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What if hydroxychloroquine doesn’t work? What if it does? Right now, we don’t know
STAT ^ | March 27, 2020 | Matthew Herper

Posted on 03/29/2020 10:58:40 AM PDT by Widget Jr

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To: Widget Jr
Dr. Fauci has been consistent on pursing clinical trials to get good results and reliable data, and this is going to take time.

Yeah, and in the meantime he doesn't want doctors to prescribe the cocktain that has proven results in recent weeks (1. Hydroxychloroquine 200mg twice a day for 5 days 2. Azithromycin 500mg once a day for 5 days 3. Zinc sulfate 220mg once a day for 5 days)

I thought the creed was "First do no harm". It isn't "Do nothing". If there is no harm prescribing these drugs to people that contract the virus, I would serious question the motives of the doctor that doesn't. Politics suck.

61 posted on 03/29/2020 11:36:58 AM PDT by Go Gordon (I gave my dog Grady a last name - Trump - because he loves tweets.)
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To: Widget Jr

We know that the Trump pills work to some extent and we know that they might not be the treatment of choice for everyone, including those with heart conditions.

My thought would be is to use the Trump pills for those that will benefit until other treatments come on line. As for patients that the Trump pills may be dangerous? Use carefully unless other treatments options are available.


62 posted on 03/29/2020 11:39:39 AM PDT by abigkahuna (How can you be at two places at once when you are nowhere at all?)
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To: Widget Jr

I thought the Shanghai study used other antivirals as the control, not a placebo.


63 posted on 03/29/2020 11:41:51 AM PDT by Cooter (Radicals always try to force crises because in a crisis, everyone must choose sides. - J. Goldberg)
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To: Widget Jr
No it doesn't. Why are we being flooded with disinformation based on a Chinese study that if it is even real, has idiotic experimental design.

Just read this summary sentence from the article you posted:

"But a second study emerged last week from Shanghai University in China of 30 patients hospitalized for Covid-19. Whether patients received hydroxychloroquine or not, their body temperature returned to normal a day after hospitalization, and the time it took for levels of the virus to become undetectable was comparable. Unlike the study from France, the patients in this study were randomly assigned to either hydroxychloroquine or the control group, which makes the results more reliable."

That should make you wonder. Why did the patients in the study get better nearly instantly, regardless of treatment?

If you read the study, you would see that the patients in the study all got better within a couple of days, even without treatment. In fact, they were either already cured, or nearly so. In essence the Chinese "study", if it is even real, took patients who were essentially cured anyway, gave them medicine, and then noted that the medicine had little effect on their progress - exactly as one would expect for any test administered to patients who at that point at least, didn't need the medicine.

There is no published evidence anywhere that COVID-19 patients are cured in a median of 2 days after diagnosis. But that is exactly what the Chinese research team found for their control group. And the range included 1 day.

"The median duration from hospitalization to virus nucleic acid negative conservation was 4 (1-9) days in HCQ group, which is comparable to that in the control group 2 (1-4) days..."

But no one is reporting that hospitalized COVID-19 patients are recovered and virus free within a median time of 2 days, with some recovering in 1 day, and the longest recovering in 4 days. The patients in the control group had already recovered from the virus. Similarly, the treated patients, except for the 9 day patient, recovered in a median time of 4 days, with one of the patients recovering in one day.

The Chinese paper cited in the article, if it is even real, has an idiotic experimental design. The big question for you, and everyone else hyping it is why is there such a big effort to undercut the research showing hydroxychloroquine does work. So why are you doing that?

Here is the Chinese paper.

64 posted on 03/29/2020 11:47:05 AM PDT by freeandfreezing
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To: Jayster

Some Lupus patients have taken it daily for years.


65 posted on 03/29/2020 11:49:23 AM PDT by Bethaneidh
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To: Widget Jr

So lets find out. Field trials, now.


66 posted on 03/29/2020 11:50:33 AM PDT by Fido969 (In!)
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To: wardaddy
It is good to track down the people hyping the Shanghai study, since it is either Chinese disinformation or the worst designed study ever. See my post in this thread on the details - their control group got better - as in no virus - in from 1 to 4 days.

No other medical group is reporting that untreated COVID-19 patients get better in a couple of days. The patients in the "study" must have already been almost cured.

67 posted on 03/29/2020 11:50:56 AM PDT by freeandfreezing
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To: Widget Jr

This story misses the point.

It’s not hydrocloroquine alone. It’s a combo therapy.


