Here is a refresher for you.
That to secure these rights, Governments are instituted among Men, deriving their just powers from the consent of the governed, That whenever any Form of Government becomes destructive of these ends, it is the Right of the People to alter or to abolish it, and to institute new Government, laying its foundation on such principles and organizing its powers in such form, as to them shall seem most likely to effect their Safety and Happiness.
Note the key word here, "destructive".
"Destructive" does not mean "at pleasure" or "whenever they see fit", but rather "destructive" means what the rest of the Declaration makes explicit: necessity.
In 1776 it was necessity.
In 1788 it was mutual consent.
Those are the two, and only two, conditions our Founders considered acceptable for disunion.