I met my wife in 1978 and started teaching her how to shoot right away. Her favorite pistol was my Colt Gold Cup and she was a fantastic shot.
She now carries a Taurus 24/7 G2 Compact 45ACP. I bought her one in 9mm and she looked at me and said she wanted a 45 so I obliged. She shoots and trains more than enough to use the thumb safety.
Ya, my Gold Cup is tricked out for competition, so everybody loves to shoot it.
Not much for concealed carry though.....
The training I refer to is “stress situation”, which is difficult training to find, especially with the frequency required.
Most of the guys I know don’t use the safety for that reason.
That’s why I qualified my statement noting that women are not usually comfortable carrying w safety off.