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Keyword: type2diabetes

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  • Saturated Fat and Skepticism

    05/07/2014 2:40:30 PM PDT · by neverdem · 23 replies
    National Review Online ^ | May 2014 | Mona Charen
    The scientific community is not immune to politics, bias, and self-interest.The headline looks like a hoax saturated fat does not cause heart disease but its real. This news is more than just another example of changing health guidelines. Its a cautionary tale about trusting the scientific consensus. For more than 50 years, the best scientific minds in America assured us that saturated fat was the enemy. Animal fat, we were instructed, was the chief culprit in causing obesity, Type II diabetes, and heart disease. Throughout my adult life, I have conscientiously followed the guidelines dispensed by the health...
  • Obesity is Inflammatory Disease, Rat Study Shows

    05/01/2014 3:12:41 PM PDT · by neverdem · 22 replies
    Sci-News.com ^ | Dec 5, 2013 | NA
    Scientists led by Dr David Fairlie from the University of Queensland, Australia, have found abnormal amounts of an inflammatory protein called PAR2 in the fat tissues of overweight and obese rats and humans. PAR2 is also increased on the surfaces of human immune cells by common fatty acids in the diet. When obese rats on a diet high in sugar and fat were given a new oral drug that binds to PAR2, the inflammation-causing properties of this protein were blocked, as were other effects of the high-fat and high-sugar diet, including obesity itself.Zucker Rat, a pet rat that has developed...
  • Low-carb ketogenic diet takes on low-fat diet for diabetes: Undisputed winner

    04/24/2014 4:28:55 PM PDT · by neverdem · 54 replies
    Examiner ^ | April 23, 2014 | Samantha Chang
    Low-carb, high-fat diets outperformed low-fat diets for managing and even reversing type 2 diabetes, Diabetes.co.uk reported. According to an eight-year study conducted by the Second University of Naples, men and women who followed the low-carb, higher-fat Mediterranean diet were able to come off their diabetes drugs and reverse their diabetes symptoms more readily than people who followed a low-fat diet.In the study, two groups of diabetic men and women were instructed to either follow a low-fat diet or a low-carb, high-fat Mediterranean diet that was comprised of at least 30% fat.The results showed that the higher-fat, low-carb dieters were able...
  • Diabetes Complication Rates Drop Among U.S. Adults

    04/24/2014 3:40:44 PM PDT · by neverdem · 6 replies
    HealthDay News via Philadelphia Inquirer ^ | April 16, 2014 | Serena Gordon
    The rates of five serious complications from diabetes -- heart disease, stroke, kidney disease, amputations and death -- have all dropped dramatically since 1990, a new U.S. government study shows. Heart attack rates have decreased nearly 70 percent in people with diabetes. Stroke rates have dropped by more than 50 percent, as have lower extremity amputations. Deaths from high blood sugar crises have fallen nearly 65 percent, and the risk of end-stage kidney disease is down 28 percent, according to the study. The biggest declines in diabetes-related complications have occurred for heart attack and stroke, especially among people aged 75...
  • Indian scientist develops potential non-insulin diabetes drug

    04/03/2014 7:56:42 PM PDT · by Pining_4_TX · 22 replies
    The Financial Express ^ | 04/02/14 | The Financial Express (doesn't say)
    "We find that there is a peptide hormone in the gut called GLP1 that increases the secretion of insulin only when the blood glucose is high. This effectively eliminates the risk of hypoglycemic shock. Another advantage is that GLP1 administration has been found to stimulate weight-loss. The hormone offers the promise of revolutionising the treatment of Type II diabetes and reduce obesity," he said.
  • Mutation Kills Off Gene Responsible For Type 2 Diabetes

    03/03/2014 8:09:37 AM PST · by BenLurkin · 9 replies
    counselheal.com ^ | Mar 03, 2014 10:20 AM EST | Kamal Nayan
    The research might lead to the development of a drug that could mimic the protective effect of these mutations. Researchers believed the results could open new ways of preventing this devastating disease.
  • Could Alzheimers be Type 2 diabetes? Scientists claim extra insulin produced by those

    12/01/2013 8:34:08 PM PST · by Olog-hai · 20 replies
    Mail on Sunday (UK) ^ | 17:36 EST, 1 December 2013 | Lizzie Edmonds and Sophie Borland
    Alzheimers and diabetes may be the same disease, scientists claim. They have uncovered evidence that the debilitating form of dementia may be late stages of type 2 diabetes. The discovery would explain why nearly three quarters of patients with this form of diabetes go on to develop Alzheimers. Researchers from Albany University, New York State, believe the excess insulin they produce gets into the brain and disrupts key chemicals. Eventually masses of amyloid proteinswhich poison brain cellsare created because of the excess which leads to Alzheimers, they say.
  • News In Brief: Fructose may be key to weight gain

