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Polyphenols in foods we eat can prevent inflammation in older people, since they alter the intestinal microbiota and induce the production of the indole 3-propionic acid (IPA). Polyphenols are natural compounds, considered probiotics, which we eat mainly through fruits and vegetables. The study shows the interaction between polyphenols and gut microbiota can induce the proliferation of bacteria with the ability to synthetize beneficial metabolites, such as IPA, a postbiotic with antioxidant, anti-inflammatory and neuroprotective properties that contributes to improve the health of the intestinal wall. Therefore, this compound would contribute to the prevention of some diseases associated with aging. Researchers...

The immune system remembers. Often this memory, primed by past encounters with threats like bacteria or viruses, is an asset. But when that memory is sparked by internal drivers, like chronic inflammation, it can prove detrimental, perpetuating a misguided immune response. In a new paper, researchers demonstrated that recipients of a bone marrow transplant were predisposed to more severe arthritis if their donor had inflammatory gum disease. The researchers note that this mechanism may also prompt a reconsideration of how bone marrow donors are selected. …To put the whole picture together regarding the link between inflammatory conditions, the "critical experiment,"...

Friends and Freepers, since collectively you know everything there is to know I wonder if any of you have experience with debilitating pain from hip Joint bursitis? Nothing the doctors have tried so far has worked. No arthritis involved.

People who consume sugar and other carbohydrates in excess over a long period of time have an increased risk of developing an autoimmune disease. In affected patients, the immune system attacks the body's own tissue. Their work (shows) excessive consumption of glucose directly promotes the pathogenic functions of certain cells of the immune system and that, conversely, that a calorie-reduced diet can have a beneficial effect on immune diseases. Based on these findings, they also identified new targets for therapeutic interventions: A specific blockade of glucose-depended metabolic processes in these immune cells can suppress excessive immune reactions. Martin Väth explains...

A study has identified a key regulatory mechanism in inflammation that may lead to new targets for resolving that inflammation—and the inflammation of patients with sepsis, cancer and COVID. The scientists discovered a pathway that regulates the immune response after infection or injury, such as burns. Dysregulation of this pathway could differentiate those who are at risk of fatal sepsis or help identify targets to resolve this unregulated inflammation. The team found that the metabolites of linoleic acid formed by the enzyme, soluble epoxide hydrolase (sEH), drive deleterious inflammation after injury. These metabolites, known as lipid mediators, regulate inflammation, blood...

A 32-year-old man from France living in Tokyo was admitted to the National Center for Global Health and Medicine after experiencing shortness of breath and fever. He had received the first dose of the BNT162b2 (Pfizer-BioNTech, https://www.pfizer.comExternal Link) vaccine 5 days before admission. After vaccination, he experienced a fever, systemic joint pain, nausea, and vomiting. The patient sought care because of these persistent symptoms. At admission, the patient was experiencing dyspnea as well as chest and back pain that worsened during inhalation. The patient was obese (body mass index 42.1 kg/m2). He had no history of smoking, illegal drug use,...

The left image shows a knee joint in a healthy rat. (White indicates cartilage.) The second image from the left shows a joint with grade 2 untreated osteoarthritis. The third image shows a joint with osteoarthritis that has worsened from grade 2 to grade 4 after six weeks of placebo therapy. The right image shows a joint with osteoarthritis that improved from grade 2 to grade 1 (mild) after six weeks of combination therapy with alphaKlotho and sTGFbR2. Credit: Salk Institute ***************************************************************** A combination of two previously studied osteoarthritis drugs works better than either drug alone. People with osteoarthritis, or...

IL-6 family proteins can promote inflammation, arthritis, autoimmune disease and even cancer. However, a study reveals the importance of IL-6 and associated genes for maintaining and regenerating cartilage in both the joints and in the growth plates that enable skeletal growth in children. "We show that the IL-6 family, previously associated with arthritis, bone and muscle loss, and other chronic inflammatory diseases, is required for the maintenance of skeletal stem and progenitor cells, and for the healthy growth and function of the joints and spine," said author Denis Evseenko. "Our study establishes a link between inflammation and regeneration, and may...

Results of a study indicate that regularly consuming a diet of pro-inflammatory foods (e.g., those rich in simple carbohydrates or in saturated fats) is associated with increased likelihood of developing frailty in middle-aged and older adults. Frailty affects between 10-15 percent of community-living older adults—making it a significant public health issue. Approximately 1 in 6 community-dwelling older adults will develop frailty, a serious condition of impaired function of ability, which carries increased risk of falls, hospitalizations, and mortality. Previous studies linked specific nutrients with frailty or physical function but did not capture an individual's entire diet and its impact on...

New research from RCSI has demonstrated the significant role that an irregular body clock plays in driving inflammation in the body's immune cells, with implications for the most serious and prevalent diseases in humans. The circadian body clock generates 24-hour rhythms that keep humans healthy and in time with the day/night cycle. This includes regulating the rhythm of the body's own (innate) immune cells called macrophages. When these cell rhythms are disrupted (due to things like erratic eating/sleeping patterns or shift work), the cells produce molecules which drive inflammation. This can lead to chronic inflammatory diseases such as heart disease,...

