Posted on 09/09/2021 6:58:17 AM PDT by numberonepal
Niacin and Melatonin work in synergy. The melatonin opens the gateway to cells and the inflammation within the cells. Niacin gets inside and kicks the crap out of it. We are all depleted of melatonin, so everyone's doses are different.
The Sweet Spot is when there is No Flush. Not even a tingle occurs. Hence, all the melatonin is being used up as well as the niacin to remove inflammation and restore the cells to homeostasis. The Flush is when excess niacin is not being used by the melatonin and goes to the skin capillaries.
The environmental stresses of modern life can lead to shortages of nutrients, especially melatonin and niacin, leading to the accumulation of free radicals and inflammation. The virus was targeted to affect the ACE2 receptors, which are regulated by melatonin and niacin. Once in your cells the virus consumes your energy, depletes melatonin, down-regulates the ACE2 receptors (especially in the intestines producing a leaky gut) giving the virus and spikes easy access to your brain and nervous system through the Vagus nerve.
The virus thrives in a melatonin/niacin deficient environment. The virus uses the energy from inflammation for its fitness (fuel). Supplementing melatonin and niacin reduces the inflammation that makes your body more vulnerable and reactivates your immune system to take care of the virus.
Over the course of life the lack of nutrients, especially melatonin and niacin, can't counter the progression of bad health behaviors throughout that life. New exposures like electronics, geothermal shifts, etc, a stressful life and poorer quality food these days all compound these deficiencies. Our continued dynamic deficiency in especially NIATONIN (niacin/melatonin) leads to the accumulation of more energy not expended out as per in. Because of this free radical electrons form and inflammation accumulates.
It's literally like the virus and covid pathogenesis, just slower.
These viruses or their gain of function research - whatever you want to imagine it is - have evolved since SARS-1 in 2000 to target these energy receptors; aka ACE2; what niacin and melatonin regulate.
It's a feasting ground for them (viruses).
Note:
Niacin and melatonin regulate ACE2 (Angiotensin-converting enzyme 2).
ACE2 is an enzyme attached to the membrane of cells located in the intestines, kidney, testis, gallbladder, and heart. ACE2 lowers blood pressure by catalyzing the hydrolysis of angiotensin II into angiotensin.
They're (viruses) thermodynamically attracted to people who have more inflammation for them to use for their fitness (fuel). These high expressed ACE2 (aka niacin receptors) along with the SR-B1 coreceptor right next to it - they (virus) sneak in this.
Note:
SR-B1 is a scavenger receptor class B type 1. It functions as a receptor for high-density lipoprotein. It is also know as CD36, a scavenger receptor class B member 3.
SR-BI/CD36 chimeric receptors define extracellular subdomains of SR-BI critical for cholesterol transport
https://pubmed.ncbi.nlm.nih.gov/25211142/
The SR-B1 is where HDL dumps off cholesterol from blood into tissue to prevent atherosclerosis. Because the cholesterol was leaking out of the tissue after it reached threshold, it can not contain it anymore due to too much pressure. As a result, HDL lowers because it's not getting developed in the liver anymore. The HDL has to attend to scooping more cholesterol back into tissue, and is used up real quick.
The virus then gets in cells and as it literally continues to consume your energy until it reaches a threshold it needs of energy to double (replicate). As it does this it depletes melatonin. It also makes it a lot easier if you have deficient melatonin. You can see now why unhealthy and older people who have not had enough melatonin and niacin as most at risk. They also have low HDL/high TG (triglycerides). The depleted melatonin makes the PDC receptor, already stunted from accumulated inflammation over a lifetime, from pyruvate to Acetyl-CoA even more stunted. Due to this melatonin gets gradually even more depleted into say long haul COVID. As soon as the virus meets threshold to replicate it moves out the mitochondria, and on to the next one (cell) like a bad ex-girlfriend. Repeat forward. This is why COVID long haulers flush like crazy with even 50 mg doses of niacin.
Note:
• Type I interferons (IFNs) derived from plasmacytoid dendritic cells (PDCs) are critical for antiviral responses
• Pyruvic acid or pyruvate is a key intermediate in the glycolytic and pyruvate dehydrogenase pathways, which are involved in biological energy production.