    09/10/2013 12:44:32 PM PDT · by Red Badger · 54 replies
    www.sciencenews.org ^ | September 9, 2013 | By Nathan Seppa
    Mice that could not make or metabolize the sugar gained less than normal mice. Mice lacking the ability to metabolize fructose dont gain nearly as much weight as normal mice do, researchers report September 10 in Nature Communications. Fructose, which some people blame for the obesity epidemic and its related health crises (SN: 6/1/13, p. 22), shows up in high-fructose corn syrup and in table sugar, or sucrose. The body also makes home-grown fructose by modifying glucose in a process involving an enzyme called aldose reductase.
  • Americans cut back on Soda - Coca-Cola, PepsiCo and Dr. Pepper Snapple Group see continued sales...

    07/27/2013 1:38:23 PM PDT · by neverdem · 99 replies
    NY Daily News ^ | July 26, 2013 | ASSOCIATED PRESS
    It seems that not even Beyonce or new, lower-calorie options can convince Americans to drink more soda. Coca-Cola Co., PepsiCo Inc. and Dr Pepper Snapple Group Inc. all sold less soda in the second quarter in North America, dashing hopes for the moment that splashy new marketing and different sweetener mixes could get drinkers back. Coca-Cola Co. said it sold 4 percent less soda in North America, while PepsiCo Inc. simply said its decline for the region was in the "mid-single digits." Dr Pepper sold 3 percent less of the fizzy drinks...
  • Researchers Link Obesity and the Body's Production of Fructose

    09/11/2013 3:10:21 PM PDT · by neverdem · 18 replies
    ScienceDaily ^ | Sep. 10, 2013 | NA
    Researchers at the University of Colorado School of Medicine reported today that the cause of obesity and insulin resistance may be tied to the fructose your body makes in addition to the fructose you eat. In recent years the role of added sweeteners, such as high fructose corn syrup and table sugar (sucrose), has taken center stage as risk factors for obesity and insulin resistance. Numerous studies suggest that the risk from added sugars may be due to the fructose content. But in the study published in the Sept. 10 edition of Nature Communications, the team led by researchers at...
  • To Ward Off Diabetes, Eat Whole Fruit, Shun Fruit Juice

    09/06/2013 1:21:33 PM PDT · by neverdem · 25 replies
    National Geographic ^ | September 5, 2013 | Amanda Fiegl
    Blueberries, grapes, and apples offer the strongest health benefits.Science is finding more health benefits from blueberriesbut raising more concerns about fruit juice. According to a new study by Harvard University researchers, eating whole fruits helps ward off diabetes, while drinking juice can actually raise the risk of developing the disease.In a study published in the British Medical Journal, nutrition experts report that consumption of certain fruitsespecially blueberriescut peoples risk of type 2 diabetes by as much as 26 percent in a survey of more than 180,000 subjects over two and a half decades.Study participants were asked about their consumption of...
  • Key Protein Accelerates Diabetes in Two Ways

    08/28/2013 1:27:20 PM PDT · by neverdem · 20 replies
    ScienceDaily ^ | Aug. 25, 2013 | NA
    The same protein tells beta cells in the pancreas to stop making insulin and then to self-destruct as diabetes worsens, according to a University of Alabama at Birmingham (UAB) study published online today in the journal Nature Medicine. Specifically, the research revealed that a protein called TXNIP controls the ability of beta cells to make insulin, the hormone that regulates blood-sugar levels. "We spent years confirming that TXNIP drives beta-cell death in both Type 1 and Type 2 diabetes," said Anath Shalev, M.D., director of the UAB Comprehensive Diabetes Center and senior author of the paper. "We were astounded to...
  • Endocannabinoids trigger inflammation that leads to diabetes

    08/21/2013 5:39:52 PM PDT · by neverdem · 9 replies
    National Institutes of Health ^ | August 19, 2013 | NA
    NIH scientists identify possible treatment target for type 2 diabetesResearchers at the National Institutes of Health have clarified in rodent and test tube experiments the role that inflammation plays in type 2 diabetes, and revealed a possible molecular target for treating the disease. The researchers say some natural messenger chemicals in the body are involved in an inflammatory chain that can kill cells in the pancreas, which produces insulin. A report of the finding appears online in Nature Medicine.“This study is a significant milestone in an ongoing exploration of the endocannabinoid system’s role in the metabolic complications of obesity,” says...
  • Diabetes drug metformin proves useful for other problems

