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Grapefruit Is a Culprit in More Drug Reactions
NY Times ^ | DECEMBER 17, 2012 | RONI CARYN RABIN

Posted on 12/18/2012 8:13:07 PM PST by neverdem

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Grapefruit Interacting Drugs and Associated Oral Bioavailability, Adverse Event(s), Risk Ranking and Potential Alternative Medications(PDF)

Type 2 diabetics taking repaglinide, aka Prandin, and saxagliptin, aka Onglyza, beware of the mentioned foods.

1 posted on 12/18/2012 8:13:19 PM PST by neverdem
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To: neverdem

Maybe John Boenher will suggest we have a frank discussion about citrus.


2 posted on 12/18/2012 8:19:22 PM PST by SpaceBar
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To: neverdem

I’m not sure if suggesting a smaller amount of medication plus grapefruit juice, as a cost saver, would be a joke or not. I’d guess that the grapefruit juice would have to be pretty well calibrated as well, not just something from the grocery store.


3 posted on 12/18/2012 8:22:03 PM PST by jiggyboy (Ten percent of poll respondents are either lying or insane)
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To: neverdem
Grapefruit Is a Culprit in More Drug Reactions

That's why it is a good idea to read the pamphlets included with your medications.

4 posted on 12/18/2012 8:24:01 PM PST by Alaska Wolf (Carry a Gun, It's a Lighter Burden Than Regret)
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To: neverdem

I don’t eat or drink grapefruit, but I do drink a bit of orange juice at breakfast. I’ll have to check that out, I guess, since I take atorvastatin.


5 posted on 12/18/2012 8:30:18 PM PST by Cicero (Marcus Tullius)
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To: neverdem

Thank you for this. I had known that grapefruit juice and other citrus interferes with some drugs, but didn’t know about the statins.


6 posted on 12/18/2012 8:33:08 PM PST by MestaMachine (It's the !!!!TREASON!!!!, stupid!)
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To: neverdem
I'm on Lipitor and the instructions say not to have grapefruit juice. I really miss grapefruit juice - I don't have a sweet tooth - I have an anti-sweet tooth. I was also on verapamil for a while.



Keep Faith with the Fallen of Benghazi! Let the Obama Regime, for once, tell the Truth!

Fiat Justitia, Ruat Coelum!

Genuflectimus non ad principem sed ad Principem Pacis!

Listen, O isles, unto me; and hearken, ye people, from far; The LORD hath called me from the womb; from the bowels of my mother hath he made mention of my name. (Isaiah 49:1 KJV)

7 posted on 12/18/2012 8:41:14 PM PST by ConorMacNessa (HM/2 USN, 3/5 Marines RVN 1969 - St. Michael the Archangel defend us in Battle!)
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To: neverdem

It is interesting since Grapefruit juice is my least favorite type of juice and I’ve very rarely had it. Grapefruit sparkling water, on the other hand I’ve indulged in that more.


8 posted on 12/18/2012 8:48:16 PM PST by Merta (I blame Adam)
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To: neverdem
From MedicineNet.com: Large quantities of grape fruit juice (>1 quart daily) also will increase blood levels of simvastatin and should be avoided.
9 posted on 12/18/2012 8:51:05 PM PST by Brandonmark (OWCM is The new American Minority!)
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To: Judith Anne; 2ndreconmarine; Fitzcarraldo; Covenantor; rejoicing; Rushmore Rocks; ...

Health & science stories like this one is one of the few reasons I check out the NY Times. Most patients are unaware of adverse food and drug interactions, unless it’s printed on the label of the drug container.

This one of those rare everybody on my lists gets pinged, including some medical docs who have identified themselves as such that are not on any list. Comment# 1 has a link to the list of these drugs. From its URL it looks like it was in the Journal of the Canadian Medical Association.

Happy Chanukah, Merry Christmas and Happy New Year!


10 posted on 12/18/2012 8:53:59 PM PST by neverdem ( Xin loi min oi)
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To: Judith Anne; 2ndreconmarine; Fitzcarraldo; Covenantor; rejoicing; Rushmore Rocks; ...

Health & science stories like this one is one of the few reasons I check out the NY Times. Most patients are unaware of adverse food and drug interactions, unless it’s printed on the label of the drug container.

This one of those rare everybody on my lists gets pinged, including some medical docs who have identified themselves as such that are not on any list. Comment# 1 has a link to the list of these drugs. From its URL it looks like it was in the Journal of the Canadian Medical Association.

