melatonin and inflammation. This gives easy access through the Vagus nerve to cross into BBB (blood brain barrier) and nervous systems where the most bang for the buck energy is for them.
Basically the virus/spikes have to deplete your already deficient melatonin and niacin to succeed and be thermodynamically attracted in the first place.
So keeping NIATONIN sufficient/repleting it takes back control of YOUR energy metabolism that the spikes try to take over for their food (energy).
It (NIATONIN) doesn't just push out inflammation. It allows T-cell differentiation (melatonin through ACE2 aka GPR109A expression). Then niacin comes in which is literally an innate/mandatory function of the recruitment and facilitation of T-cells, killer cells, and B cells. It induces phagocytosis, denatures, kills, and clears the virus as well as all pathogens and all toxins. It's a feasting grounds for them.
Note:
GPR109A (encoded by Niacr1) is a receptor for butyrate in the colon. GPR109A is also a receptor for niacin, which is also produced by gut microbiota and suppresses intestinal inflammation.
https://pubmed.ncbi.nlm.nih.gov/24412617/
NIACIN: https://purebulk.com/products/niacin-vitamin-b3-immediate-release?sca_ref=1004090.8JspdBHd04…
MELATONIN: https://purebulk.com/products/melatonin?sca_ref=1004090.8JspdBHd04…
Precision (0.000 g) Scale: https://purebulk.com/products/gemini-20-digital-scale?sca_ref=1004090.8JspdBHd04…
This graphic contains the protocol. Please read it all, especially the top portion where is says to eliminate certain things while using the protocol.
Mark
I love them but do they come in a low calorie version? :-)
I don’t think you need a truck load. They’re so much more bioavailable. Try the powdered mellie in gel caps to delay release in the gut. That may also help with doses that are high.
I’m thinking anything fermented might be an interesting vector to pursue. Clif High just did a vidya on fermentation called Buttermilk Woo.
https://www.bitchute.com/video/F0YiYRG8hYkO/
You eat a handful of these and it will curb your appetite for sure.
Later.!
Follow
LOL, I put a big bag in my grocery cart for the next online pickup. I love them but they are one of those things that if I eat half a cup I end up eating the whole bag. I’ll have to work on my self control.
Getting the kind in the shells can help control. LOL.
Yep. You spend a lot of time and energy shucking them.
Funnily enough, my desire for beer or wine has diminished a lot over the last couple years. I used to have 3 or 4 beers or glasses of wine per week, now I don’t even do that much in a month. I can believe they’ve got melatonin, though, as they always makes me sleepy and I can only drink them at night.
I don’t know what changed. I’ve always been a “follow my instinct” kind of person when it comes to eating and drinking. I eat when I’m hungry, drink when thirsty and stop when I’m full, mostly. And I think I can say it’s served me well (though it’s the complete opposite of my husband’s habits. But what else is new?)
I discovered over a week ago that the only way to take the powdered melatonin is to put it in caps. Too harsh on the throat to swallow otherwise. Burns.
As to the truckload of pistachios. I meant that to keep me going for a while, assuming I could eat enough of them to help, and still have room left over for other food. I don’t want to go on a monodiet of pistachios! But, since 50 did nothing to curb my flush. I have a hunch that mere 3 lb. bags would be used up in short order.
If Dr Dimitry gets serious about planting a pistachio farm somewhere, then he should seriously think about concocting some kind of highly concentrated pistachio extract, with all the good stuff and no added fillers or flavors. I’d buy that!
So yesterday I ended my break which only lasted a day. I definitely felt much better low-dosing again. The higher dose I’d reached previously (375M 800N) was making me feel loopy, but back down to 200M and 500N, I was actually quite energetic. Only felt a very minor tingle on my ears and face that didn’t last more than 20 minutes. I exercised vigorously for almost an hour, weight training with dumbbells and then doing over 600 reps on my ab-lounger out on the patio. Not bad. Slept well, woke up refreshed.
Some Maffs:
Basically a 1lb (453g) bag of pistachios contains about 100mg or highly bioavailable melatonin. Example: I normally had to take 150mg melatonin with 750mg niacin to not flush. Today I ate about 30g (50) of pistachios and 750mg niacin and no flush.
1 pistachio carries about 0.22mg of melatonin. If I ate 50 pistachios, I ingested approximately 11mg melatonin. You can see that supplement melatonin is inferior in a big way to getting from a natural source. That’s an 11/150 ratio. Take your normal mellie dose and multiply it by .073, then divide that by .22 and that will give you the rough number of pistachios to eat.
Nice to hear. Now switch to pistachios. I’m betting you’ll be eating less than a half ounce of pistachios. See my post about a rough calculation.
Interesting math.
The literature says that melatonin has about 3% “bioavailability” when taken by mouth in pure form, with typical variations from 1.5% to 4.5%. For the past few days I’ve been taking about 600 mg of melatonin with my gram of niacin. (I have to say that this has greatly reduced my energy, even though I still have a mild flush.
I’ll assume that my body utilizes melatonin at the lower end of the range, so that 600 mg makes 1.5% * 600 = 9 mg available for use in my body. Dividing by .22, that suggests I need about 40 pistachios for my 1000 mg of niacin.
For the first time, I’m going to be super careful and try 40P with only 500N.
You're at the low end of mg melatonin use, so you have a high bioavailability factor, which you basically calculated to be 7.3% (assuming that 100% of the melatonin in pistachios is bioavailable). I need a lot of oral melatonin, which is why I estimated my bioavailability factor at 1.5%.
Another odd "coincidence" today: while listening to the radio on the way back from my morning pistachio shopping trip to Costco, I heard an ad for some new brand of tart cherry juice, extolling its provision of antioxidants, anti-inflammatories, and -- drum roll -- melatonin. They actually recommended tart cherry juice (presumably Montmorency cherries) as a sleep aid.
I don't know how many cherries are equivalent to a pistachio, but this might be another way to get your melatonin. If I'd known before my shopping trip, I would have picked up some dried Montmorency cherries at Costco while getting my pistachios.
Another by-the-way: our Costco does not sell unsalted pistachios, so I bought their 1.5 lbs of no-shell pistachios for $13.99. A 1-oz serving ("approx. 49 kernels") has about 7% of the RDA for sodium. I also bought a 12-oz bag of "lightly salted" pistachios at Target for $11.99. A 1-oz serving of those has about 3% of the RDA for sodium. Almost twice the money -- less than half the salt.
Reading up on it more, I don’t think cherries are a significant source of melatonin. Montmorency cherries have about 13.5 nanograms (billionths of a gram) in one gram of fruit flesh, so you would need to eat about 60 kg of fresh pitted cherries to get one milligram of melatonin.
By comparison, IIRC, pistachio nuts (dried, no shell) have about 6.6 mg melatonin per oz or about 1/4 mg melatonin per gram. Thus you would need to eat about 4 grams of pistachio to get one milligram of melatonin. You would only need to eat 10 kg of Rainier cherries to get 1 mg of melatonin.
IF tart cherries help people get to sleep, it can’t just be the melatonin. By the way, Rainier cherries have about six times as much melatonin as Montmorency cherries — still not a significant source.
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