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How Exercise Changes Fat and Muscle Cells
NY Times ^ | July 31, 2013 | GRETCHEN REYNOLDS

Posted on 07/31/2013 10:02:54 PM PDT by neverdem

Exercise promotes health, reducing most people’s risks of developing diabetes and growing obese. But just how, at a cellular level, exercise performs this beneficial magic — what physiological steps are involved and in what order — remains mysterious to a surprising degree.

Several striking new studies, however, provide some clarity by showing that exercise seems able to drastically alter how genes operate.

Genes are, of course, not static. They turn on or off, depending on what biochemical signals they receive from elsewhere in the body. When they are turned on, genes express various proteins that, in turn, prompt a range of physiological actions in the body.

One powerful means of affecting gene activity involves a process called methylation, in which methyl groups, a cluster of carbon and hydrogen atoms, attach to the outside of a gene and make it easier or harder for that gene to receive and respond to messages from the body. In this way, the behavior of the gene is changed, but not the fundamental structure of the gene itself. Remarkably, these methylation patterns can be passed on to offspring – a phenomenon known as epigenetics.

What is particularly fascinating about the methylation process is that it seems to be driven largely by how you live your life. Many recent studies have found that diet, for instance, notably affects the methylation of genes, and scientists working in this area suspect that differing genetic methylation patterns resulting from differing diets may partly determine whether someone develops diabetes and other metabolic diseases.

But the role of physical activity in gene methylation has been poorly understood, even though exercise, like diet, greatly changes the body. So several groups of scientists recently set out to determine what working out does to the exterior of our genes.

The answer, their recently published...

(Excerpt) Read more at well.blogs.nytimes.com ...


TOPICS: Culture/Society; News/Current Events
KEYWORDS: epigenetics; exercise; exercisephysiology; health; obesity; type2diabetes
A six months exercise intervention influences the genome-wide DNA methylation pattern in human adipose tissue.

Acute exercise remodels promoter methylation in human skeletal muscle.

1 posted on 07/31/2013 10:02:55 PM PDT by neverdem
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To: neverdem

Pretty darned interesting, Neverdem. I better start exercising again.


2 posted on 07/31/2013 11:01:52 PM PDT by JT Hatter (Who is Barack Obama? And What is He Really Up To?)
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To: neverdem

Great article. It looks like life itself depends upon our exercise. This is terrific information and totally consistent with what I have been teaching for years as a diabetes educator. Now, if people would just believe it and act on it!


3 posted on 07/31/2013 11:06:41 PM PDT by Bravada (Wherever I Stand, I Stand With Israel!)
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To: uncitizen

Bkmk


4 posted on 07/31/2013 11:14:22 PM PDT by uncitizen (Barack Obama hates white people)
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To: Bravada

I’ve been told that death stalks at around 2.5 mph. If you can walk at least that fast, you’ll stay ahead of him.


5 posted on 07/31/2013 11:26:16 PM PDT by Jonty30 (What Islam and secularism have in common is that they are both death cults)
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To: neverdem

Excellent!

I would add, have the burger, but not the fries.

BTTT


6 posted on 07/31/2013 11:40:31 PM PDT by dixiechick2000 (To the GOPe ~ I'm now a proud member of the Wacko Bird party.)
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To: Jonty30
I’ve been told that death stalks at around 2.5 mph. If you can walk at least that fast, you’ll stay ahead of him.

It's interesting that you perceive death as a male. I'm used to taking it for a female.

Top pictures from the Google

7 posted on 07/31/2013 11:41:30 PM PDT by Freelance Warrior (A Russian.)
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To: Freelance Warrior
Hey! Death gots' a hoodie on!

That be racisss...........

8 posted on 07/31/2013 11:47:27 PM PDT by doorgunner69
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To: neverdem

I like to do yoga.
You put your arm or leg in the air and hold it there.
Screw that tiring bend it back and forth stuff.


9 posted on 07/31/2013 11:55:14 PM PDT by Berlin_Freeper
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To: Freelance Warrior

So does Marvel Comics. Just ask Thanos . . .


10 posted on 08/01/2013 12:08:09 AM PDT by Olog-hai
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To: neverdem

Smoking is an exercise, too ya know


11 posted on 08/01/2013 12:18:11 AM PDT by max americana (fired liberals in our company after the election, & laughed while they cried (true story))
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To: neverdem

great. thanks for posting.


12 posted on 08/01/2013 12:52:52 AM PDT by GOP Poet
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bookmark


13 posted on 08/01/2013 1:26:28 AM PDT by freds6girlies (many that are first shall be last; and the last shall be first. Mt. 19:30. R.I.P. G & J)
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To: neverdem

This article and study are obviously part of a conspiracy from the health and fitness lobby trying to trick people into buying their products. Just go back inside and sit down and don’t buy the hype. Look at all the great people who don’t exercise at all. Buddha. Jabba the Hutt. Michael Moore... errr, uh, wait.


14 posted on 08/01/2013 1:31:26 AM PDT by Greetings_Puny_Humans
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To: neverdem

15 posted on 08/01/2013 1:38:13 AM PDT by JoeProBono (Mille vocibus imago valet;-{)
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To: Jonty30

16 posted on 08/01/2013 1:41:10 AM PDT by JoeProBono (Mille vocibus imago valet;-{)
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To: Wage Slave

Wanna read later....muy interesante.