Happy Chanukah, Merry Christmas and Happy New Year!


11 posted on 12/18/2012 8:54:59 PM PST by neverdem ( Xin loi min oi)
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To: neverdem

A while back, someone who was a medical transcriber told me, that, grapefruit juice was a trick older folks used with their meds to save money. They’d take half the dose prescribed with a glass of grapefruit juice. The medical establishment would frown on that because they would lose money... and it would mess up their statistics.

I don’t know how much of that is true.


12 posted on 12/18/2012 8:59:33 PM PST by 1_Rain_Drop
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To: neverdem

13 posted on 12/18/2012 9:00:01 PM PST by Revolting cat! (Bad things are wrong! Ice cream is delicious!)
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To: neverdem; a fool in paradise; Slings and Arrows

14 posted on 12/18/2012 9:01:02 PM PST by Revolting cat! (Bad things are wrong! Ice cream is delicious!)
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To: neverdem

Thanks for the ping!


15 posted on 12/18/2012 9:02:20 PM PST by Alamo-Girl
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To: neverdem

Neverdem: JA, first on your ping list, is dearly departed. I still think of her frequently.


16 posted on 12/18/2012 9:02:34 PM PST by steve86 (Acerbic by Nature, not Nurture™)
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To: neverdem
Since grapefruit juice is cheaper than prescription drugs - maybe a smaller dose and a glass of juice would be a better idea...
17 posted on 12/18/2012 9:07:52 PM PST by GOPJ (Detroit should be renamed 'Michael Mooresville'...)
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To: neverdem

Thanks for the info. Now, how do I stop these darn kidney stones? Yeah, I drink lots of lemonade.


18 posted on 12/18/2012 9:11:38 PM PST by doug from upland (Obama and the leftists - destroying our country one day at a time)
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To: neverdem

Already gnu about the adjuvant properties of grapefruit, but thanks, more quantitative information is always desirable. I’d heard about it effectively doubling the dose, but never a multiple of five.


19 posted on 12/18/2012 9:12:22 PM PST by Carry_Okie (The Slave Party: advancing indenture since 1787.)
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To: steve86

I miss her, too. :(


20 posted on 12/18/2012 9:13:02 PM PST by Politicalmom (Liberalism. Ideas so great they have to be mandatory.-FReeper Osage Orange)
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To: neverdem

What happened to JA?
Regarding the grapefruit juice, I’d drink it instead. Skip the pharmaceuticals, they are all poison to me.
Merry Christmas all!


21 posted on 12/18/2012 9:13:50 PM PST by acapesket
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To: neverdem

My son emailed a similar story to me last week because he knows I usually slog my small handful of daily vitamins down with grapefruit juice. It never seemed to bother me, but now I wonder if there is any positive or adverse effect on my vitamins (Ester-C cap, B-Complex cap, D gelcap, CoEnzyme Q10 gelcap)?


22 posted on 12/18/2012 9:24:33 PM PST by Lancey Howard
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To: neverdem
Per the Mayo Clinic website:
Certain chemicals that grapefruit products and citrus fruits contain can interfere with the enzymes that break down (metabolize) various medications in your digestive system. As a result, more medication stays in your body. This can increase the potency of your medication to potentially dangerous levels, causing serious side effects.

23 posted on 12/18/2012 9:25:47 PM PST by Brandonmark (OWCM is The new American Minority!)
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To: neverdem

I’m warned not to eat natural licorice while taking my B.P. medication. Until I read that I wasn’t even aware that there was a “natural” and “unnatural” licorice.


24 posted on 12/18/2012 9:26:54 PM PST by Graybeard58 ("Civil rights” leader and MSNB-Hee Haw host Al Sharpton - Larry Elder)
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To: steve86

I just heard about Judith Anne via FReepmail. It’s removed.


25 posted on 12/18/2012 9:33:52 PM PST by neverdem ( Xin loi min oi)
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To: neverdem

They finally have a safe drug that cures everything:
http://www.youtube.com/watch?v=EP9B3NBFD2M


26 posted on 12/18/2012 9:35:18 PM PST by Born to Conserve
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To: acapesket
What happened to JA?

I just read that she had a stroke and died shortly afterwards.

27 posted on 12/18/2012 9:38:52 PM PST by neverdem ( Xin loi min oi)
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To: Graybeard58

I actually take extra-strength licorice extract while taking my statin (I realize you are not talking about a statin). But the extract is deglycyrrhizinated and it was that part that would cause you problems.


