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Keyword: inflammation

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  • How a common food ingredient can take a wrong turn, leading to arthritis (Fiber & Med. diet help counter tryptophan indole inflammation)

    03/13/2024 4:13:12 PM PDT · by ConservativeMind · 7 replies
    Medical Xpress / CU Anschutz Medical Campus / Journal of Clinical Investigation ^ | March 8, 2024 | Mark Harden / Brenda J. Seymour et al
    A faculty member and her colleagues have identified the means in which bacteria in the digestive system can break down tryptophan in the diet into an inflammatory chemical that primes the immune system towards arthritis. She says the research "builds upon some observations we had in patients with spondyloarthritis where changes in the microbiome were associated with increased production of indoles, which are what bacteria make from tryptophan." Similar changes were observed in arthritis studies involving mice, she says. "We found that when indole is present, the mice start to develop autoreactive T-cells that are more inflammatory. They have less...
  • Avoid Taking Ibuprofen With This Common Medication At All Costs

    02/27/2024 12:40:35 AM PST · by Jyotishi · 32 replies
    Health Digest ^ | February 26, 2024 | Beth Bradford
    Ibuprofen works wonders for your headaches, joint pain, muscle aches, and menstrual cramps, so it's probably no surprise that it's the second most common over-the-counter (OTC) drug behind paracetamol (Tylenol), according to a 2023 article https://pubmed.ncbi.nlm.nih.gov/36876700/ in the European Review for Medical and Pharmacological Sciences. You might get a prescription for ibuprofen if you have rheumatoid arthritis or osteoarthritis to reduce the pain and swelling from these conditions. Ibuprofen might also be used for psoriatic arthritis, arthritis of the spine, and gouty arthritis. Like other non-steroidal anti-inflammatory drugs (NSAIDs), ibuprofen works by blocking an enzyme that makes prostaglandins that cause...
  • Zinc status is associated with inflammation, oxidative stress, lipid, and glucose metabolism

    12/02/2023 8:30:11 AM PST · by Uncle Miltie · 59 replies
    The Journal of Physiological Sciences ^ | 9/30/2017 (old-ish) | Olechnowicz et al
    Poster's Note: This is a very long article documenting how zinc is Anti: Weight, diabetes, cholesterol, inflammation, oxidation, metabolic syndrome, stroke, atherosclerosis, death, high blood pressure, high blood sugar, cytokines, liver damage, blood vessel damage, kidney damage, etc. I'll post the first dozen paragraphs or so, and you're welcome to follow the link to the extensive article. ------------- A number of studies have reported that zinc plays a substantial role in the development of metabolic syndrome, taking part in the regulation of cytokine expression, suppressing inflammation, and is also required to activate antioxidant enzymes that scavenge reactive oxygen species, reducing...
  • Body changes detected up to eight years before inflammatory bowel disease diagnosis

    11/15/2023 4:09:11 PM PST · by ConservativeMind · 2 replies
    Researchers have shown that changes can be detected in blood tests up to eight years before a diagnosis of Crohn's disease and up to three years before a diagnosis of ulcerative colitis. This means the beginnings of inflammatory bowel diseases start a long time before symptoms occur, and in the future may provide an opportunity for doctors to take preventative action before symptoms begin, or prescribe medication when it will be most effective. Crohn's disease and ulcerative colitis are collectively known as inflammatory bowel diseases (IBD). They are incurable conditions which involve excessive inflammation in the gut, leading to symptoms...
  • Consuming flavonoids helps fight symptoms of endometriosis, researchers find (Quercetin and kaempferol sources)

    11/12/2023 9:24:32 AM PST · by ConservativeMind · 4 replies
    Medical Xpress / Texas A&M University / Endocrinology ^ | Nov. 8, 2023 | Courtney Price / Lei Zhang et al
    Researchers have found a correlation between a compound found in fruits and vegetables and a reduction in the symptoms of endometriosis. In an article, the researchers outline how flavonoids may be able to help suppress the symptoms of inflammatory diseases like endometriosis. In endometriosis, cells similar to those in the lining of the uterus begin growing in other places in the body, causing inflammation. The painful condition affects millions of women, and there is no cure. Flavonoids have been associated with anticancer, antioxidant, anti-inflammatory and antiviral medical benefits, but the details of how they work have remained a mystery. "We...
  • A new connection between the gut microbiota and prostate inflammation in aging men

