Posted on 04/27/2024 8:16:39 AM PDT by george76
Despite progress in combating antimicrobial resistance (AMR) in the U.S. since its peak during the COVID-19 pandemic, hospital-acquired AMR infections remain well above pre-pandemic levels, according to a major new study examining AMR before, during, and after the COVID-19 pandemic in 120 US hospitals.
The study was led by Dr. Christina Yek from the US National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH), and is being presented at this year's ESCMID Global Congress (formerly ECCMID) in Barcelona, Spain (27-30 April). It reveals that AMR rates remain high largely due to the persistence of hospital-onset infections, in particular those caused by gram-negative resistant organisms.
These findings highlight the urgent need for action to identify the drivers of and solutions for difficult-to-treat gram-negative AMR.
AMR is estimated to cause at least 35,000 deaths annually in the US and 1.27 million worldwide. In 2022, a US Centers for Disease Control and Prevention report described alarming rises in AMR across US hospitals during the first year of the COVID-19 pandemic, with resistant hospital-related infections growing 15% between 2019 and 2020. However, the key drivers and lasting effects of this phenomenon remain unexplored.
To provide an updated report on the status of AMR in US hospitals, researchers analyzed trends in incidence of AMR infections in adults (aged 18 years and older) in 120 hospitals before (Jan 2018–Dec 2019), during (March 2020–Feb 2022), and after the pandemic (March–Dec 2022), that were continuously reporting in the PINC-AI database—an administrative dataset representing 20% of US hospitalizations.
All hospitalizations were examined for culture-confirmed infection by six pathogens—methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant Enterococcus (VRE), extended-spectrum cephalosporin-resistant Enterobacterales (ECR), carbapenem-resistant Enterobacterales (CRE), Acinetobacter baumannii (CRAB), and Pseudomonas aeruginosa (CR-PA)—acquired either before (community-acquired) or after three days of hospitalization.
During the pandemic, the overall prevalence of AMR infections increased by 6.3% (from 181.9 to 193.3 per 10,000 hospitalizations). This was driven primarily by a steep rise in hospital-acquired resistant infections, which rose at least 32% (from 28.7 to 38.0 per 10,000 hospitalizations), compared with community-acquired infections, which increased just 1.4% (153.2 to 155.3 per 10,000 hospitalizations).
During the pandemic, infections due to gram-negative pathogens—those that are resistant to multiple drugs and are increasingly resistant to most available antibiotics—increased by almost 20% compared to pre-pandemic levels, while resistant gram-positive infections fell by 4.2%.
The greatest increases were seen in hospital-acquired infections resistant to commonly prescribed antibiotics called carbapenems, which are considered the drugs of last resort for treating severe infections. These included infections caused by CRAB which grew 151% during the two years of the pandemic (0.5 to 1.3 per 10,000 hospitalizations), followed by CRE which rose 62% (1.1 to 1.8 per 10,000 hospitalizations), and CR-PA which increased by 54% (2.2 to 3.4 per 10,000 hospitalizations).
In contrast, during and after the pandemic, community-acquired MRSA infections declined by 10% (from 71.1 to 63.7 per 10,000 hospitalizations) and 19% (71.1 to 57.8 per 10,000 hospitalizations), respectively. This decreasing trend, which had preceded the pandemic, may have been further boosted by reduced societal mobility and interactions as a result of pandemic restrictions.
Interestingly, the researchers also found that hospitals with the highest levels of surges in severely ill COVID-19 patients during the pandemic had the largest increases in hospital-acquired AMR infections, with incidence increasing in a stepwise fashion. Larger hospitals with the highest bed capacity (500 beds) had more than double the odds of AMR infections compared to hospitals with the lowest bed capacity (0-99 beds).
"It is likely that surges in severely ill COVID-19 patients during the pandemic corresponded with significant surges in antibiotic use and challenges following infection and prevention control protocols in strained hospitals," says Dr. Yek. "In addition, hospitals may have experienced shortages of personal protective equipment, while treating sicker patients who were more likely to require the use of medical devices like ventilators, which would have added to the spread of antimicrobial-resistant infections."
Post-pandemic, overall AMR incidence has nearly returned to pre-pandemic rates (181.9 to 182.2 per 10,000 hospitalizations). However, hospital-acquired AMR infections remained 13% above pre-pandemic levels in December 2022 (28.7 to 32.3 per 10,000 hospitalizations), largely due to the persistence of gram-negative pathogen infections that are resistant to most available first-line antibiotics.
Between March and December 2022, infections due to hospital-acquired carbapenem-resistant organisms remained at least 35% higher than pre-pandemic levels—CRAB (up 43%), CRE (81% increase), and PR-PA (up 38%).