28 posted on 12/18/2012 9:52:31 PM PST by steve86 (Acerbic by Nature, not Nurture™)
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To: neverdem

She may still be reading threads in heaven; wouldn’t half surprise me. By now she could post some really definitive comments in the religion threads!


29 posted on 12/18/2012 9:56:29 PM PST by steve86 (Acerbic by Nature, not Nurture™)
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To: neverdem

Oh dear! I am so sorry! Nice woman, I hate it when folks pass. I will pray for her soul. God Bless.


30 posted on 12/18/2012 9:56:59 PM PST by acapesket
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To: neverdem

Earl Grey Tea also has a reaction with medications. You have to read the box and medication literature to find that out.


31 posted on 12/18/2012 10:07:55 PM PST by petitfour
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To: Alaska Wolf

Yup. I completely avoid grape fruit juice because of it’s interactions with prescription meds. Checking drug/food interactions is just as important as checking drug/drug interactions.


32 posted on 12/18/2012 10:16:00 PM PST by chessplayer
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To: Revolting cat!

Rc!, that is great!

I take Norvasc & Diovan for blood pressure, and thank God for waking up each day.

On to my NW SC country paradise at the end of the year.


33 posted on 12/18/2012 10:44:41 PM PST by onedoug
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To: neverdem

Red Grapefruit juice is my favorite juice to mix with club soda. However, since I take verapamil, I just don’t do grapefruit other than maybe once a year.

Lately my blood pressure has trended up, so maybe I should treat my self a little and have 1/4 or 1/2 cup. LOL.


34 posted on 12/18/2012 11:25:38 PM PST by greeneyes (Moderation in defense of your country is NO virtue. Let Freedom Ring.)
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To: doug from upland
Kidney stones? You have to drink huge amounts of water (or lemonade). My military-Reservist MD put me on his diet, as he suffered from kidney stones as well. How lucky is that to find a doctor with the same ailment? :)

I'm on a successful diet that excludes my favorite foods that started it all.

Excluded: chocolate, cabbage, nuts, okra, spinach, celery, kohlrabi, soy, beans, seasoned meats, milk and colored beverages.

Google oxalates.

35 posted on 12/18/2012 11:59:47 PM PST by Does so (Dims don't think ... they PLOT!)
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To: neverdem

!!!!

Wowzers.


36 posted on 12/19/2012 4:56:05 AM PST by Darksheare (Try my coffee, first one's free.....)
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To: doug from upland

“Now, how do I stop these darn kidney stones? Yeah, I drink lots of lemonade.”

a/ drink WATER AND MORE WATER.

b/ lay off dairy if the stones are calcium, and go to drug store, buy ph strips, check the ph of your urine, take inexpensive OTC sodium bicarbonate pills if too base (not acidic enough).

I am NOT an MD but I had chronic kidney stones for years and this helped immensely.

ASK YOUR DOCTOR about the above.


37 posted on 12/19/2012 5:27:16 AM PST by Yehuda
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To: neverdem

“Health & science stories like this one is one of the few reasons I check out the NY Times. “

I appreciate your desire to stay up to date on health topics, but I still say “screw the NY Times.”

Go to Drugs.com and either use their drug interaction checker or register with a no-name hotmail account for their mednotes - the latter (if not both) has been showing when grapefruits and grapefruit juice were contraindicated for prescriptions and for OTC medications for years.


38 posted on 12/19/2012 5:36:55 AM PST by Yehuda
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To: Does so; doug from upland

google chanca piedra

this supplement breaks up kidney stones

http://www.globalhealingcenter.com/natural-health/benefits-of-chanca-piedra/


39 posted on 12/19/2012 5:43:20 AM PST by freedommom
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To: neverdem

Thanks, neverdem, for the ping.

The drug, verapamil, featured in the lead, is one I take daily. I’m frightened to hear that it can cause heart block when interacting with grapefruit, but it does indeed prevent vicious migraine attacks.

I’m off grapefruit!


40 posted on 12/19/2012 6:33:38 AM PST by Jedidah
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To: neverdem

I like grapefruit, but one of my heart meds says not to eat it or drink the juice while taking it.

But here is an unaddressed question: if grapefruit increases the level of the drug, why not use grapefruit to decrease the quantity of the drug you need?

The probable answer, my educated guess: they’ll sell less of the drug that way; profit rules!