• Acetyl-CoA is a molecule that participates in many biochemical reactions in protein, carbohydrate and lipid metabolism.
As the virus leaves each cell, it and all the crazy inflammation it amplified [hypered], leaves melatonin depleted and stunts further the PDC from pyruvate to acetylCoA. This is needed for AAANAT receptor from tryptophan to serotonin to melatonin stunted too, and so melatonin isn't made more and more.
Note:
The key regulatory step in melatonin synthesis is catalyzed by arylalkylamine N-acetyltransferase (AANAT), which converts serotonin to N-acetylserotonin.
This leaves ACE2 downregulated, and happens especially in the intestines/colon.
This is how the virus/spikes - like IVM gains easy access to your brain/nervous system then - your gut becomes leaky with this ravaging of melatonin and inflammation. This gives easy access through the Vagus nerve to cross into BBB (blood brain barrier) and nervous systems where the most bang for the buck energy is for them.
Basically the virus/spikes have to deplete your already deficient melatonin and niacin to succeed and be thermodynamically attracted in the first place.
So keeping NIATONIN sufficient/repleting it takes back control of YOUR energy metabolism that the spikes try to take over for their food (energy).
It (NIATONIN) doesn't just push out inflammation. It allows T-cell differentiation (melatonin through ACE2 aka GPR109A expression). Then niacin comes in which is literally an innate/mandatory function of the recruitment and facilitation of T-cells, killer cells, and B cells. It induces phagocytosis, denatures, kills, and clears the virus as well as all pathogens and all toxins. It's a feasting grounds for them.
Note:
GPR109A (encoded by Niacr1) is a receptor for butyrate in the colon. GPR109A is also a receptor for niacin, which is also produced by gut microbiota and suppresses intestinal inflammation.
https://pubmed.ncbi.nlm.nih.gov/24412617/
NIACIN: https://purebulk.com/products/niacin-vitamin-b3-immediate-release?sca_ref=1004090.8JspdBHd04…
MELATONIN: https://purebulk.com/products/melatonin?sca_ref=1004090.8JspdBHd04…
Precision (0.000 g) Scale: https://purebulk.com/products/gemini-20-digital-scale?sca_ref=1004090.8JspdBHd04…
This graphic contains the protocol. Please read it all, especially the top portion where is says to eliminate certain things while using the protocol.
I’m trying to make a more readable and understandable version of the “Supporting Factors” section from the Niatonin site. Here’s my first attempt:
Supporting Factors
Diet: Ancestral (higher fat/low carb), non-processed diet providing bioavailable copper (refer to Root Cause Protocol).
Exercise: Brisk walk or better for 5 hours/wk.
Meditation/spiritual exercises; especially important for jab treatment.
NAC (1.2x your niacin dose) aids niacin vs. clotting, promotes glutathione more efficiently than glutathione supplementation, provides antioxidation. NAC helps niacin preserve mitochondrial health. See if it helps. It benefits many, but many don’t need very much.
L-Glutamine (5-10 g / 1-2x daily) may expedite acute recovery for adults & in long COVID. Use as needed/helpful. Likely only a few doses necessary as replenished melatonin quickly restores depleted glutamine;
Magnesium: Glycinate version (400-500 mg, 1-3x daily) recommended to promote glutathione. Adjust for children by weight.
B1/thiamine (extra 50-300 mg/day of HCL version) helps in long haul to restore depleted mitochondrial melatonin.
B2, B6 as P-5-P, folate, B12 as provided in methyl B-complex (50- or 100-version once daily or every other day. Adjust for children by weight.)
Niacinamide/nicotinamide from B-complex & food, sufficient for NAD+ salvage.
TMG betaine (trimethylglycine), in 3:4 TMG:niacin ratio, for methylation support & to lower/prevent high homocysteine;
Bioavailable vitamin C (400-1000 mg, 1-3x daily — adjust dosing for children). Source from Innate Response or whole foods (orange/guava).
Mixed tocopherols vitamin E (1 dose daily)
Selenium yeast (1 dose daily or every other day)
Vitamin D from the sun (supplementation may not replenish properly)
Dandelion tea with lemon peel (cup a day)
For additional metal chelation, beyond what melatonin does: curcumin, actoferrin, copper bisglycinate (2 mg, 1-2x daily), zeolite, fulvic acid, IP6 (inositol).