Four weeks on a diet of highly processed food led to a strong inflammatory response in the brains of aging rats that was accompanied by behavioral signs of memory loss, a new study has found. Researchers also found that supplementing the processed diet with the omega-3 fatty acid DHA prevented memory problems and reduced the inflammatory effects almost entirely in older rats. Neuroinflammation and cognitive problems were not detected in young adult rats that ate the processed diet. The study diet mimicked ready-to-eat human foods that are often packaged for long shelf lives, such as potato chips and other snacks,...

University of South Florida Health-led team discovers that the compound fenchol has the same beneficial effect as gut-derived metabolites in reducing neurotoxic amyloid-beta in the brain. Fenchol, a natural compound abundant in some plants including basil, can help protect the brain against Alzheimer’s disease pathology, a preclinical study led by University of South Florida Health (USF Health) researchers suggests. The new study published on October 5, 2021, in the Frontiers in Aging Neuroscience, discovered a sensing mechanism associated with the gut microbiome that explains how fenchol reduces neurotoxicity in the Alzheimer’s brain. Emerging evidence indicates that short-chain fatty acids (SCFAs)–...

A drug used to treat rheumatoid arthritis has been found to improve survival of hospitalized Covid-19 patients. The discovery comes from a study of over 1,500 Covid-19 patients in 12 countries and is being hailed as a significant breakthrough for treatment options for people who are severely ill with Covid-19. Early on in the pandemic in February 2020, baricitinib was identified as a promising drug to treat Covid-19 by a company using artificial intelligence (AI) and machine learning to identify potential treatments for diseases. The drug, normally used to treat rheumatoid arthritis, was thought to have possible antivirus properties, but...

An enzyme with an elusive role in severe inflammation may be a key mechanism driving COVID-19 severity and could provide a new therapeutic target to reduce COVID-19 mortality, according to a study published in the Journal of Clinical Investigation. sPLA2-IIA, which has similarities to an active enzyme in rattlesnake venom, is found in low concentrations in healthy individuals and has long been known to play a critical role in defense against bacterial infections, destroying microbial cell membranes. When the activated enzyme circulates at high levels, it has the capacity to "shred" the membranes of vital organs, said Floyd (Ski) Chilton....

An Australian journalist has taken to social media after being diagnosed with pericarditis, or inflammation of the heart, due to the Pfizer vaccine. Denham Hitchcock, correspondent and producer for Channel Seven, revealed his condition on Thursday in a post on Instagram, saying no one is talking about the potential side effects of the Pfizer jab amid the current vaccine frenzy. Hitchcock said he initially battled over whether to publish the post, but said after being a journalist for almost three decades, it would be hypocritical for him not to. “It’s clearly happening,” he said, speaking of his condition. “And if...

Researchers have modified standard baking yeast to sense signs of gut inflammation and respond by secreting anti-inflammatory particlesknorre/Depositphotos VIEW 1 IMAGES Researchers from Brigham and Women's Hospital have engineered yeast used in baking, wine-making and brewing to treat inflammatory bowel disease (IBD). The bacteria has been modified to secrete an anti-inflammatory molecule in response to signs of gut inflammation and has proven effective in preclinical tests. Our gut microbiome is increasingly implicated in everything from cancer to neurodegenerative disease but it is still unclear exactly how we can translate these novel findings into clinical treatments. Fecal transplants are probably the...

Antioxidants (Basel). 2020 Jul; 9(7): 624.Published online 2020 Jul 16. doi: 10.3390/antiox9070624PMCID: PMC7402141PMID: 32708578Francesca Silvagno,* Annamaria Vernone, and Gian Piero PescarmonaAuthor information Article notes Copyright and License information DisclaimerThis article has been cited by other articles in PMC. Go to:AbstractThe novel COVID-19 pandemic is affecting the world’s population differently: mostly in the presence of conditions such as aging, diabetes and hypertension the virus triggers a lethal cytokine storm and patients die from acute respiratory distress syndrome, whereas in many cases the disease has a mild or even asymptomatic progression. A common denominator in all conditions associated with COVID-19 appears...

The Centers for Disease Control has announced Thursday that it has scheduled an emergency meeting to discuss increasing reports of myocarditis and pericarditis (heart inflammation) in individuals who had recently received the COVID vaccine, specifically the mRNA Pfizer and Moderna COVID vaccines. The virtual meeting is scheduled for June 18 and will last from 11 a.m. to 5 p.m. Eastern Standard Time. The CDC’s Advisory Committee on Immunization Practices (ACIP) has outlined an agenda for the emergency meeting, which lists several data points uncovered during the investigation previously reported on by National File. The CDC ACIP notes that 488 total...

Asthma affects hundreds of millions of people around the world, but an experimental vaccine offers new hope to successfully treat this chronic lung disease, linked to hundreds of thousands of deaths each year. So far the prototype vaccine has only been tested in animals, but the researchers now intend to conduct a clinical trial in human patients – with hopes the approach could provide a safe, cost-effective, and long-term way to protect people from allergic asthma attacks. "The idea is to set up in the future a preventive approach for populations at risk of developing a severe form of asthma,"...

MRI showing inflammation of the spinal cord. (Roman et al., Frontiers in Immunology, 2021) It feels like it's been a lot longer, but the first case of COVID-19 was officially recorded in December 2019. Researchers are continuing to investigate the full effects of this disease, including unusual ones, and a new analysis has now linked the infection to a rare neurological condition. Acute transverse myelitis (ATM) – an inflammation of the spinal cord which can cause pain, paralysis and sensory problems – was identified in 43 adult COVID-19 cases across 21 countries, with patient ages ranging from 21 to 73,...