Actually, evolution has become a hard laboratory science.
http://www.freerepublic.com/focus/f-news/1634489/posts
No guesswork involved.
Yah, I thought of that study but couldn't find the link.
However...
Just to piss people off...
In vivo .NE. in vitro...
which is one of the reasons why so dang many promising pharmacological molecules never even make it TO human trials, let alone to hospital dispensaries... :-)
Cheers!