Posted on 09/09/2021 6:58:17 AM PDT by numberonepal
Niacin and Melatonin work in synergy. The melatonin opens the gateway to cells and the inflammation within the cells. Niacin gets inside and kicks the crap out of it. We are all depleted of melatonin, so everyone's doses are different.
The Sweet Spot is when there is No Flush. Not even a tingle occurs. Hence, all the melatonin is being used up as well as the niacin to remove inflammation and restore the cells to homeostasis. The Flush is when excess niacin is not being used by the melatonin and goes to the skin capillaries.
The environmental stresses of modern life can lead to shortages of nutrients, especially melatonin and niacin, leading to the accumulation of free radicals and inflammation. The virus was targeted to affect the ACE2 receptors, which are regulated by melatonin and niacin. Once in your cells the virus consumes your energy, depletes melatonin, down-regulates the ACE2 receptors (especially in the intestines producing a leaky gut) giving the virus and spikes easy access to your brain and nervous system through the Vagus nerve.
The virus thrives in a melatonin/niacin deficient environment. The virus uses the energy from inflammation for its fitness (fuel). Supplementing melatonin and niacin reduces the inflammation that makes your body more vulnerable and reactivates your immune system to take care of the virus.
Over the course of life the lack of nutrients, especially melatonin and niacin, can't counter the progression of bad health behaviors throughout that life. New exposures like electronics, geothermal shifts, etc, a stressful life and poorer quality food these days all compound these deficiencies. Our continued dynamic deficiency in especially NIATONIN (niacin/melatonin) leads to the accumulation of more energy not expended out as per in. Because of this free radical electrons form and inflammation accumulates.
It's literally like the virus and covid pathogenesis, just slower.
These viruses or their gain of function research - whatever you want to imagine it is - have evolved since SARS-1 in 2000 to target these energy receptors; aka ACE2; what niacin and melatonin regulate.
It's a feasting ground for them (viruses).
Note:
Niacin and melatonin regulate ACE2 (Angiotensin-converting enzyme 2).
ACE2 is an enzyme attached to the membrane of cells located in the intestines, kidney, testis, gallbladder, and heart. ACE2 lowers blood pressure by catalyzing the hydrolysis of angiotensin II into angiotensin.
They're (viruses) thermodynamically attracted to people who have more inflammation for them to use for their fitness (fuel). These high expressed ACE2 (aka niacin receptors) along with the SR-B1 coreceptor right next to it - they (virus) sneak in this.
Note:
SR-B1 is a scavenger receptor class B type 1. It functions as a receptor for high-density lipoprotein. It is also know as CD36, a scavenger receptor class B member 3.
SR-BI/CD36 chimeric receptors define extracellular subdomains of SR-BI critical for cholesterol transport
https://pubmed.ncbi.nlm.nih.gov/25211142/
The SR-B1 is where HDL dumps off cholesterol from blood into tissue to prevent atherosclerosis. Because the cholesterol was leaking out of the tissue after it reached threshold, it can not contain it anymore due to too much pressure. As a result, HDL lowers because it's not getting developed in the liver anymore. The HDL has to attend to scooping more cholesterol back into tissue, and is used up real quick.
The virus then gets in cells and as it literally continues to consume your energy until it reaches a threshold it needs of energy to double (replicate). As it does this it depletes melatonin. It also makes it a lot easier if you have deficient melatonin. You can see now why unhealthy and older people who have not had enough melatonin and niacin as most at risk. They also have low HDL/high TG (triglycerides). The depleted melatonin makes the PDC receptor, already stunted from accumulated inflammation over a lifetime, from pyruvate to Acetyl-CoA even more stunted. Due to this melatonin gets gradually even more depleted into say long haul COVID. As soon as the virus meets threshold to replicate it moves out the mitochondria, and on to the next one (cell) like a bad ex-girlfriend. Repeat forward. This is why COVID long haulers flush like crazy with even 50 mg doses of niacin.
Note:
• Type I interferons (IFNs) derived from plasmacytoid dendritic cells (PDCs) are critical for antiviral responses
• Pyruvic acid or pyruvate is a key intermediate in the glycolytic and pyruvate dehydrogenase pathways, which are involved in biological energy production.
• Acetyl-CoA is a molecule that participates in many biochemical reactions in protein, carbohydrate and lipid metabolism.
As the virus leaves each cell, it and all the crazy inflammation it amplified [hypered], leaves melatonin depleted and stunts further the PDC from pyruvate to acetylCoA. This is needed for AAANAT receptor from tryptophan to serotonin to melatonin stunted too, and so melatonin isn't made more and more.