17 posted on 08/01/2013 4:01:32 AM PDT by Wage Slave
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To: neverdem

Bump.


18 posted on 08/01/2013 4:12:06 AM PDT by gov_bean_ counter (Romans 1:22 Professing themselves to be wise, they became fools,)
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To: neverdem

I just started body for life this week... I am dying.

Wifey is doing it with me, although she doesn’t have far to go... I married well!


19 posted on 08/01/2013 5:06:20 AM PDT by WomBom ("I read Free Republic for the pictures")
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To: neverdem

This is from the New York times. There’s likely not a word in it that’s true.


20 posted on 08/01/2013 5:19:36 AM PDT by IronJack (=)
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To: Berlin_Freeper

try doing some of the poses while holding weights. I think it’s called power yoga but i’m not sure. I tried some from an article in Prevention. Yow, you can really be sore the next day!


21 posted on 08/01/2013 5:56:06 AM PDT by midnightcat
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To: neverdem

M4L


22 posted on 08/01/2013 6:28:42 AM PDT by Scrambler Bob ( Concerning bo -- that refers to the president. If I capitalize it, I mean the dog.)
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To: Jonty30; Bravada
I’ve been told that death stalks at around 2.5 mph. If you can walk at least that fast, you’ll stay ahead of him.

So, does that mean I have to walk more than 60 miles a day to stay ahead of her?

23 posted on 08/01/2013 7:05:23 AM PDT by rmh47 (Go Kats! - Got eight? NRA Life Member])
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To: midnightcat

Thanks for the tip.


24 posted on 08/01/2013 7:44:50 AM PDT by Berlin_Freeper
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To: rmh47

No. It means that you have to be able to walk that fast or faster.


25 posted on 08/01/2013 10:07:19 AM PDT by Jonty30 (What Islam and secularism have in common is that they are both death cults)
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To: Bravada; austinmark; FreedomCalls; IslandJeff; JRochelle; MarMema; Txsleuth; Newtoidaho; ...
This is terrific information and totally consistent with what I have been teaching for years as a diabetes educator.

Bravada, what did you do before you became a diabetes educator, if I may ask?

Diabetes drug metformin proves useful for other problems

FReepmail me if you want on or off the diabetes ping list.

26 posted on 08/01/2013 12:22:45 PM PDT by neverdem (Register pressure cookers! /s)
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To: Bravada
My uncle goes for a quick run after every meal. His reason is "we were made to move!"

He is in his seventies and moves like a much younger man.

27 posted on 08/01/2013 12:28:25 PM PDT by Harmless Teddy Bear (Revenge is a dish best served with pinto beans and muffins)
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To: neverdem

^


28 posted on 08/01/2013 12:30:11 PM PDT by BunnySlippers (I LOVE BULL MARKETS . . .)
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To: Jonty30

Didn’t help Jim Fixx.


29 posted on 08/01/2013 12:38:28 PM PDT by antidisestablishment (Mahound delenda est)
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To: neverdem

The past several months have been cold and wet. I did not get into my exercise routine.

My A1c had crept over 7 as a result of the 9 months of relative sedentary activity, perhaps too many carbs and age. All have an effect. I began metformin and began to test fasting blood sugar most mornings.

The 500 mg prescribed metformin seemed to have no or minimal effect.

As soon as I began paddling my kayak for 2 hours, twice a week, an riding my bike some on the other days, the numbers went down. At 71 I doubt I can ever return to low 6 A1c but , 7 is my goal.

Exercise unquestionably makes a difference in my numbers.


30 posted on 08/01/2013 12:50:23 PM PDT by bert ((K.E. N.P. N.C. +12 ..... Travon... Felony assault and battery hate crime)
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To: bert
My A1c had crept over 7 as a result of the 9 months of relative sedentary activity

First, I am not diabetic, though I clearly was on the path. I had all the symptoms of metabolic syndrome - obesity, hypertension, acid reflux, sleep apnea, back pain, acanthosis nigricans, etc. My fasting blood sugar was 105, by A1C was 5.8. My OGTT peaked at 177, with levels still elevated after two hours.

After a year of low-carb, combined with weight lifting, I've lost 80 pounds, all my various ailments are gone. My blood pressure is down from 140/100, with meds, to 110/70 without. My dawn phenomenon blood sugar is 83, it's in the mid-70's throughout the day. My latest OGTT peaked at 114, and was back to normal within an hour.

And my A1C is 4.9.

Bernstein makes a convincing argument that numbers in that range should be our goal. And I believe they are achievable for most, though it will take more effort for some than for others.

31 posted on 08/01/2013 1:38:16 PM PDT by jdege
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To: neverdem

bump for later


32 posted on 08/01/2013 3:25:55 PM PDT by RightField (one of the obstreperous citizens insisting on incorrect thinking - C. Krauthamer)
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To: Bravada

I always laugh when the commercials say “if diet and exercise doesn’t work”....If done correctly diet and exercise always works!


33 posted on 08/01/2013 3:34:21 PM PDT by Blackirish (Forward Comrades!!!!!!!!!)
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To: antidisestablishment
Didn’t help Jim Fixx.

***********************

LOL! I was thinking the same thing!

34 posted on 08/01/2013 3:37:11 PM PDT by trisham (Zen is not easy. It takes effort to attain nothingness. And then what do you have? Bupkis.)
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