    08/01/2013 12:03:23 PM PDT · by neverdem · 29 replies
    USA TODAY | July 30, 2013 | Karen Weintraub
    Here's the link.
  • How Exercise Changes Fat and Muscle Cells

    07/31/2013 10:02:54 PM PDT · by neverdem · 33 replies
    NY Times ^ | July 31, 2013 | GRETCHEN REYNOLDS
    Exercise promotes health, reducing most peoples risks of developing diabetes and growing obese. But just how, at a cellular level, exercise performs this beneficial magic what physiological steps are involved and in what order remains mysterious to a surprising degree. Several striking new studies, however, provide some clarity by showing that exercise seems able to drastically alter how genes operate. Genes are, of course, not static. They turn on or off, depending on what biochemical signals they receive from elsewhere in the body. When they are turned on, genes express various proteins that, in turn, prompt a range...
  • Gastric bypass makes gut burn sugar faster

    07/28/2013 11:38:54 AM PDT · by neverdem · 21 replies
    Nature News ^ | 25 July 2013 | Heidi Ledford
    Diabetic rats control blood glucose better after weight-loss surgery. A procedure increasingly used to treat obesity by reducing the size of the stomach also reprogrammes the intestines, making them burn sugar faster, a study in diabetic and obese rats has shown. If the results, published today in Science1, hold true in humans, they could explain how gastric bypass surgery improves sugar control in people with diabetes. They could also lead to less invasive ways to produce the same effects. This opens up the idea that we could take the most effective therapy we have for obesity and diabetes and come...
  • Diet Sodas, Other Products with Artificial Sweeteners Do Not Help with Weight Loss

    07/15/2013 4:18:18 PM PDT · by neverdem · 26 replies
    Nature World News ^ | Jul 12, 2013 | Affirunisa Kankudti
    Diet sodas and other artificially sweetened products don't help with weight loss, according to a new study from Purdue University. According to Susan E. Swithers, a professor of psychological sciences and a behavioral neuro scientist, it is important to know the effects of having too much artificial sweetener in the diet. She added that consuming too much food containing "no-calorie sweeteners" have been known to be associated with increased risk of heart problems and weight gain.About 30 percent of all adults in the U.S. consume artificial sweeteners. Even though, diet sodas have been considered healthy food by many, studies show...
  • Fructose risk factor for metabolic syndrome, diabetes mellitus, and hypertension

    06/26/2013 12:02:26 AM PDT · by neverdem · 60 replies
    FOODCONSUMER ^ | 06/25/2013 | David Liu, PHD
    Tuesday June 25, 2013 (foodconsumer.org) -- A new report published in Journal of Nutrition and Metabolism suggests that eating foods or drinking beverages with fructose may increase risk of endothelial dysfunction, insulin resistance/diabetes mellitus type 2 and hypertension. Z. Khitan and D. H. Kim, the authors of the report, from Marshall University Joan Edwards School of Medicine in Huntington, WV, USA say that uric acid resulting from uncontrolled fructose metabolism is the risk factor for metabolic syndrome and diabetes mellitus. What happens, according to the report, after fructose is ingested is that the sugar in the liver bypasses two highly...
  • Study on fructose prompts criticism from corn refiners

    07/15/2013 12:21:38 PM PDT · by neverdem · 48 replies
    Winston-Salem Journal ^ | July 14, 2013 | Richard Craver
    A Wake Forest Baptist Medical Center study on dietary fructose has provided more evidence of the potential for controversy when researchers target products affecting consumer spending and corporate profits. This time, researchers are on the receiving end of sharp criticism from the Corn Refiners Association after reporting that fructose rapidly caused liver damage even without weight gain with primates.The researchers acknowledged when they released the study results that the role of dietary fructose in the development of obesity and fatty liver diseases remains controversial. Researchers determined that over a six-week study period, liver damage more than doubled in the monkeys...
  • 3-drug combination stabilizes new onset of type-2 diabetes