Note:
The key regulatory step in melatonin synthesis is catalyzed by arylalkylamine N-acetyltransferase (AANAT), which converts serotonin to N-acetylserotonin.
This leaves ACE2 downregulated, and happens especially in the intestines/colon.
This is how the virus/spikes - like IVM gains easy access to your brain/nervous system then - your gut becomes leaky with this ravaging of melatonin and inflammation. This gives easy access through the Vagus nerve to cross into BBB (blood brain barrier) and nervous systems where the most bang for the buck energy is for them.
Basically the virus/spikes have to deplete your already deficient melatonin and niacin to succeed and be thermodynamically attracted in the first place.
So keeping NIATONIN sufficient/repleting it takes back control of YOUR energy metabolism that the spikes try to take over for their food (energy).
It (NIATONIN) doesn't just push out inflammation. It allows T-cell differentiation (melatonin through ACE2 aka GPR109A expression). Then niacin comes in which is literally an innate/mandatory function of the recruitment and facilitation of T-cells, killer cells, and B cells. It induces phagocytosis, denatures, kills, and clears the virus as well as all pathogens and all toxins. It's a feasting grounds for them.
Note:
GPR109A (encoded by Niacr1) is a receptor for butyrate in the colon. GPR109A is also a receptor for niacin, which is also produced by gut microbiota and suppresses intestinal inflammation.
https://pubmed.ncbi.nlm.nih.gov/24412617/
NIACIN: https://purebulk.com/products/niacin-vitamin-b3-immediate-release?sca_ref=1004090.8JspdBHd04…
MELATONIN: https://purebulk.com/products/melatonin?sca_ref=1004090.8JspdBHd04…
Precision (0.000 g) Scale: https://purebulk.com/products/gemini-20-digital-scale?sca_ref=1004090.8JspdBHd04…
This graphic contains the protocol. Please read it all, especially the top portion where is says to eliminate certain things while using the protocol.
That is awesome. I bet you sleep like a baby.
Let go of the "melatonin is for sleep" dogma. It's way more crucial than that. With the Protocol you will use up all the melatonin with the niacin. This is the internal barometer we use to determine how much melatonin to use. If not enough, you flush - take more melatonin. If too much, you're groggy - take more niacin. We're looking for the sweet spot where you feel NOTHING.
I do. I also take cbd drops and prescribed transdermal progesterone before bed. Really good sleep.
Protocol Update:
For folks with inverted ratios (more melatonin than niacin), Dr. Kats is now suggesting putting the melatonin in a gel cap to delay absorption. From testimonial evidence, the people with inverted ratios are having problems finding sweet spots and reversing the ratio. The thinking is the melatonin in powder form is being used up quickly in the GI tract due to severe depletion (double/triple jabbed and long Covid people usually). In a nutshell the melatonin is not being absorbed, it’s being put to work as soon as it hits the gut. Therein the gel cap for delayed absorption.
This will increase the time between melatonin and niacin doses to 30-45 minutes. Your mileage may vary. The DOES NOT mean to use time release melatonin pills and premade capsules. IF you re t very high doses of melatonin, you could go through a whole bottle of melatonin in a day. And the fillers in those pills would stack up like cord wood. Blech. He’s saying make your own capsules and use the gel caps, not veggie caps.
I will monitor the board and see what happens.
https://t.me/vaccinereversal
My Niatonin dose #13, last night: 600M/30min/1000N. This was the tiniest flush so far, just a slight warming around the forehead. Slight drowsiness.
I used two veggie caps for the melatonin.
Started making caps for them both several days ago, because the taste was getting to me. Didn’t seem to make a difference, as I was in a low-dose sweet spot at the time at approx 1:2.5 ratio. What did make a difference was when I upped the dose somewhat. I couldn’t quite get rid of the tingle, even with a smaller ratio, and last night I went back to low-dose because I had an early morning this morning and didn’t want to risk it. Couldn’t find my (former) sweet spot at low dose, where I’d gotten it three times in a row last week. Sigh.
So the sweet spot is being elusive now, and seems neither dependent on ratio nor dosage. I should have kept track of what I’d eaten for supper, as well, maybe that has something to do with it! Who knows anymore... and I have no idea what I will try tonight. Sometimes they talk on the Telegram chat about taking it after a “big meal”... tonight I’m having meat and potatoes, which is extremely unusual for me (maybe one or 2 times a month), usually it’s just a salad or vegetarian supper. Should I go lo or hi... or flip a coin. LOL
You are almost at a sweet spot. Noice. However, they are suggesting the gelatin caps. That’s a big change for Kats because he railed against gel caps in the beginning. But I reckon you have the melatonin in caps from the store. What melatonin dosage is in each cap? At 600M I’m guessing it’s high.