"While overall antimicrobial resistance levels appear to have almost returned to pre-pandemic levels, the persistence of high rates of hospital-acquired AMR infections in US health care facilities is concerning. More action is needed to protect people, especially from difficult-to-treat hospital-acquired gram-negative infections that remain concerningly high," says Dr. Yek.
yek..is that Irish?
Aside from not using antibiotics for viral infections that do not have a bacterial component, I’m not sure what we can do to decrease the spread of antibiotic resistant infections.
I recently lost a cat to an antibiotic resistant infection. These things are nasty.
Is there anyone here on low dose doxy who has developed the Super bug issue? Doxy is very effective for me in reducing mmp9 but I am worried about developing resistance. I am thinking about doing cycles of it for a reset.
Key sentences: “It is likely that surges in severely ill COVID-19 patients during the pandemic corresponded with significant surges in antibiotic use and challenges following infection and prevention control protocols in strained hospitals,” says Dr. Yek. “In addition, hospitals may have experienced shortages of personal protective equipment, while treating sicker patients who were more likely to require the use of medical devices like ventilators, which would have added to the spread of antimicrobial-resistant infections.”
Stay away from hospitals
Stay away from “boo$ter$” which weaken the immune system.
”Despite progress in combating antimicrobial resistance (AMR) in the U.S. since its peak during the COVID-19 pandemic,
hospital-acquired AMR infections remain well above pre-pandemic levels, according to a major new study examining AMR before, during, and after the COVID-19 pandemic in 120 US hospitals. “
”The study was led by Dr. Christina Yek from the US National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health (NIH),
and is being presented at this year's ESCMID Global Congress (formerly ECCMID) in Barcelona, Spain (27-30 April).
It reveals that AMR rates remain high largely due to the persistence of hospital-onset infections,
in particular those caused by gram-negative resistant organisms.”
”These findings highlight the urgent need for action to identify the drivers of and solutions for difficult-to-treat gram-negative AMR. “
”AMR is estimated to cause at least 35,000 deaths annually in the US and 1.27 million worldwide.
In 2022, a US Centers for Disease Control and Prevention report described alarming rises in AMR across US hospitals during the first year of the COVID-19 pandemic,
with resistant hospital-related infections growing 15% between 2019 and 2020. However, the key drivers and lasting effects of this phenomenon remain unexplored…”
”The greatest increases were seen in hospital-acquired infections resistant to commonly prescribed antibiotics
called carbapenems, which are considered the drugs of last resort for treating severe infections. (Emphasis Mine)
These included infections caused by CRAB which grew 151% during the two years of the pandemic (0.5 to 1.3 per 10,000 hospitalizations),
followed by CRE which rose 62% (1.1 to 1.8 per 10,000 hospitalizations), and CR-PA which increased by 54% (2.2 to 3.4 per 10,000 hospitalizations). “
”In contrast, during and after the pandemic, community-acquired MRSA infections declined by 10% (from 71.1 to 63.7 per 10,000 hospitalizations)
and 19% (71.1 to 57.8 per 10,000 hospitalizations), respectively.
This decreasing trend, which had preceded the pandemic, may have been further boosted by reduced societal mobility
and interactions as a result of pandemic restrictions. “
”Interestingly, the researchers also found that hospitals with the highest levels of surges in severely ill COVID-19 patients during the pandemic
had the largest increases in hospital-acquired AMR infections, with incidence increasing in a stepwise fashion.
Larger hospitals with the highest bed capacity (500 beds) had more than double the odds of AMR infections compared to hospitals with the lowest bed capacity (0-99 beds).
(the article continues)
“The greatest increases were seen in hospital-acquired infections resistant to commonly prescribed antibiotics called carbapenems”
I am curious to find out if the increase was mainly affecting patients on ventilators.
Thirty some years ago, when my kids were babies, every time they got a cold, they were on antibiotics *just in case*.
Not knowing any better I gave it to them. The oldest got the most and she has the most health issues. By the time my second came along, the antibiotic resistance was starting to become an issue and they were starting to cut back on it. Also, as I became more aware of the risks, I started refusing to take them for every little thing and giving them antibiotics as much.
I sure regret that decision now but it can’t be undone.
Thirty some years ago, when my kids were babies, every time they got a cold, they were on antibiotics *just in case*.
Not knowing any better I gave it to them. The oldest got the most and she has the most health issues. By the time my second came along, the antibiotic resistance was starting to become an issue and they were starting to cut back on it. Also, as I became more aware of the risks, I started refusing to take them for every little thing and giving them antibiotics as much.
I sure regret that decision now but it can’t be undone.
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