I won’t carry anything lighter than the 9mm. Even that calibre is very dependent on bullet placement.
I used to carry a Berra Thunder .380 CC but my grip caused it to jam all the time. I'm not a fan of revolvers so my Darlin Husband bought me a Walther P99 with a green Crimson Trace. It fits my hands better and it has never jammed.
I am a big fan of a 9mm now. More stopping power.
Placement of the round you bet.
I took down a huge sow with a .223
Put in her ear. Dead before she hit the ground.
I keep a .380 in my truck and a Taurus Judge (.45/410) in the house.
Hans Ulrich Rudel, Stuka pilot and the highest decorated German soldier of WWII, carried as his personal weapn...a .25 automatic pistol. In a belt holster, he barely noticed it while sitting and strapped into his *office* seat, but it was there if he had to leave his plane behind Russian lines...which he did, at least three times.
He would not have fared well if taken alive by the Soviets. Like a tank crewman prepared in the event he faced burning to death inside a disabled tank, he had the tool that could keep that from happening.