    11/11/2023 10:31:20 PM PST · by ConservativeMind · 13 replies
    Medical Xpress / Impact Journals LLC / Aging ^ | Nov. 8, 2023 | Weronika Ratajczak et al
    Recent studies indicate that inflammation is one of the causes of the development of benign prostatic hyperplasia (BPH). Inflammation may result from past infections, metabolic disorders, but also from the state of functioning of the intestinal microbiota. In this new study, researchers aimed to assess whether the diagnostic lipid parameters for metabolic syndrome and short-chain fatty acids (SCFAs) are related to the immunoexpression of interleukins in prostate tissue with benign hyperplasia. The study involved 103 men with BPH, who were divided into two groups depending on the presence of MetS. "We analyzed tissue immunoexpression of two proinflammatory interleukins: IL-6, which...
  • Strawberry consumption may reduce dementia risk for middle-aged individuals, study suggests (Just one cup a day)

    11/04/2023 10:12:51 AM PDT · by ConservativeMind · 18 replies
    Medical Xpress / University of Cincinnati / Nutrients ^ | Nov. 1, 2023 | Robert Krikorian et al
    New research has found that daily strawberry consumption could help reduce the risk of dementia for certain middle-aged populations. "Both strawberries and blueberries contain antioxidants called anthocyanins, which have been implicated in a variety of berry health benefits such as metabolic and cognitive enhancements," said Krikorian. "There is epidemiological data suggesting that people who consume strawberries or blueberries regularly have a slower rate of cognitive decline with aging." Krikorian said strawberries contain additional micronutrients called ellagitannins and ellagic acid that have been associated with health benefits. About 50% of individuals in the U.S. develop insulin resistance, commonly referred to as...
  • Study directly links high insulin levels to pancreatic cancer

    11/02/2023 8:11:37 PM PDT · by ConservativeMind · 7 replies
    A study reveals a direct link between high insulin levels, common among patients with obesity and type 2 diabetes, and pancreatic cancer. The study provides the first detailed explanation of why people with obesity and type 2 diabetes are at an increased risk of pancreatic cancer. The research demonstrates that excessive insulin levels overstimulate pancreatic acinar cells, which produce digestive juices. This overstimulation leads to inflammation that converts these cells into precancerous cells. "Alongside the rapid increase in both obesity and type 2 diabetes, we're seeing an alarming rise in pancreatic cancer rates," said Dr. James Johnson. "These findings help...
  • Is red meat intake linked to inflammation?

    11/01/2023 5:31:22 PM PDT · by ConservativeMind · 50 replies
    Inflammation is a risk factor for many chronic diseases, including cardiovascular disease (CVD), and the impact of diet on inflammation is an area of growing scientific interest. In particular, recommendations to limit red meat consumption are often based, in part, on old studies suggesting that red meat negatively affects inflammation—yet more recent studies have not supported this. "The role of diet, including red meat, on inflammation and disease risk has not been adequately studied, which can lead to public health recommendations that are not based on strong evidence," said Dr. Alexis Wood. "Our team sought to take a closer look...
  • B12 deficiency: A hidden trigger of inflammation?

    10/18/2023 9:34:37 PM PDT · by ConservativeMind · 53 replies
    A new study has identified a compelling link between vitamin B12 deficiency and chronic inflammation, which is associated with a range of health problems including cardiovascular disease, diabetes, and neurodegenerative disorders. The research examined the effects of circulating B12 concentration on the levels of two key inflammatory markers in both humans and mice. Vitamin B12, an essential nutrient with roles in various physiological processes, is known to be critical for overall health. Its deficiency can be the result of dietary insufficiency or inefficient absorption in the body. This can lead to a range of complications, including neurological disorders. While previous...
  • Calorie restriction in humans builds strong muscle and stimulates healthy aging genes: Study