68 posted on 03/29/2020 11:53:08 AM PDT by FlipWilson
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To: Widget Jr

Trial after trial says it does work. Only the stupid woman Governor of Michigan is fighting against it because President Trump mentioned it. Oh did I say she is a democrat?


69 posted on 03/29/2020 11:55:03 AM PDT by maxwellsmart_agent
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To: Batman11

My doc has been giving it to his COVID patients - he said they have been having the same good results


70 posted on 03/29/2020 11:56:35 AM PDT by BookmanTheJanitor
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To: Cooter
The English language text of the article just says "conventional treatment only".

That may be anti-virals or just about anything you can imagine. Perhaps someone who reads Chinese can read the rest of the study and report back to us.

Regardless of what the control group received, they were nearly cured at the start of the study since they had a median time to no virus present of 2 days, with the longest being 4 days. So they were effectively cured in a median time of 2 days, far less than any reported total times for clearing the COVID-19 infection from onset to resolution.

The control group, if the study is real at all, were people who were already cured, and about to be released.

71 posted on 03/29/2020 11:57:42 AM PDT by freeandfreezing
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To: Widget Jr
But a second study emerged last week from Shanghai University in China of 30 patients hospitalized for Covid-19. Whether patients received hydroxychloroquine or not, their body temperature returned to normal a day after hospitalization, and the time it took for levels of the virus to become undetectable was comparable. Unlike the study from France, the patients in this study were randomly assigned to either hydroxychloroquine or the control group, which makes the results more reliable.

Chinese disinformation.

Brought to you by the lying liars of the lying Chinese government, who have been lying about this since November or before.

72 posted on 03/29/2020 12:00:03 PM PDT by kiryandil (Chris Wallace: Because someone has to drive the Clown Car)
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To: Cooter
Here is an example of why a study where the control group is virus free in a median time of 2 days is dealing with people who are already, in effect, cured:


73 posted on 03/29/2020 12:02:29 PM PDT by freeandfreezing
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To: TarasBulbous
because the pharmaceutical golems want their blood money

Gotta pay the vig...

74 posted on 03/29/2020 12:05:40 PM PDT by kiryandil (Chris Wallace: Because someone has to drive the Clown Car)
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To: Widget Jr

The 1 thing we do know is it does work on Malaria, my Dad caught it in the Philippines. When a flare up happened it is what was given. It’s been used off label on Lupus, just as Plaquenil. From the side effects alone I’d have to say it is better than Plaquenil which is very rough on the Lungs. Trashed my niece’s.


75 posted on 03/29/2020 12:08:27 PM PDT by GailA (I'm a Trump Girl)
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To: DesertRhino

Just don’t use Ibuprofen, doesn’t mix well with it..


76 posted on 03/29/2020 12:10:48 PM PDT by GailA (I'm a Trump Girl)
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To: Widget Jr
The antiviral effects of chloroquine have been studied and known for years. This is not a new idea. Writers who write about science often don’t really understand. Even more so when they endeavor to understand and interpret inferential statistics, which is a foreign language for virtually all of them.
77 posted on 03/29/2020 12:12:29 PM PDT by hinckley buzzard (Power is more often surrendered tha)
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To: GailA

I’ve been on an NSAID for a month after cataract surgery. It just ended yesterday. I’ve been really good about staying in because of that. I’m gonna look to see how long it stays in your syste.


78 posted on 03/29/2020 12:16:16 PM PDT by Sacajaweau
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To: nhwingut

Doctors talk to each other. They are prescribing this because it works. The successes are anecdotal - hundreds and hundreds of successful recovery anecdotes. That is how medicine was practiced before the FDA. Based on what is known right now, I would consider it an actionable malpractice to deny this option to a patient.


79 posted on 03/29/2020 12:23:11 PM PDT by jimfree (My19 y/o granddaughter continues to have more quality exec experience than an 8 year Obama.)
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To: Widget Jr

“A few non-clinical trials, doctors using medications on their own, and andanecdotal evidence are not proofs any one cure really works.”

check out these 140 (at the moment) papers published in 2020 regarding treating C-19 with hyroxychorolquine + azithromycin ... how many more studies and papers would you like?

A more important question is: if you or yours fell deathly ill with C-19, would you want those drugs to be tried?

https://scholar.google.com/scholar?as_ylo=2020&q=hydroxychloroquine+covid-19+OR+coronavirus&hl=en&as_sdt=0,6&as_vis=1


80 posted on 03/29/2020 12:25:54 PM PDT by catnipman (Cat Nipman: Vote Republican in 2012 and only be called racist one more time!)
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