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Human lincRNA Genes Contradict Evolution
Institute for Creation Research ^ | 2-26-14 | Jeffrey Tomkins PhD

Posted on 02/26/2014 9:14:56 AM PST by fishtank

Human lincRNA Genes Contradict Evolution by Jeffrey Tomkins, Ph.D. *

Researchers from MIT and the University of Massachusetts Medical School recently characterized a group of genes in humans and other mammals that not only defies evolutionary models but vindicates the Bible’s prediction of the uniqueness of created kinds with distinct genetic features.1

Even though less than five percent of the human genome codes for protein, scientists have discovered that our genome is pervasively transcribed (expressed) in an amazing array of RNA molecules.2,3 And the transcribed regions of the genome located outside the protein-coding areas encode many unique types of genes that produce RNAs used directly by the cell. An important category of these RNAs is the “long intergenic non-coding RNAs” or lincRNAs that have the same type of control structures and features as protein-coding genes.

It is now known that lincRNA genes are critical to cell function, with some even being completely lethal when experimentally disabled in mice.4,5 Because scientists have known for several years that lincRNA genes are more specific to different kinds of creatures than protein-coding genes, they have begun to use them to test evolutionary predictions.6

Publishing in the journal Genome Research, the team examined the expression of 1,898 different lincRNA genes in different types of tissues in humans, chimps, macaques, cows, mice, and rats.1 Amazingly, only 80 percent of the human lincRNA genes had counterparts expressed in chimp tissue and only 63 percent were expressed in macaque tissue. These differences are completely outside the evolutionary paradigm and popular rhetoric that claim the human and chimpanzee genomes are nearly identical.

Interestingly, this newly reported research parallels a study recently completed by this author using three different lincRNA data sets. These represent over 50,000 different regions of the human genome, and their sequence was compared to the chimp genome (data not yet published).6 Depending on the data set, all known human lincRNA regions of the genome were found to be only 67 percent to 79 percent similar in their DNA sequence compared to the chimp genome. These findings correlate closely with the lincRNA gene expression results in Genome Research.1

Over 20 percent of human lincRNAs are dissimilar between humans and chimps and therefore have no evolutionary history—they appear suddenly and fully functional in the human genome. While the evolutionary model once again fails to predict this incredible genetic discontinuity, the creation model accurately forecasts that all creatures are uniquely created after their kind, a prediction evident in the structure and function of the human genome.

References:

Washietl, S., M. Kellis, and M. Garber. Evolutionary dynamics and tissue specificity of human long noncoding RNAs in six mammals. Genome Research. Posted on genome.cshlp.org January 15, 2014, accessed February 15, 2014.

Clark, M. B. et al. 2013. The dark matter rises: the expanding world of regulatory RNAs. Essays in Biochemistry. 54 (1): 1-16.

Hangauer, M. J., I. W. Vaughn, and M. T. McManus. 2013. Pervasive Transcription of the Human Genome Produces Thousands of Previously Unidentified Long Intergenic Noncoding RNAs. PLoS Genetics. 9 (6): e1003569.

Sauvageau, M. et al. 2013. Multiple knockout mouse models reveal lincRNAs are required for life and brain development. eLife. 2: e01749.

Tomkins, J. 2014. Mouse Study Shows “Junk DNA” Is Actually Required. Creation Science Update. Posted on icr.org January 15, 2014, accessed February 15, 2014.

Tomkins, J. 2014. Using ENCODE Data for Human-Chimp DNA Comparisons. Acts & Facts. 43 (1): 9.

* Dr. Tomkins is Research Associate at the Institute for Creation Research and received his Ph.D. in genetics from Clemson University.

Article posted on February 26, 2014.


TOPICS: News/Current Events
KEYWORDS: creation; lincrna
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Washietl, S., M. Kellis, and M. Garber. Evolutionary dynamics and tissue specificity of human long noncoding RNAs in six mammals. Genome Research. Posted on genome.cshlp.org January 15, 2014, accessed February 15, 2014.

http://genome.cshlp.org/content/early/2014/01/15/gr.165035.113.long

1 posted on 02/26/2014 9:14:56 AM PST by fishtank
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To: fishtank

Everything contradicts evolution, but does that mean the demonic idiots are going to give up?
.


2 posted on 02/26/2014 9:18:08 AM PST by editor-surveyor (Freepers: Not as smart as I'd hoped they'd be)
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To: metmom

Ping!


3 posted on 02/26/2014 9:18:45 AM PST by editor-surveyor (Freepers: Not as smart as I'd hoped they'd be)
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To: fishtank

“Over 20 percent of human lincRNAs are dissimilar between humans and chimps and therefore have no evolutionary history—they appear suddenly and fully functional in the human genome. While the evolutionary model once again fails to predict this incredible genetic discontinuity, the creation model accurately forecasts that all creatures are uniquely created after their kind, a prediction evident in the structure and function of the human genome.”

which is why the advocates for evolution insist that the “evolutionary” links, between humans and chimps, is in homanoid species that no longer exist and for which there is no available DNA/RNA samples


4 posted on 02/26/2014 9:21:23 AM PST by Wuli
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To: Wuli

I guess that 20 percent trumps the other 80 percent.