    10/16/2023 7:31:29 PM PDT · by ConservativeMind · 20 replies
    Medical Xpress / National Institutes of Health / Aging Cell ^ | Oct. 13, 2023 | Jayanta Kumar Das et al
    Reducing overall calorie intake may rejuvenate your muscles and activate biological pathways important for good health. Decreasing calories without depriving the body of essential vitamins and minerals, known as calorie restriction, has long been known to delay the progression of age-related diseases in animal models. This study suggests the same biological mechanisms may also apply to humans. Researchers analyzed data from participants in the Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy (CALERIE), a study that examined whether moderate calorie restriction conveys the same health benefits seen in animal studies. During a two-year span, the goal for participants...
  • Neuroscientists Make 'Unexpected' Discovery Over Cause of Childhood Autism

    10/14/2023 8:09:36 AM PDT · by logi_cal869 · 56 replies
    Newsweak via MSN ^ | 10/14/2023 | Pandora Dewan
    Neuroscientists from the University of Maryland have come a step closer to understanding how disorders such as autism and schizophrenia develop in children, opening the door for potential new treatments. Inflammation in the brain during early childhood has been previously linked to autism and schizophrenia. But the mechanisms behind this link have been unclear. Now Maryland researchers have identified how this inflammation can affect human brain cells and their development, offering a potential mechanism for this association. Their results were published on October 12 in the journal Science Translational Medicine. In their research, the team conducted a post-mortem analysis of...
  • Study highlights long-term, low-grade intestinal inflammation after radiotherapy (Dietary fiber may prevent it)

    10/01/2023 10:39:29 AM PDT · by ConservativeMind · 7 replies
    Medical Xpress / University of Gothenburg / eBioMedicine ^ | Sept. 28, 2023 | Sravani Devarakonda et al
    Patients who have undergone pelvic radiotherapy may live with low-grade chronic inflammation of the lower intestine 20 years after the treatment. This has been shown in a study. Radiotherapy is often necessary to cure or slow down a cancer. Even though today's radiotherapies feature a high level of precision, healthy tissue in and around the radiation field is still affected. The mucous membrane of the large intestine is normally protected against contact with bacteria in feces by a thin barrier of mucus. In the current study, researchers have shown that radiotherapy to the pelvic area affects this thin layer of...
  • Yeasts as triggers of altered immune responses in inflammatory bowel disease (Diet could help)

    09/27/2023 7:51:25 PM PDT · by ConservativeMind · 13 replies
    Medical Xpress / Kiel University / Nature Medicine ^ | Sept. 26, 2023 | Frederike Buhse / Gabriela Rios Martini et al
    Chronic bowel inflammation is based on an excessive or misdirected inflammatory reaction. Experts assume that the immune system also reacts incorrectly to microorganisms in the intestine that do not cause an inflammatory immune reaction in a healthy state. Now, researchers have discovered that yeast fungi could play an important role in this. Trillions of microorganisms colonize the human body, especially the intestine. This microbiome consists mainly of viruses and bacteria, but to a lesser extent also of fungi. However, according to current research, this interaction is disturbed in Crohn's disease, a chronic inflammatory bowel disease where the immune cells react...
  • New research adds evidence to the benefits of ginger supplements for treating autoimmune diseases

    09/23/2023 8:42:28 PM PDT · by ConservativeMind · 20 replies
    Medical Xpress / CU Anschutz Medical Campus / JCI Insight ^ | Sept. 22, 2023 | Kristen Demoruelle, MD, Ph.D. et al
    New research has revealed a potentially important role ginger supplements can play in controlling inflammation for people living with autoimmune diseases. The research focused on studying the impact of ginger supplementation on a type of white blood cell called the neutrophil. The study was especially interested in neutrophil extracellular trap (NET) formation, also known as NETosis, and what it may mean for controlling inflammation. The study found ginger consumption by healthy individuals makes their neutrophils more resistant to NETosis. This is important because NETs are microscopic spider web-like structures that propel inflammation and clotting, which contribute to many autoimmune diseases,...
  • Study shows cardamom increases appetite, burns fat