    07/02/2013 5:34:19 PM PDT · by neverdem · 24 replies
    eMaxHealth ^ | June 25, 2013 | Kathleen Blanchard RN
    A new study shows patients newly diagnosed with type-2 diabetes fare better when they are given a 3-drug combination compared to conventional therapy with one anti-diabetic medication. The finding that comes from researchers at University of Texas Health Science Center at San Antonio was presented June 22 at the 73rd Scientific Sessions of the American Diabetes Association in Chicago.Ralph DeFronzo, M.D., chief of the Diabetes Division in the School of Medicine at The University of Texas Health Science Center at San Antonio presented findings from a two-year study that included 134 participants at the University Health System's Texas Diabetes Institute.The...
  • Fat Cells Feel the Cold, Burn Calories for Heat

    07/01/2013 10:47:23 PM PDT · by neverdem · 9 replies
    ScienceNOW ^ | 1 July 2013 | Elizabeth Norton
    Enlarge Image Burning fat in the cold. White fat cells sense cold directly, and release energy to warm up. Credit: Biophoto Associates/Science Source Transforming fat cells into calorie-burning machines may sound like the ultimate form of weight control, but the idea is not as far-fetched as it sounds. Unexpectedly, some fat cells directly sense dropping temperatures and release their energy as heat, according to a new study; that ability might be harnessed to treat obesity and diabetes, researchers suggest. Fat is known to help protect animals from the cold—and not only by acting as insulation. In the early 1990s,...
  • Drug Appears To Work For Weight-Loss In U-M Study

    07/01/2013 8:18:52 PM PDT · by neverdem · 29 replies
    CBS News ^ | July 1, 2013 | NA
    Obese mice were given the drug Amlexanox lost weight. (credit: University of Michigan)ANN ARBOR (WWJ) - Could a drug used to treat canker sores be a miracle weight-loss solution? Researchers at University of Michigan are working to find out.Back in February, U-M researchers discovered that mice given the prescription drug, Amlexanox, lost weight without diet or exercise. Now, Dr. Elif Oral, an associate professor of internal medicine at U-M’s Metabolism, Endocrinology & Diabetes (MEND) division, is beginning the first human study to determine whether the drug will have the same effect in people.“The weight loss together in improved glucose metabolism...
  • Psyllium helps fight type 2 diabetes mellitus

    06/30/2013 3:16:07 PM PDT · by neverdem · 17 replies
    FOODCONSUMER ^ | June 27, 2013 | David Liu
    A new study in Bioactive Carbohydrates and Dietary Fibre suggests that taking a dietary supplement called psyllium can help control blood sugar in patients with type 2 diabetes mellitus even if they are taking antidiabetic medications and using a restricted diet. Psyllium is a plant whose seeds are used commercially to produce mucilage which is is a thick, gluey material full of a polar glycoprotein and an exopolysaccharide. Mucilage is found high in flaxseeds. The double blind, placebo controlled clinical trial led by N. Mark and colleagues from Duke University Medical Center in Durham, NC shows that taking 3.4 grams...
  • Don't pull diabetes drug Avandia off the market, FDA panel urges

    06/07/2013 8:48:39 PM PDT · by neverdem · 3 replies
    NBC News ^ | 2013/06/06 | Maggie Fox
    The controversial diabetes drug Avandia should stay on the market for now, with relaxed restrictions on its use, Food and Drug Administration advisers said on Thursday.The FDA has been reconsidering its approval of Avandia, which was the world’s No. 1 diabetes drug until research showed it could raise the risk of heart attacks and other heart dangers. Since then, its use has been heavily restricted and prescriptions have plummeted, and the FDA wanted to know if it was worth even keeping the drug on the market.The agency’s expert panel of advisers said the data is clearly confusing and they were...
  • Obesity surgery can stop diabetes better than drugs -- with risks

    06/07/2013 8:27:36 PM PDT · by neverdem · 13 replies
    Associated Press ^ | 2013/06/05 | Lindsay Tanner
    Obesity surgery worked much better at reducing and even reversing diabetes than medication and lifestyle changes in one of the most rigorous studies of its kind. But the researchers and others warn that possible serious complications need to be considered. The yearlong study indicates that the most common weight-loss surgery, gastric bypass, can effectively treat diabetes in patients with mild to moderate obesity about 50 to 70 pounds overweight, the researchers reported Tuesday in the Journal of the American Medical Association. Other studies have shown the operation can reverse diabetes in severely obese patients, although sometimes the disease comes...
  • Brown Fat Cell Discovery May Lead to Treatment of Obesity

    05/30/2013 3:18:21 PM PDT · by neverdem · 24 replies
    Sci-News.com ^ | May 9, 2013 | NA
    A new study by scientists at Sahlgrenska Academy, Sweden, shows that humans have two different types of brown fat cells, not one as previously thought.Newly identified type of brown adipocyte (University of Gothenburg) According to scientists, the body’s brown fat cells play a key role in the development of obesity and diabetes. Unlike white fat cells, which store the body’s surplus energy in the form of fat, brown fat cells have the unique property of being able to burn energy and turn it into heat.The new research published in the journal Nature Medicine reveals that people have at least two...
  • The Scheme to Make America Fat - Can Americans become thinner?