IR sauna for 1-2 hours after niatonin/exercise.
Good stuff. Someone has done the entire graphic in text on the Telegram channel. I’ll try to find it and bring it over.
Is ‘flush niacin’ just a name for the dose of regular niacin?
NIATONIN Protocol by Dmitry Kats
Flush Niacin + Melatonin taken shortly apart, with supporting factors
CONTRAINDICATIONS/DISCLAIMER
• Within 3-hours do not take aspirin, apples (pectin) quecertin, antihistamines, alcohol, Rx (most not needed anyways)
• Consult/monitor with your medical provider before/during
• Apparent side effects can be avoided
PRIMARY RESOURCES
Powder form Niacin & Melatonin are best. Weigh, mix in water, drink. Use code DMITRYKATS at purebulk.com to save 10%.
• Immediate release flush Niacin (Vitamin B3)
(https://purebulk.com/products/niacin-vitamin-b3-immediate-release?sca_ref=1004090.8JspdBHd04)• Melatonin (https://purebulk.com/products/melatonin?sca_ref=1004090.8JspdBHd04)
• Precision (0.000 g) milligram Scale
(https://purebulk.com/products/gemini-20-digital-scale?sca_ref=1004090.8JspdBHd04)• Tiny Measuring Spoons to Scoop
Protection / General Maintenance / Pre-jab - Individualized per mass, age, sensitivity, health status. Try adapting below-listed doses 1-3x per day to comfort
| | Niacin | Melatonin |
| | (mg) | (mg) |
|-———|—————|-—————|
| Adult | 500-1500 | 6-30 |
| Teen | 375-750 | 3-9 |
| Child | 50-375 | 2-6 |
| Baby | 25 | 1 |
Acute COVID-19 and/or Jab Injury Recovery - Dose-response therapeutic effects (assess by severity). Administer below-listed doses 2-3x daily. Transition to Protection protocol once recovered
| | Niacin | Melatonin |
| | (mg) | (mg) |
| Adult | 750-2000 | 15-40 |
| Teen | 500-1250 | 9-18 |
| Child | 250-750 | 6-12 |
| Baby | 1-3 | 1-3 |
Prolonged aka “Long” COVID Recovery - Start near lower cusp of below doses and creep up along recovery. If non-flush reaction: from to 25-75mg and titrate up. Administer below-listed doses 2-3x daily. Transition to Protection protocol once recovered
| | Niacin | Melatonin |
| | (mg) | (mg) |
| Adult | 500-1500 | 18-50 |
| Teen | 375-750 | 9-20 |
| Child | 100-375 | 6-15 |
| Baby | 25-75 | 1.5-5 |
SUPPORTING FACTORS
• Ancestral (ie: higher fat/low carb), not processed diet providing bio-available copper (refer to: ROOT CAUSE protocol
• Leisure-time exercise (at a level of at least a brisk-walk, for 5 h/wk)
• Meditation/spiritual exercises
• NAC (especially important for jab treatment). NAC aids niacin vs. clotting (NAC:niacin ratio 6:5), promotes glutathione/antioxidation, is synergistic with niacin to preserve mitochondrial health
• l-Glutamine 5-10g/1-2x daily, may expedite acute recovery for adults given its drop as niacin dumps along acute phase upon unleashing of cytokines storm, and in long COVID (as it may remain deficient thereon). Note: If it is needed/helpful, likely only a few doses as melatonin repletion should quickly restore depleted glutamine
COFACTORS
• magnesium (glycinate best for flycine to promote glutathione) 400-500mg, 1-3x daily (adjust accordingly for children/mass)
• B Vitamins (B1 (thiamine (extra 50-300 mg doses of HCL version is fine) becomes advantageous in long haul to restore extensively depleted mitochondrial melatonin), B2, B6 as P-5-P, folate, B12) as provided in ‘methyl’ B-complex (50 or 100 version (adjust accordingly for children/mass) once daily or every other day, niacinamide/nicotinamide from B-complex & food sufficient for NAD+ salvage) + TMG/betaine (7.5:10 TMG:niacin ratio) for methylation support & to lower/prevent high homocysteine
• Bioavailable Vitamin C (400-1000 mg/1-3x daily; adjust dosing for children. Innate Response, whole foods; orange/guava
• Mixed tocopherols vitamin E (once daily)
• Selenium yeast (once daily or every other day)
• Vitamin D from the sun (supplementation may not replenish properly)
• Dandelion tea + lemon peel (cup a day)
FOR MORE METAL CHELATION (in addition to melatonin)
• Curcumin
• Lactoferrin
• Copper Biglycinate (2mg/1-2x daily)
• Zeolite
• Fulvic Acid
• IP6
• IR Sauna 1-2 h after taking NIATONIN/exercise
Am I the only one who finds the taste of these supplement powders to be nastier and nastier the longer they take them? I’ve finally given in, and am putting them into capsules for round numbers (100mg melatonin, 500mg niacin) just so that I only need to put the “overage” amounts into water/juice to drink, and it isn’t quite as yucky to get down!
