As I remember, "Highlander" was pretty low-tech:
Posted on 01/15/2017 7:05:24 AM PST by combat_boots
Treatment increased life spans of prematurely aging rodents
Magazine issue: Vol. 191, No. 1, January 21, 2017, p. 6
Four proteins that can transform adult cells into embryonic-like ones can also turn back the aging clock, a new study in mice suggests.
Partial reprogramming of cells within prematurely aging mice’s bodies extended the rodents’ average life span from 18 weeks to 24 weeks, researchers report December 15 in Cell. Normal mice saw benefits, too: Muscles and pancreas cells healed better in middle-aged mice that got rejuvenation treatments than in mice that did not. The experiment could be evidence that epigenetic marks — chemical tags on DNA and proteins that change with age, experience, disease and environmental exposures — are a driving factor of aging. Some marks accumulate with age while others are lost.
“It’s an inspiring paper,” says Jan van Deursen, a biologist at the Mayo Clinic in Rochester, Minn., who studies diseases of aging. He gives the paper an “A” for sparking imagination, but lower marks for practical applications to human aging because it would involve gene therapy and could be risky. “It’s all cool, but I don’t see that it could ever be applied in medicine,” he says. “We could be terribly wrong. Hopefully we are.” Researchers reset the mice’s aging clock by genetically engineering the animals to make four proteins when the rodents were treated with the antibiotic doxycycline. Those four proteins — Oct4, Sox2, Klf4 and c-Myc — are known as “Yamanaka factors” after Shinya Yamanaka. The Nobel Prize-winning scientist demonstrated in 2006 that the proteins could turn an adult cell into an embryonic-like cell known as an induced pluripotent stem cell, or iPS cell (SN: 11/3/12, p. 13; SN: 7/14/07, p. 29).
(Excerpt) Read more at sciencenews.org ...
Honestly I feel the pain, and sympathise with you.
I read somewhere that leeches work well for that.
Thanks for the advice. I can’t donate blood since I was stationed in Germany in the 80s. I’m on methotrexate for the immune response. Not sure GABA would do much more. I fought taking meds for quite a while, but decided I had to do something. Feeling 20+ years older is no fun, especially when it’s accompanied by severe pain.
As far as I can tell, it was triggered by my last Anthrax series. I’m not an anti-vaxer, but the correlation in my experience is too high to disregard. This was my third series, and reactions have increased with each shot. Of course, Uncle Sam says it’s just coincidence that more GIs get autoimmune diseases at younger ages.
Either way, God has blessed me with a great family and life is good. No use worrying about things I can’t change. I am still able enough—as long as I don’t get too grumpy. ;)
preservatives? Hell, at this age, I need all the preservatives I can get
The pain itself is destructive and shunts tryptophan away from the brain and reduces cerebrovascular service to the occipital and parietal lobes for reduced working memory: indolamine 2,3 dioxygenase.
It is truly wonderful that you are aware of your blessings. Take care to preserve your blessings. Take wheat grass extract to reduce iron if you cannot donate blood. GABA is produced in the beta cells of the pancreas for the purpose of protecting your cartilage from autoimmune attack. You are obviously deficient in GABA.
The pain itself is destructive and shunts tryptophan away from the brain and reduces cerebrovascular service to the occipital and parietal lobes for reduced working memory: indolamine 2,3 dioxygenase.
It is truly wonderful that you are aware of your blessings. Take care to preserve your blessings. Take wheat grass extract to reduce iron if you cannot donate blood. GABA is produced in the beta cells of the pancreas for the purpose of protecting your cartilage from autoimmune attack. You are obviously deficient in GABA.
Ben and Willard will be happy to hear
Plasma taken from young donors seems to contain factors which, when given to the elderly promote better health. Peter Thiel is interested in this treatment which is related to parabiosis.
Mice are not humans.
As I remember, "Highlander" was pretty low-tech:
“I read somewhere that leeches work well for that. “
So does shaving. At least the way I do it.
sounds like you know your stuff.
so I’ll pitch my issues at you.
recently I’ve had pains in my joints but all on my left side. knee wrist and shoulder. It just feels like a constant sprain.
Its there as a low grade pain. If I do nothing the pain subsides—but doesn’t go away. If I do a little it becomes noticeable. If I do more I have to stop my exercise.
I think the pain is rooted in something besides just injury that repairs with time. But I’m not sure what.
Here’s another thing. I have a bad case of tinnitus—that’s got worse over time. I went to an audiologist who said I’d lost hearing in the low frequencies in one ear. I also have tinnitus. Tinnitus and low frequencies hearing loss are markers for meniere’s disease. This not a disease but rather a malfunction of the cilia in the inner ear. Another sign of meniere’s disease is loss of balance. Which I’ve been experiencing lately.
Lastly, after 10 years of taking finasteride -— I went off recently. As the stories about its side effects became too bad. Further it looked like I was experiencing them.
Those are the issues. Do you read anything about supplements you can take to reduce the issues involved in these ailments.
A low (no) risk approach to chronic joint pain, is to systematically nourish collagen over the long term.
Gelatin (Jello) is collagen. Also soups make with the bones and cartilage cooked in (like a chicken carcass in a slow cooker or pressure cooker) can provide a rich source of the nutritional building blocks to rebuild collagen - which is generally a slow process. A diet rich in the building blocks inevitably has an effect over time.
Glucosamine and Chondroitin are often recommended as isolated supplements which support collagen repair.
Kombucha (fermented/cultured tea) provides a rich vegetarian dose of glucosamine and related factors, and has a reputation for relieving joint pain. I drink a pint or two per day, and believe that it has helped my joints a quite a bit over the course of a year (the translucent “mother” that floats in kombucha is the richest part for nourishing collagen - mix it in, or get used to swallowing them).
Stretching with isometric tension (like a cat, or like while yawning, or like Bruce Lee) is particularly suitable for treating chronic joint pain. Not only does in develop freer movement, but you can strengthen while avoiding most of the disabling downside from other forms of exercise, that you described. The emphasis is just reaching very strongly for several seconds in every direction - especially the hard ones, like behind the back.
Also, exercise or stretching in the water is widely regarded for treating chronic joint pain. Best wishes.
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