5 posted on 02/26/2014 9:25:12 AM PST by tacticalogic
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To: editor-surveyor
No. They would rather believe a person who could not walk 100 yards on a lava field to notice that there were other specialty feeders there.
6 posted on 02/26/2014 9:27:13 AM PST by Domangart (LBGT = NAMBLA)
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To: fishtank

Science has been unable to explain the really big ones: the origin of the universe, the beginning of life, and the beginning of homo sapiens.


7 posted on 02/26/2014 9:30:58 AM PST by I want the USA back (Media: completely irresponsible traitors. Complicit in the destruction of our country.)
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To: FReepers

Donate!

8 posted on 02/26/2014 9:33:41 AM PST by DJ MacWoW (The Fed Gov is not one ring to rule them all)
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To: editor-surveyor

> Everything contradicts evolution

Everthing contradicts “Gobal Warmism”, too, but that doesn’t stop them, either.

Evolution and Global Warming are the ugly twin-sisters of modern pseudo-science.


9 posted on 02/26/2014 9:38:34 AM PST by Westbrook (Children do not divide your love, they multiply it.)
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To: fishtank

It doesn’t look like any commenters understand the article. They’d rather take potshots at science they don’t understand.


10 posted on 02/26/2014 9:39:59 AM PST by Moonman62 (The US has become a government with a country, rather than a country with a government.)
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To: fishtank

“they appear suddenly and fully functional in the human genome....

But... were to believe that some CHIMPS thought....of these genes all by themselves/

I just looked on one of my hard drives this morning and noticed a brand new book my computer wrote last..night....


11 posted on 02/26/2014 9:42:41 AM PST by MeshugeMikey (how many times has obie fundamentaly transformed obamacare now?)
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To: MeshugeMikey

I just looked on one of my hard drives this morning and noticed a brand new book my computer wrote last..night..


Not surprising since you have all the tools and components required. You have the letters, words, spell check, grammar check and formats to follow.

Just because we can’t actually make sense of the prose, doesn’t mean it is senseless.

A thousand monkeys on a thousand typewriters for a thousand years may be channeling their ancient alien. Just because our limited human understanding of language can’t figure it out, just shows how primitive we are./s


12 posted on 02/26/2014 9:54:24 AM PST by Zeneta (Thoughts in time and out of season.)
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To: Zeneta
Its amazing there was even an Illustration on the cover!


13 posted on 02/26/2014 9:59:23 AM PST by MeshugeMikey (how many times has obie fundamentaly transformed obamacare now?)
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To: fishtank

Liberal Darwinists will go the great lengths to make a monkey of themselves.


14 posted on 02/26/2014 9:59:38 AM PST by Beagle8U (Unions are an Affirmative Action program for Slackers! .)
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To: MeshugeMikey

The list of “dedications” must look like Bill Clinton’s Rolodex.


15 posted on 02/26/2014 10:04:15 AM PST by Zeneta (Thoughts in time and out of season.)
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To: Beagle8U

Liberal Darwinists will go the great lengths to make a monkey of themselves


Interestingly enough.

They taught Chimps sign language in an effort to shrink the gap between humans. They actually learned sign language.

And just like the Liberal Darwinist, the chimps had nothing interesting to say.


16 posted on 02/26/2014 10:08:53 AM PST by Zeneta (Thoughts in time and out of season.)
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To: fishtank

This ICR has a good ability to comment in forefront biological research and I appreciate hearing of new research in these posts of their commentaries.

As for this:

“...the Bible’s prediction of the uniqueness of created kinds with distinct genetic features.”

I’m not sure I buy the premise that this is “predicted” in the Bible.

More interestingly, though, the idea of genetic uniqueness in species was actually one of the basic predictions of evolutionary theory in the Modern Synthesis of the early 1900’s.

The discoveries that in fact genes were ancient and conserved among species didn’t support Modern Synthesis assumptions.


17 posted on 02/26/2014 10:51:33 AM PST by ifinnegan
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To: Moonman62

“It doesn’t look like any commenters understand the article. They’d rather take potshots at science they don’t understand.”

Can you talk a bit about what they don’t understand?

That would seem to be helpful.


18 posted on 02/26/2014 10:53:24 AM PST by ifinnegan
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To: ifinnegan
The author is conflating the entire genome, and what's been said about it in the media, with these lincRNA coding regions inside the genomes.
These differences are completely outside the evolutionary paradigm and popular rhetoric that claim the human and chimpanzee genomes are nearly identical.

19 posted on 02/26/2014 11:06:20 AM PST by Moonman62 (The US has become a government with a country, rather than a country with a government.)
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To: Moonman62

I love the “monkey” jokes. Eagerly trotted out as if no one ever told it before.


20 posted on 02/26/2014 11:53:27 AM PST by DManA
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