    05/12/2013 2:37:18 PM PDT · by neverdem · 121 replies
    American Spectator ^ | 5.10.13 | MARTA H. MOSSBURG
    In the 2008 Pixar movie WALL.E, humans so clogged up the earth with garbage they had to move to spaceships. Motorized chairs ferried the obese blobs portraying people of the future, who sipped liquids from massive cups and sat mesmerized by video screens. It was both funny and scary in its assessment of Americas throw-away, fast-food culture where convenience is everything and self-control and direction outsourced to technology. At the time of the movie it was part of an emerging chorus of voices decrying Americans growing girth. Five years later it is almost impossible to go a day without seeing...
  • Discovery of new hormone opens door to new type 2 diabetes treatment

    05/08/2013 7:07:15 AM PDT · by Pining_4_TX · 8 replies
    Science Daily ^ | May 7, 2013 | Harvard School of Public Health
    Harvard School of Public Health (HSPH) researchers have discovered that a particular type of protein (hormone) found in fat cells helps regulate how glucose (blood sugar) is controlled and metabolized (used for energy) in the liver. Using experimental models and state-of-the-art technology, the scientists found that switching off this protein leads to better control of glucose production from the liver, revealing a potential new target that may be used to treat type 2 diabetes and other metabolic diseases. The study appears online in the May 7, 2013 issue of Cell Metabolism.
  • Simple Tool Stratifies Mortality Risk in Type 2 Diabetes

    05/13/2013 11:51:28 AM PDT · by Stoat · 16 replies
    Medscape Medical News ^ | May 13, 2013 | Marlene Busko
    Simple Tool Stratifies Mortality Risk in Type 2 Diabetes Marlene Busko May13,2013 Researchers have created anonline mortality-risk calculatorfor patients with type 2 diabetes, which stratifies patients into low, medium, or high risk of dying from any cause within 2 years. By plugging in values for 9 readily available patient characteristics age, body mass index (BMI), diastolic blood pressure, LDL cholesterol, triglycerides, HDL cholesterol, urine albumin-to-creatinine ratio, antihypertensive treatment, and insulin therapy a physician can quickly determine whether a patient has a high risk for death. "The novelty and the importance of this study is that we provide...
  • Discovery in Neuroscience Could Help Re-Wire Appetite Control

    04/06/2013 9:05:01 PM PDT · by neverdem · 10 replies
    ScienceDaily ^ | Apr. 5, 2013 | NA
    Researchers at the University of East Anglia (UEA) have made a discovery in neuroscience that could offer a long-lasting solution to eating disorders such as obesity. It was previously thought that the nerve cells in the brain associated with appetite regulation were generated entirely during an embryo's development in the womb and therefore their numbers were fixed for life. But research published today in the Journal of Neuroscience has identified a population of stem cells capable of generating new appetite-regulating neurons in the brains of young and adult rodents. Obesity has reached epidemic proportions globally. More than 1.4 billion adults...
  • Experts: New diabetes treatment flushes sugar, calories out of body

    04/05/2013 12:59:11 PM PDT · by neverdem · 68 replies
    KVUE ^ | April 3, 2013 | Karen Grace
    A new diabetes drug that hit the market in the past week boasts it can drop your glucose levels and flush out "guilty" calories every time you use the bathroom. Experts say that every time the patient urinates, out goes all the unwanted sugar and calories. Doctors say this drug could even help prevent Type 2 diabetes. KVUE's sister station KENS went behind closed doors at the Veterans Affairs hospital to witness clinical trials for other drugs similar to Invokana. Last Friday, the FDA approved Invokana, a drug experts are hailing as a game changer for Type 2 diabetes treatment....
  • Vitamin D may lower diabetes risk for obese kids

