Study directly links high insulin levels to pancreatic cancer

Medical Xpress / University of British Columbia / Cell Metabolism ^ | Oct. 31, 2023 | Dr. Anni Zhang et al

[ConservativeMind]

A study reveals a direct link between high insulin levels, common among patients with obesity and type 2 diabetes, and pancreatic cancer.

The study provides the first detailed explanation of why people with obesity and type 2 diabetes are at an increased risk of pancreatic cancer. The research demonstrates that excessive insulin levels overstimulate pancreatic acinar cells, which produce digestive juices. This overstimulation leads to inflammation that converts these cells into precancerous cells.

"Alongside the rapid increase in both obesity and type 2 diabetes, we're seeing an alarming rise in pancreatic cancer rates," said Dr. James Johnson.

"These findings help us understand how this is happening, and highlights the importance of keeping insulin levels within a healthy range."

The study focused on pancreatic ductal adenocarcinoma (PDAC), the most prevalent pancreatic cancer, and one that is highly aggressive with a five-year survival rate of less than 10%. The incidence of pancreatic cancer is on the rise. By 2030, PDAC is expected to become the second leading cause of cancer-related deaths.

While obesity and type 2 diabetes had previously been established as risk factors for pancreatic cancer, the exact mechanisms remained unclear. This new study sheds light on the role of insulin and its receptors in this process.

"We found that hyperinsulinemia directly contributes to pancreatic cancer initiation through insulin receptors in acinar cells," said Dr. Anni Zhang. "The mechanism involves increased production of digestive enzymes, leading to heightened pancreatic inflammation."

While insulin is widely recognized for its role in regulating blood sugar levels, the study underscores its importance in pancreatic acinar cells. The findings show that insulin supports the physiological function of these cells in producing digestive enzymes that break down fat-rich foods, but at high levels, its increased action can inadvertently foster pancreatic inflammation and the development of precancerous cells.

[ConservativeMind]

This seems a bit strange, because carbs increase insulin need—not fats. This says insulin is required to make digestive enzymes to break down fats, encouraging pancreatic cancer.

I think they are improperly ascribing blame to the wrong nutrients, or, perhaps, they are not describing the high carbs actually co-involved with the fats needing enzymes.

[ConservativeMind]

The “Take Charge Of Your Health” Ping List
This high volume ping list is for health articles and studies which describe something you or your doctor, when informed, may be able to immediately implement for your benefit.

Email me to get on either the “Common/Top Issues” (20 - 25% fewer pings) or “Everything” list.

[Extremely Extreme Extremist]

The worst cancer you can get. Might as well plan your funeral arrangements immediately.

[Jonty30]

My mom died at the end of June. She had diabetes and pancreatic cancer. She remained strong, but took a turn for the worst on her second last day.

[BobL]

They simply CANNOT admit that the ‘treatment’ for diabetes, massive amounts of insulin, is killing diabetic patients. And even worse, they will not admit what you say, which is the OBVIOUS at this point - that carbs drive the need for high levels of insulin, NOT FATS.

It’s almost like they’re telling us, the people who do their homework, that yes, you’re correct, cutting down carbs (which basically means eating a lot of meat) is the way to go, but they cannot let the medical community push that out, since the Globalists are pushing to ELIMINATE meat from Western diets.

[ConservativeMind]

Yeah, I had a few conversations with a friend of a friend who had been diagnosed with bad pancreatic cancer.

He and his wife, sadly, were despondent.

[lurk]

I just had a conversation with a pancan researcher. He was insistent on managing inflammation for prevention.

Early detection is key. People with Jewish genes have a statistical risk.

Pancreatic adenocarcinoma remains the unbeatable beast.

[Vermont Lt]

My wife is four years out from her surgery. It is not the death sentence it used to be. If it is caught early and your medical team are not morons…it is treatable.

The problem is the symptoms sneak up on you. If your primary doctor is not familiar with you—if you go to a ‘factory’ provider—they will often dismiss the symptoms. A few simple blood tests can point them in the right direction, which is an escalating process of tests. Those tests become more and more invasive until the tumor is identified.

The other key here is that the pancreas has two main functions. The top produces enzymes used in digestion. The lower part produces insulin. Cancer in the head will spread more easily because of its close connection to the liver and stomach.

Cancer in the tail will mess with your insulin production. This is the type that Steve Jobs and RBG had. If it is caught early it is much more survivable than the cancer of the head. Of course, it requires surgery and chemo. Steve Jobs decided that eating well would cure him. It didn’t.

The five year SEER just broke 10%. It’s still a grim scenario for those diagnosed late. But, that number is double what it was just a few years ago.