41 posted on 12/19/2012 7:47:46 AM PST by JimRed (Excise the cancer before it kills us; feed &water the Tree of Liberty! TERM LIMITS, NOW & FOREVER!)
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To: Does so

Thanks, yes I know all about oxalates and I drink so much water I run down the hall all day and night. Have not eaten meat or fowl since 1991, so I do have nuts and soy and beans and milk for protein, but I have lowered my intake of protein. A human being should not have to live without chocolate. :)


42 posted on 12/19/2012 8:01:12 AM PST by doug from upland (Obama and the leftists - destroying our country one day at a time)
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To: Yehuda

Thanks. My urologist is going to do a metabolic test on me and see if we can find some answers.


43 posted on 12/19/2012 8:02:23 AM PST by doug from upland (Obama and the leftists - destroying our country one day at a time)
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To: freedommom

Thanks. I have taken herbal supplements and for some months I have not had a stone. We will see how long it lasts. When I bowl, I typically bowl 12 games. In two hours, my water intake is now 6+ glasses. I believe I have been so physically active and did not realize I was dehydrating myself.


44 posted on 12/19/2012 8:05:31 AM PST by doug from upland (Obama and the leftists - destroying our country one day at a time)
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To: doug from upland

The prostate drug Flomax can help you pass kidney stones.


45 posted on 12/19/2012 8:10:24 AM PST by csmusaret (I will give Obama credit for one thing- he is living proof that familiarity breeds contempt.)
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To: 1_Rain_Drop; jiggyboy
Not a very good idea unless you have a good understanding of what CYP P450 enzyme is responsible for metabolizing the drug you are taking.

If it isn't the one that grapefruit juice inhibits - you will not be taking an effective dose - half the concentration is almost always not half as efficacious - usually it doesn't work at all.

Moreover there is no guarantee that the drug you are taking with grapefruit juice will maintain an efficacious level of the therapeutic long term even if it is metabolized by the correct CPY P450 enzyme - either you will not be taking enough, leading to it not working - or you would be taking too much, leading to a build up of toxic levels.

I think there would be far better avenues to save money than playing with fire drinking grapefruit juice with your medications. You might save money right into the emergency room or the morgue. Death can be a real money saver!

46 posted on 12/19/2012 8:19:13 AM PST by allmendream (Tea Party did not send GOP to D.C. to negotiate the terms of our surrender to socialism)
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To: neverdem

Maybe it’s wise to consider cutting back on medications.


47 posted on 12/19/2012 9:06:14 AM PST by Conservativegreatgrandma
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To: neverdem

Saw it on FNC last night. Dr. suggested it would be wise to also curtail other citrus as well.

A med I take says no grapefruit and I miss the stuff.


48 posted on 12/19/2012 9:28:20 AM PST by Lady Jag (If you can't make them see the light, let them feel the heat. - Reagan)
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To: 1_Rain_Drop
A while back, someone who was a medical transcriber told me, that, grapefruit juice was a trick older folks used with their meds to save money. They’d take half the dose prescribed with a glass of grapefruit juice. The medical establishment would frown on that because they would lose money... and it would mess up their statistics.

I don’t know how much of that is true.


I know personally a friend who does that with Cialis.

He says that 1/4 of a pill works like magic with some grapefruit juice.

Since Cialis is quite expensive, he saves a lot of money that way. It is also a quality of life drug and the effective dose can easily be guessed at safely.

Not that I would know otherwise of course...

I wouldn't recommend this for life saving drugs that you need to stay alive...
49 posted on 12/19/2012 9:42:02 AM PST by Bon mots (Abu Ghraib: 47 Times on the front page of the NY Times | Benghazi: 2 Times)
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To: 1_Rain_Drop
A while back, someone who was a medical transcriber told me, that, grapefruit juice was a trick older folks used with their meds to save money. They’d take half the dose prescribed with a glass of grapefruit juice. The medical establishment would frown on that because they would lose money... and it would mess up their statistics.

I don’t know how much of that is true.


...more on using GF juice with Cialis>>>
The standard dose for erectile dysfunction is 20mg., the normal pill dose. However, Cialis is also prescribed for Pulmonary and arterial hypertension, but the recommended dose is 40mg. EVERY DAY!
This leads one to believe that there is little risk in trying, say a 5mg dose with grapefruit juice.
My friend simply bites the 20 mg. pills into a quarter or third and drinks a whole glass of grapefruit juice.
(on an empty stomach, of course.)
50 posted on 12/19/2012 9:49:49 AM PST by Bon mots (Abu Ghraib: 47 Times on the front page of the NY Times | Benghazi: 2 Times)
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