    03/27/2013 11:20:24 PM PDT · by neverdem · 29 replies
    Futurity ^ | March 27, 2013 | NA
    U. MISSOURI (US) — Vitamin D supplements can help obese children and teens control their blood-sugar levels, which may help lower their risk of developing Type 2 diabetes.“By increasing vitamin D intake alone, we got a response that was nearly as powerful as what we have seen using a prescription drug,” says Catherine Peterson, associate professor of nutrition and exercise physiology at the University of Missouri. “We saw a decrease in insulin levels, which means better glucose control, despite no changes in body weight, dietary intake, or physical activity.”For the study, published in the American Journal of Clinical Nutrition, researchers...
  • Global Sugar Intake Behind The Rise In Type 2 Diabetes

    03/07/2013 2:18:50 PM PST · by neverdem · 25 replies
    redOrbit ^ | February 28, 2013 | Lawrence LeBlond
    More than 350 million people worldwide are believed to have diabetes, and for years health experts have debated on what the exact driver of the illness has been. While sugar intake has been viewed as a culprit in many eyes, scientists have long refuted that conjecture and attributed the global health crisis to too much overall food intake and obesity. But a new finding by three California universities – Stanford, UC-Berkeley and UCSF – suggests through compelling evidence that Type 2 diabetes is being largely driven by the rising consumption of sugary foods and drinks. This evidence comes in the...
  • Is BPA just an 'innocent bystander'?

    03/04/2013 1:48:12 AM PST · by neverdem · 13 replies
    Chemistry World ^ | 17 February 2013 | Patrick Walter
    Question marks have been raised over whether the levels of bisphenol A (BPA) that people are routinely exposed to are high enough to cause the diseases that have been linked to the controversial chemical. An analysis by Justin Teeguarden, a systems toxicologist at the Pacific Northwest National Laboratory, US, makes the bold claim that many of the animal tests that demonstrate that BPA may be a contributory factor in diseases like type 2 diabetes, obesity and heart disease have been elucidated using concentrations much greater than those ever found in humans.‘The old saw that correlation is not causation may hold...
  • Insulin levels wax and wane daily - Modern life may clash with hormones natural cycle

    02/27/2013 11:40:44 AM PST · by neverdem · 12 replies
    Science News ^ | February 22, 2013 | Tina Hesman Saey
    Like the sun, insulin levels rise and fall in a daily rhythm. Disrupting that cycle may contribute to obesity and diabetes, a new study suggests. Many body systems follow a daily clock known as a circadian rhythm. Body temperature, blood pressure and the release of many hormones are on circadian timers. But until now, no one had shown that insulin a hormone that helps control how the body uses sugars for energy also has a daily cycle. Working with mice, researchers at Vanderbilt University in Nashville have found that rodents are more sensitive to insulins effects at certain...
  • Mediterranean diet good for diabetes, study shows

    02/06/2013 11:49:11 PM PST · by neverdem · 55 replies
    San Jose Mercury News ^ | 02/06/2013 | Kathryn Doyle
    Diets lean on meat and rich in healthy fats like olive oil were most effective at promoting weight loss and lowering blood sugar among people with diabetes in a review of evidence from the last 10 years. Benefits were also seen with diets low in carbohydrates, high in protein or low in simple sugars. "If you look at different types of diets, these four can improve various aspects of diabetes control," lead author Dr. Olubukola Ajala, a diabetes specialist at Western Sussex Hospitals in the UK, told Reuters Health. More than 24 million Americans have type 2 diabetes. People with...
  • First-Ever Guidelines for Children With Diabetes (type 2!)

    01/29/2013 6:54:23 PM PST · by neverdem · 7 replies
    Medscape Medical News ^ | Jan. 29, 2013 | Miriam E. Tucker
    The American Academy of Pediatrics has issued the first-ever guidelines for the management of type 2 diabetes in children and teens. Type 2 diabetes is rising rapidly among children and teens because of soaring obesity rates. It now accounts for up to 1 in 3 new cases of diabetes in those younger than 18. These guidelines are for children between the ages of 10 and 18. "Few providers have been trained in managing type 2 diabetes in children and, to date, few medications have been evaluated for safety and [effectiveness] in children," says co-author Janet Silverstein, MD, professor of pediatrics...
  • Treat obesity as physiology, not physics (Gary Taubes)

    12/14/2012 6:41:08 PM PST · by neverdem · 115 replies
    Nature News ^ | 12 December 2012 | Gary Taubes
    The energy inenergy out hypothesis is not set in stone, argues Gary Taubes. It is time to test hormonal theories about why we get fat. It is better to know nothing, wrote French physiologist Claude Bernard in An Introduction to the Study of Experimental Medicine (1865), than to keep in mind fixed ideas based on theories whose confirmation we constantly seek. Embracing a fixed idea is one of the main dangers in the evolution of any scientific discipline. Ideally, errors will be uncovered in the trial-by-fire of rigorous testing and the science will right itself. In rare cases, however, an...
  • More than 3,000 epigenetic switches control daily liver cycles