    08/14/2023 10:32:36 PM PDT · by ConservativeMind · 15 replies
    Medical Xpress / Texas A&M University / International Journal of Molecular Sciences ^ | Aug. 11, 2023 | Adam Russell / Claudia Delgadillo-Puga et al
    A study revealed a range of health and dietary benefits of consuming cardamom, including increased appetite, fat loss and inflammation reduction, making the spice a "superfood." Luis Cisneros-Zevallos, Ph.D. said the study shows cardamom could be a healthy dietary choice, and that its consumption can help maintain lean body weight and reduce fat. Cardamom is a popular spice in many parts of the world and the study findings should expand its popularity. The spice has a warm herbal flavor and an aroma that blends eucalyptus, mint and pepper. "Cardamom is a spice little known in the U.S. but very common...
  • Dementia Tied to Fluctuations in Blood Lipids Over Time

    07/08/2023 5:50:51 PM PDT · by nickcarraway · 3 replies
    MEDPAGETODAY ^ | July 5, 2023 | Judy George
    — Variability in total cholesterol, triglyceride levels at age 60 and older raised riskFluctuations in total cholesterol and triglyceride levels in people 60 and older were tied to a higher risk of incident dementia, including Alzheimer's disease, a longitudinal study showed. Over a median follow-up of 12.9 years, participants in the highest quintile of total cholesterol variability versus the lowest quintile had a 19% increased risk of incident Alzheimer's or related dementias (HR 1.19, 95% CI 1.04-1.36, P=0.011), reported Suzette Bielinski, PhD, of the Mayo Clinic in Rochester, Minnesota, and co-authors. Those in the highest quintile of triglycerides variability had...
  • Propolis found to improve immunity, reduce free radicals and attenuate chronic inflammation in HIV patients

    07/01/2023 8:57:19 PM PDT · by ConservativeMind · 12 replies
    Medical Xpress / FAPESP / Biomedicine & Pharmacotherapy ^ | June 27, 2023 | Karen Ingrid Tasca et al
    An article demonstrates the beneficial effects of consuming 500 milligrams (mg) per day of propolis for people living with HIV, the virus that causes AIDS. The authors found that the group given propolis, unlike the group given placebo, displayed a significant reduction in plasma levels of malondialdehyde, a marker of oxidative stress. Total antioxidant capacity increased slightly in the same group, reflecting the direct combating of free radicals. "Although people living with HIV have excellent life expectancy, one of the problems still faced is the question of premature aging," said biologist Karen Ingrid Tasca. This process of premature aging is...
  • Study improves prediction of therapy response in patients with metastatic renal cell carcinoma (Simple C-reactive protein (CRP) and albumin levels provided much more accuracy)

    06/24/2023 6:55:53 PM PDT · by ConservativeMind · 6 replies
    Medical Xpress / Universitätsklinikum Bonn / JAMA Oncology ^ | June 22, 2023 | Inka Väth / Jonas Saal et al
    Dr. Niklas Klümper and Dr. Jonas Saal demonstrated a significant improvement in predicting the response to therapy in metastatic renal cell carcinoma by incorporating the level of inflammation, which was assessed using two straightforward blood parameters, alongside the conventional imaging-based approach. The research group led by Dr. Klümper has now been able to show that the investigation of two inexpensive and widely available inflammatory markers in the blood (C-reactive protein (CRP) and albumin) significantly improves the prediction of therapy response in patients with metastatic renal cell carcinoma, especially in the large group of patients with disease control in the first...
  • New study gives clues on why exercise helps with inflammation (Six to eight weeks of exercise converts cells away from inflammation)

    06/17/2023 7:55:22 AM PDT · by ConservativeMind · 18 replies
    Medical Xpress / York University / American Journal of Physiology-Cell Physiology ^ | June 15, 2023 | Emina Gamulin / Mayoorey Murugathasan et al
    Researchers have long known that moderate exercise has a beneficial impact on the body's response to inflammation, but what's been less understood is why. New research done on a mouse model suggests that the answers may lie at the production level of macrophages—white blood cells responsible for killing off infections, healing injury and otherwise acting as first responders in the body. "Much like if you train your muscles through exercise, we showed that exercise of moderate intensity ended up training the precursors of those macrophages in the bone marrow," says Ali Abdul-Sater. "The way that exercise is doing this is...