[Nebullis]

Although, some people will argue that natural selection is simply working on a hierarchical level above that of the genes, like engrailed and spalt, that produce butterfly wing patterns, namely, at the level of the regulators for those genes.

[Physicist]

Although, some people will argue that natural selection is simply working on a hierarchical level above that of the genes

Precisely. Count me among them. My point, which I failed to make clear, is that natural selection is far more capable than it is usually given credit for, even to the point of making such apparently teleological changes. However, I don't know whether Wolfram is addressing the inadeaquacy of naive gene-at-a-time variation, or has some other hobgoblin in mind.