    12/14/2012 2:34:22 PM PST · by neverdem · 7 replies
    Biology News Net ^ | December 11, 2012 | NA
    Thousand of epigenetic switches in the liver control whether genes turn on or off in response to circadian cycles. The figure illustrates daily changes, every six hours, in five different...When it's dark, and we start to fall asleep, most of us think we're tired because our bodies need rest. Yet circadian rhythms affect our bodies not just on a global scale, but at the level of individual organs, and even genes. Now, scientists at the Salk Institute have determined the specific genetic switches that sync liver activity to the circadian cycle. Their finding gives further insight into the mechanisms behind...
  • Weight Loss Surgery May Not Combat Diabetes Long-Term

    11/29/2012 8:28:17 PM PST · by neverdem · 15 replies
    NY Times ^ | NOVEMBER 28, 2012 | Anahad O'Connor
    Weight loss surgery, which in recent years has been seen as an increasingly attractive option for treating Type 2 diabetes, may not be as effective against the disease as it was initially thought to be, according to a new report. The study found that many obese Type 2 diabetics who undergo gastric bypass surgery do not experience a remission of their disease, and of those that do, about a third redevelop diabetes within five years of their operation. The findings contrast with the growing perception that surgery is essentially a cure for Type II diabetes. Earlier this year, two widely...
  • High-fructose corn syrup linked to type 2 diabetes

    11/28/2012 12:58:27 PM PST · by neverdem · 113 replies
    The Ssaratogian ^ | November 28, 2012 | Annie Hauser
    Countries using high-fructose corn syrup have diabetes rates 20 percent higher than countries that do not, a new international analysis finds. High-fructose corn syrup (HFCS) in national food supplies around the world might help explain the rising rates of type 2 diabetes around the world, researchers at the University of Southern California and the University of Oxford report in the journal Global Public Health. After studying 42 countries, researchers found that those that use HFCS in their food supply had a 20 percent higher prevalence of diabetes than those that did not use HFCS, suggesting an association with diabetes independent...
  • Hormone Combination Effective and Safe for Treating Obesity in Mice

    11/13/2012 10:07:02 PM PST · by neverdem · 25 replies
    ScienceDaily ^ | Nov. 13, 2012 | NA
    Scientists at Indiana University and international collaborators have found a way to link two hormones into a single molecule, producing a more effective therapy with fewer side effects for potential use as treatment for obesity and related medical conditions. The studies were carried out in the laboratories of Richard DiMarchi, the Standiford H. Cox Distinguished Professor of Chemistry and the Linda & Jack Gill Chair in Biomolecular Sciences in the IU Bloomington College of Arts and Sciences, and of Matthias Tschp, professor of medicine and director of the Institute of Diabetes and Obesity, Helmholtz Center Munich, Germany. Results were published...
  • High Stress Can Make Insulin Cells Regress

    10/08/2012 2:41:59 AM PDT · by neverdem · 11 replies
    NY Times ^ | October 1, 2012 | AMANDA SCHAFFER
    THE HYPOTHESIS In Type 2 diabetes, insulin-producing cells revert to an earlier developmental state. THE INVESTIGATORS Chutima Talchai and Dr. Domenico Accili, Columbia University... The hormone insulin helps shuttle glucose, or blood sugar, from the bloodstream into individual cells to be used as energy. But the body can become resistant to insulin, and the beta cells of the pancreas, which produce the hormone, must work harder to compensate. Eventually, the thinking goes, they lose the ability to keep up. We used to say that the beta cells poop out, said Alan Saltiel, director of the Life Sciences Institute at the...
  • Open Season on Salt: What the Science on Hypertension Really Shows

    09/27/2012 11:15:25 PM PDT · by neverdem · 51 replies
    Scientific American ^ | September 26, 2012 | Melinda Wenner Moyer
    Shedding pounds may be a better way to promote cardiovascular health than avoiding the saltshakerThe latest news reports about salt are enough to make a parent ponder a household ban on pizza and cold cuts. A study published last week in Pediatrics found that children eat, on average, 3.4 grams of sodium daily—more than twice the amount recommended for adults by the Institute of Medicine (IOM). News outlets, including the Associated Press and USA Today, explained that, according to the study, the quarter of American kids who eat the most sodium are twice to three times as likely to develop...
  • Turning White Fat Into Energy-Burning Brown Fat: Hope for New Obesity and Diabetes Treatments