I wonder what causes this phenomenon. Am I getting a more heightened sense of taste?
Salty language warning. Dr Kats’ interesting perspective.
2 minute voice clip.
Are “repurposed drugs” all a planned, intentional scripted part of the BigPharma scam?
He thinks so.
https://t.me/vaccinereversal/71973
In the last couple weeks, Dmitry Kats made another fine tuning of the protocol to start with with butyrate to open the melatonin receptor, followed by the melatonin, then the niacin. Each step nominally 10 minutes apart. I have a magnesium-calcium-butyrate on order. There are also sodium and potassium products where that is more suitable for the individual.
I hit my "sweet spot" today with 20 mg melatonin/500 mg niacin and no pins and needles with the flush. If you have too little niacin, the melatonin makes you sleepy. Too much niacin and the flush comes with itchy pins and needles.
Are you dissolving in water or eating the powder and chasing with water? The mellie doesn't have much taste and the niacin is sorta sour, but not awful. The NAC (if you're doing it) is very sour.
DO NOT put in gelatin capsules. If you are going to encapsulate make sure they are the vegan ones. Also, you might want to space the time between mellie and niacin to make sure the capsule has dissolved.
I mix them in water (or diluted juice), then chase with more water. This won’t work when I raise the amounts, sorry! No way on this earth could I “eat” these powders! LOL And au contraire, the melatonin, while maybe the flavor itself is less nasty than the niacin, the brand I have (Liftmode) definitely leaves an acid burn at the back of my throat that lingers for quite a while. Maybe PureBulk is better? I ordered some of that the other day. (And I know NAC is nasty - the capsules even smell nasty!) But, capsules for all from now on.
Gelcaps - vegicaps ... can I somehow tell them apart? I have like 5 jars of recycled capsules all mixed up, from a lifetime of caring for dozens of cats, in addition to myself. LOL So unless there’s a way to distinguish, I use what I grab. As someone once asked, what difference does it make? They dissolve very fast. I know this from experience - I’ve belched a cloud of powder into the air right after taking some calcium caps before... TMI, I know. :)
FWIW, I’ve decided against taking butyrate, based on a few factors. People’s testimonials on Dr K’s chat do not encourage me, and I have had zero history of “gut problems” of any sort. I’m nowhere near an inverse sweet spot ratio, and am gonna try bumping it up to 400M and 1000N one of these nights - but I’m nervous that it’ll make me flush again! haha
They caps you have are probably gel caps. They are the least expensive. You might be better off just buying a new bag of “00” which can hold 500mg niacin if you tamp them.
The butyrate addition is still evolving. It is being used for folks that have an inverted ratio (more melatonin than niacin for no flush). I’ve seen it help, but it’s very complicated. I think this is an Achilles Heel to the protocol in general. The reasoning is complicated and so new. There’s very little written for the layman to understand. Kats isn’t helping much on that end because that’s not how his brain works. I’m trying to convince him to enlist some folks to proselytize that have people skills. LOL.
