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The 'Garbage Truck' of the Human Brain: New Clues to Treating Alzheimer's
Science World Report ^ | Jun 28, 2013 | Catherine Griffin

Posted on 06/28/2013 11:08:37 PM PDT by neverdem

The brain works like a complex machine, sending electrical signals that allow us to perceive and understand the world around us. Now, scientists have discovered a new system in this brain that acts as a "garbage truck," removing waste that might affect the brain. The findings could have large implications for treating neurological disorders like Alzheimer's disease.

The body defends the brain like a fortress, ringing it with a complex system of gateways that control which molecules can enter and exit. This "blood-brain barrier" was known to exist for quite some time, but it's only now that researchers are beginning to understand how it functions. This latest system for waste removal, for example, is just part of the wider picture.

Waste removal is an essential biological function. The lymphatic system, a circulatory network of organs and vessels, performs this task in most of the body. Yet the lymphatic system doesn't extend to the brain. Because of this, scientists have never fully understood what the brain does with its own waste.

In order to better understand how the brain might remove waste, the researchers used a new imaging technology called two-photon microscopy. This allowed them to peer deep within the living brains of mice. The scientists found what amounts to an extensive plumbing system responsible for flushing waste from throughout the brain.

The brain itself is surrounded by a membrane called the arachnoid and bathed in cerebral spinal fluid (CSF). CSF flows into the interior of the brain through the same pathways as the arteries that carry blood and is drawn into brain tissue via a system of conduits that are controlled by a type of support cells in the brain, known as glia--in this case, astrocytes. The CSF is flushed through the brain tissue at high speeds, which sweeps away excess "garbage" that might be located in the brain. The scientists decided to coin this newly discovered system the "glymphatic system."

Yet this system doesn't just tell us a bit more about the brain. It also may have implications for diseases associated with it.

"The idea that 'dirty brain' diseases like Alzheimer's may result from a slowing down of the glymphatic system as we age is a completely new way to think about neurological disorders," said Maiken Nedergaard, one of the researchers, in a news release. "It also presents us with a new set of targets to potentially increase the efficiency of glymphatic clearance and, ultimately, change the course of these conditions."

The findings are published in the journal Science.


TOPICS: Culture/Society; Extended News
KEYWORDS: alzheimers; csf; glia; glymphatics; imaging; neurology; twophotonmicroscopy

1 posted on 06/28/2013 11:08:37 PM PDT by neverdem
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To: texas booster

Ping


2 posted on 06/28/2013 11:09:43 PM PDT by neverdem (Register pressure cookers! /s)
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To: neverdem

.


3 posted on 06/28/2013 11:15:37 PM PDT by doc1019 (There is absolutely no difference between pro-choice and pro-abortion.)
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>> neurological disorders

I’m anticipating an increasing connection between neurological and nerve disorders related to nutritional deficiencies.


4 posted on 06/29/2013 1:50:07 AM PDT by Gene Eric (Don't be a statist!)
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To: neverdem

The brain does not work like a machine.


5 posted on 06/29/2013 5:15:43 AM PDT by I want the USA back (If I Pi$$ed off just one liberal today my mission has been accomplished.)
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To: Gene Eric
I’m anticipating an increasing connection between neurological and nerve disorders related to nutritional deficiencies.

..or additives like substitute sugars...

I can't tell you have much better I feel and think more clearly after I stopped drinking diet soda or any sugar free products made with artificial sweeteners three months ago...

6 posted on 06/29/2013 5:44:34 AM PDT by Popman (Godlessness is always the first step to the concentration camp.)
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To: Popman
I can't tell you have much better I feel and think more clearly after I stopped drinking diet soda or any sugar free products made with artificial sweeteners three months ago...

What do you think about Truvia?

7 posted on 06/29/2013 5:47:17 AM PDT by IamConservative (The soul of my lifes journey is Liberty!)
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To: I want the USA back
The brain does not work like a complex machine.

That's where I stopped reading...

The writer either thinks we are morons or he is one to think our brain can be compared to a complex machine...

8 posted on 06/29/2013 5:47:46 AM PDT by Popman (Godlessness is always the first step to the concentration camp.)
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To: IamConservative
What do you think about Truvia?

I really don't know...if it is a chemical I try not to put in my body

My food philosophy is real simple now..

If it grows in the ground or on a tree or it is an animal (cattle, pig, lamb, chicken) or swims in the water ...I will eat it...

Nothing processed or man made...(except coffee..)

9 posted on 06/29/2013 5:57:40 AM PDT by Popman (Godlessness is always the first step to the concentration camp.)
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To: Popman; IamConservative

Truvia is made from the leaves of the stevia plant, the leaves of which are basically a natural “artificial” sweetener.

I grew some in the herb garden a couple years ago, it is pretty interesting stuff.


10 posted on 06/29/2013 6:01:31 AM PDT by FreedomPoster (Islam delenda est)
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To: Popman
If it grows in the ground or on a tree or it is an animal (cattle, pig, lamb, chicken) or swims in the water ...I will eat it...

My philosophy exactly.

11 posted on 06/29/2013 6:04:22 AM PDT by IamConservative (The soul of my lifes journey is Liberty!)
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To: IamConservative

Might want to add a few more exceptions still. There are some animals that will sicken or kill you if eaten, and far more plants that will do the same.


12 posted on 06/29/2013 6:14:33 AM PDT by RegulatorCountry
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To: neverdem

thanks for the post
This is very interesting information.


13 posted on 06/29/2013 6:23:38 AM PDT by khelus
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To: I want the USA back
The brain does not work like a machine.

Actually, it works more like a pump. The brain pulsates, expanding and contracting about 12 times a minute. I heard a doctor describe it. He said schizophrenia brains pulsate about 8 times a minute. Using cranial manipulation to speed up the pulsation temporarily normalizes the schizophrenic.

14 posted on 06/29/2013 7:57:19 AM PDT by aimhigh (Guns do not kill people. Abortion kills people.)
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To: neverdem

I suspect this is a reason that long-term aerobic exercise has a rejuvenating/health prolonging effect, it gets ALL the fluids moving, not just the blood.


15 posted on 06/29/2013 9:56:03 AM PDT by Wonder Warthog
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