    08/06/2012 1:46:58 AM PDT · by neverdem · 17 replies
    ScienceDaily ^ | Aug. 2, 2012 | NA ,
    Columbia University Medical Center (CUMC) researchers have identified a mechanism that can give energy-storing white fat some of the beneficial characteristics of energy-burning brown fat. The findings, based on studies of mice and of human fat tissue, could lead to new strategies for treating obesity and type 2 diabetes. The study was published August 2 in the online edition of the journal Cell. Humans have two types of fat tissue: white fat, which stores excess energy in the form of triglycerides, and brown fat, which is highly efficient at dissipating stored energy as heat. Newborns have a relative abundance of...
  • New Brain Target for Appetite Control Identified

    06/08/2012 11:13:19 PM PDT · by neverdem · 3 replies
    Finding raises hopes for new anti-obesity medications New York, NY (June 7, 2012) Researchers at Columbia University Medical Center (CUMC) have identified a brain receptor that appears to play a central role in regulating appetite. The findings, published today in the online edition of Cell, could lead to new drugs for preventing or treating obesity. Weve identified a receptor that is intimately involved in regulating food intake, said study leader Domenico Accili, MD, professor of Medicine at CUMC. What is especially encouraging is that this receptor belongs to a class of receptors that turn out to be good targets...
  • Study: 1 in 4 kids diabetic or pre-diabetic

    05/21/2012 10:06:13 PM PDT · by neverdem · 20 replies
    KFVS (CAPE GIRARDEAU, MO) ^ | May 21, 2012 | Christy Millweard
    CAPE GIRARDEAU, MO (KFVS) - Recent data shows a shocking jump in youth diabetes. A new study in the Journal of the American Academy of Pediatrics said 1 out of 4 youth in the U.S. is diabetic or pre-diabetic. The study looked at kids under 20 years old. It showed between 2000 and 2008, the percentage of teens with pre-diabetes and diabetes jumped from nine to 23 percent. Local Diabetes Educator Janet Stewart at Southeast Health said in the past decade she's seen the number of kids with Type 1 or Type 2 diabetes jump almost 30 percent. She said...
  • Obesity-Linked Diabetes in Children Resists Treatment

    04/30/2012 8:05:05 PM PDT · by neverdem · 29 replies
    NY Times ^ | April 29, 2012 | Denise Grady
    Obesity and the form of diabetes linked to it are taking an even worse toll on America’s youths than medical experts had realized. As obesity rates in children have climbed, so has the incidence of Type 2 diabetes, and a new study adds another worry: the disease progresses more rapidly in children than in adults and is harder to treat. “It’s frightening how severe this metabolic disease is in children,” said Dr. David M. Nathan, an author of the study and director of the diabetes center at Massachusetts General Hospital. “It’s really got a hold on them, and it’s hard...
  • Shift workers 'risking' Type 2 diabetes and obesity

    04/14/2012 7:41:00 PM PDT · by neverdem · 37 replies
    BBC News ^ | 11 April 2012 | James Gallagher
    Shift workers getting too little sleep at the wrong time of day may be increasing their risk of diabetes and obesity, according to researchers.The team is calling for more measures to reduce the impact of shift working following the results of its study.Researchers controlled the lives of 21 people, including meal and bedtimes.The results, published in Science Translational Medicine, showed changes to normal sleep meant the body struggled to control sugar levels.Some participants even developed early symptoms of diabetes within weeks.Shift work has been associated with a host of health problems. Doctors at Brigham and Women's Hospital, in the US,...
  • Really? Ulcers Increase the Risk of Diabetes

    03/29/2012 7:57:54 PM PDT · by neverdem · 7 replies
    NY Times ^ | March 26, 2012 | ANAHAD O'CONNOR
    Poor diet, a lack of exercise, excess weight and genetics are the usual risk factors for Type 2 diabetes. But a new line of research suggests that in some cases, there may be a surprising contributor: the stomach bacterium known as Helicobacter pylori.People who acquire H. pylori typically in childhood are at a greater risk of ulcers and gastric cancer. But H. pylori also is thought to affect two digestive hormones involved in hunger and satiety.The belief is that the bacterium increases levels of ghrelin, the "hunger hormone," which is known to promote weight gain. At the same...