As I said, what I have is a mix of caps, as many of the supplements I take/took/gave to cats said vegicaps on the labels, but they’ve all been dumped unceremoniously into the same jars together. I believe someone said there was a way to tell them apart on another thread. I can’t remember what it was, but I’m not going to buy more when I have hundreds, if not over a thousand, of empty capsules sitting here already. You haven’t even said what’s wrong with taking M or N in a gelcap, and at least some of the time I’ll be taking them in vegicaps. So that’s better than swallowing the powders directly or in water, IMO. ;-)
I have learned I definitely need the high doses of melatonin. Right now, after adding the butyrate in between the melatonin and niacin, I am 1500mel, 500 niacin. I do experience a light flush about 1-2 hours later with this dosing, but it’s a vast improvement over the boiled lobster episodes when I started! So I know I’m on the right path.
I plan to continue, just don’t know what to tweak next!
Kats has some people trying butyrate first, then mellie, then niacin. That has helped bring down the mellie dose. You are going to get the runs if that level of mellie stays for too long. As me how I know.
My experience last night was unusual, as well. (Unfortunately I can only do this once a day in late evening, as I only eat twice, and the first meal is always full of pectin-y fruits!)
I decided to up my sweet spot ratio, but only to 340M and 800N - too chicken to go to 1000 in one fell swoop. Well, an hour went by and nothing happened (my previous flushes had all begun within the first 10 minutes). But then, I got really hot at once, and began to sweat somewhat. Not unpleasant, and not like a prickly or tingly hot either. I didn’t turn pink. Just felt hot while sitting here in front of the computer, all over, and it lasted maybe 20 minutes. The ceiling fan over me felt good, and evaporated the sweat quickly. After this was over, my skin felt quite dry. So did that count as a flush? Who knows what’s going on... every day a new adventure!
Wow. Delayed flush. You could eat some mellie (20-50mg) to calm that. It may have had something to do with food.
Otherwise are you seeing any benefits, Covid aside.
Not really, but it’s so soon (day 12), and I’m not taking high amounts yet, and I’ve been blessed with such good health that there isn’t really any specific improvement that I’m anxiously awaiting. And I assume that in that situation, the benefits would be slow, as well as subtle. I have no idea what the future holds (or even if it holds that I will continue this protocol indefinitely). ;) If anything, I think the thing I’m feeling so far is more mental that physical, but even that is so subjective, isn’t it?
But the way I look at it now is that it can only be a good thing to have our nutrients at the right levels in our bodies. None of us is going to live forever, so this may improve health, but it is not the fountain of youth. The Lord knows how many days He has allotted each one of us, and if I can make it so that I can live fully until that day of my departure, rather than waste away my final months or years in an institution being pumped full of drugs to make me complacent, then so much the better.
Enough philosophizing. I suppose I could have taken more melatonin when that happened, but since the warmth didn’t feel like a usual niacin flush, and it was getting late and I was sort of winding down anyway, I didn’t think of it. Tonight though, I will raise the mel another 30 and keep the niacin at 800 to see what happens.
What did you mean by “It may have had something to do with food”? I sometimes think I should be taking the melatonin considerably earlier than 2 hours after I’ve finished eating, so that it’s actually on a full stomach. That’s the way I’ve always taken my other supplements - right after the meal. And my digestive metabolism is quite fast. I wonder why Dr K. suggests differently for this?
It seems the closer I take to food the less mellie I need. We are an experiment of one.
It gets crazier:
“... there was an amazing crop circle that appeared on July 23rd, 2011 in Wiltshire, United Kingdom. This crop circle that appeared in 2011 had the structure of melatonin (a hormone, produced by the pineal gland among other locations in the human body). Also, very close to Wiltshire, United Kingdom near Stonehenge (located at Amesbury, Salisbury) on August 1, 2013, a crop circle of niacin (also known as vitamin B3) was also observed (see Figure 1) (Daily Mail, 2013). It is interesting to note, that the 2011 melatonin crop circle was only of melatonin with no other circles or other geometric shapes around or encompassing the melatonin molecule. The niacin crop circle found in Figure 1, however, is much more interesting because the niacin molecule is found in a large circle and outside of the larger circle are 9 (nine) other smaller circles.”
https://www.researchgate.net/publication/346444758_The_Niacin_2013_Crop_Circle_A_Chemical_Perspective
“The Molecule Niacin, is also known as nicotinic acid....”
From the crop circle article. Just read on FR about research being done with nicotine to cure covid. France has banned/put a limit on nicotine patches due to a run on them!
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