Grapefruit Is a Culprit in More Drug Reactions

NY Times ^ | DECEMBER 17, 2012 | RONI CARYN RABIN

[neverdem]

Grapefruit Interacting Drugs and Associated Oral Bioavailability, Adverse Event(s), Risk Ranking and Potential Alternative Medications(PDF)

Type 2 diabetics taking repaglinide, aka Prandin, and saxagliptin, aka Onglyza, beware of the mentioned foods.

[SpaceBar]

Maybe John Boenher will suggest we have a frank discussion about citrus.

[jiggyboy]

I’m not sure if suggesting a smaller amount of medication plus grapefruit juice, as a cost saver, would be a joke or not. I’d guess that the grapefruit juice would have to be pretty well calibrated as well, not just something from the grocery store.

[Alaska Wolf]

Grapefruit Is a Culprit in More Drug Reactions

That's why it is a good idea to read the pamphlets included with your medications.

[Cicero]

I don’t eat or drink grapefruit, but I do drink a bit of orange juice at breakfast. I’ll have to check that out, I guess, since I take atorvastatin.

[MestaMachine]

Thank you for this. I had known that grapefruit juice and other citrus interferes with some drugs, but didn’t know about the statins.

[ConorMacNessa]

I'm on Lipitor and the instructions say not to have grapefruit juice. I really miss grapefruit juice - I don't have a sweet tooth - I have an anti-sweet tooth. I was also on verapamil for a while.



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[Merta]

It is interesting since Grapefruit juice is my least favorite type of juice and I’ve very rarely had it. Grapefruit sparkling water, on the other hand I’ve indulged in that more.

[Brandonmark]

From MedicineNet.com: Large quantities of grape fruit juice (>1 quart daily) also will increase blood levels of simvastatin and should be avoided.

[neverdem]

Health & science stories like this one is one of the few reasons I check out the NY Times. Most patients are unaware of adverse food and drug interactions, unless it’s printed on the label of the drug container.

This one of those rare everybody on my lists gets pinged, including some medical docs who have identified themselves as such that are not on any list. Comment# 1 has a link to the list of these drugs. From its URL it looks like it was in the Journal of the Canadian Medical Association.

Happy Chanukah, Merry Christmas and Happy New Year!

[neverdem]

Health & science stories like this one is one of the few reasons I check out the NY Times. Most patients are unaware of adverse food and drug interactions, unless it’s printed on the label of the drug container.

This one of those rare everybody on my lists gets pinged, including some medical docs who have identified themselves as such that are not on any list. Comment# 1 has a link to the list of these drugs. From its URL it looks like it was in the Journal of the Canadian Medical Association.

Happy Chanukah, Merry Christmas and Happy New Year!

[1_Rain_Drop]

A while back, someone who was a medical transcriber told me, that, grapefruit juice was a trick older folks used with their meds to save money. They’d take half the dose prescribed with a glass of grapefruit juice. The medical establishment would frown on that because they would lose money... and it would mess up their statistics.

I don’t know how much of that is true.

[Revolting cat!]

[Revolting cat!]

[Alamo-Girl]

Thanks for the ping!

[steve86]

Neverdem: JA, first on your ping list, is dearly departed. I still think of her frequently.

[GOPJ]

Since grapefruit juice is cheaper than prescription drugs - maybe a smaller dose and a glass of juice would be a better idea...

[doug from upland]

Thanks for the info. Now, how do I stop these darn kidney stones? Yeah, I drink lots of lemonade.

[Carry_Okie]

Already gnu about the adjuvant properties of grapefruit, but thanks, more quantitative information is always desirable. I’d heard about it effectively doubling the dose, but never a multiple of five.

[Politicalmom]

I miss her, too. :(