You’ll have less severe flushes if you stay high niacin and adjust mellie. This happened to me when we dropped our dosage. Sweet spot ratio was not right and had a surprisingly big flush. It got to my knees.
I haven’t had a “severe” flush though, since before I found the sweet spot the first time. Just assorted non-tingly hotness to minor tingles without anything being visibly red, ears-face-neck and very occasionally arms. May happen quickly after taking niacin, or an hour after. But it’s still there, albeit slight, and the goal is for it do disappear completely, which is what’s eluding me at either high doses or low ones these days.
How long does it take to get an order from PureBulk? I ordered melatonin from them on the 28th, and so far they’ve only prepared the shipping label. They must be swamped.
And now PISTACHIOS! Does this Protocol get any better. Kats is recommending eating a bunch of pistachios for low/inverted ratio people because they are high in melatonin that’s probably more bioavailable than powdered melatonin. 1lb pistachios contains about 100mg melatonin. There’s like 30 mg melatonin in a 4 oz bag of pistachios. The kind still in the shell are best because they are protected from light. For those on a high mellie dose this could supplement the supplement.
Kats said he ate 50 pistachios with lunch and then after about 30 mins ate 1000mg Niacin and no flush. That equated to about 6mg melatonin from the pistachios. He’s thinking the bioavailability of the melatonin in the pistachios equates to about 3X what you would get from a supplement. If you’re at a low mellie dose with high niacin this is worth a shot I think.
What’s the Melatonin Content of Pistachios?
https://www.healthline.com/nutrition/pistachios-melatonin
Note: in article they say “More than 30 mg of supplemented melatonin could be potentially harmful”. That’s total BS, and they may be required to say it.
The Physiological Function of Melatonin in Plants
https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC2635004/
I don’t know. I placed an order a couple weeks ago and it’ hasn’t come. I’m finding niacin powders to be different in graininess and curios about PureBulk.
Yum. I prefer raw ones. I will add to list. I can probably handle melatonin in food form. :-D
Pistachios for dessert it is, then! I wish I had some pistachio ice cream.... mmmmmmmm!
I already had "00" veggie caps for use with essential oils. I measured out 600 mg melatonin and squeezed it into two caps, with a little overflow, which I just mixed in with water.
I'll try 550M/1000N this evening.
Well, that was a dud! I love them, but the pistachio protocol is a pisoshito for me.
(I wanted to use those words in the same sentence! lol)
I ate 50 of the nuts, and then took 700mg of niacin about 25 minutes later. In record time, I felt a real, bonafide flush coming on, and I had to take a bunch of melatonin in a hurry - lost track how much - close to 350 maybe? - just to tame it down to a tolerable tingle.
Oh well. Back to the drawing board. Just as well, because even eating about 20 P a day as I normally do with my late afternoon snacks, I feel guilty because the price on them has skyrocketed so high lately!
Between meat, potatoes and pistachios, I am too stuffed tonight. Will have to make it an all smoothie day tomorrow to make up for it...
Interesting about bioavailability. The essential oils company I use has done a lot of research on that topic, and has generally found ways to increase bioavailability by about 2.5x by compounding with essential oils. As an extreme example, with turmeric, they have been able to boost the bioavailability of curcumin by 24x using essential oils.
It doesn't seem to be the case with melatonin, at least for sleep. Their sleep aid has 3.2 mg of melatonin, which is about par for the course with melatonin supplements. Their super-B complex has 35 mg of niacin, which is at the top end of the recommended dose range for niacin, so it doesn't seem like they're accomplishing any bioavailability miracles with either melatonin or niacin. Once I find my sweet spot, I may play around with essential oils to see if they make a difference.
Dietary Sources and Bioactivities of Melatonin
https://www.ncbi.nlm.nih.gov/labs/pmc/articles/PMC5409706/
Mushrooms, like white ones, Agaricus bisporus, have 4300-6400 ng/g of melatonin.
Though, this same study found pistachios contain ~230000ng/g of melatonin, considerably more (350x?) than the other study.
Coffee beans weigh in at 1mg/bean (whole) so maybe chocolate covered espresso beans might be a good source...(8000ng/g * 0.125g/bean)
Black pepper has 1mg/g too.
Coffee brewed is 60mg/L. Perhaps it’s better to drink 20 cups a day after all...
Yeah, if you are that high a dose of mellie, the pistachios would just be a supplement.
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