This is what my literature says.
I take a daily dose of 20mg of simvastatin for cholesterol control. I take it because I also have a mild case of diabetes.
When I was first diagnosed with the diabetes, my cholesterol reading as 204, and he (my doctor) said if I didn't have the diabetes he wouldn't be worried about my cholesterol at all.
So I took it, and saw my cholesterol levels drop to 145. That was a couple of years ago. Now it pretty much stays in the 160s.
I've been drinking grapefruit juice every day for 40 years. I love the stuff. But when I went on the simvastatin, I stopped taking it...for a while.
Now, in the mornings, I'll have a bit that covers a little more than the bottom of a glass just so I can enjoy it while washing down a One-A-Day vitamin pill (50+ for men, of course!)
I tell the doc when I have cold coming on, and we both agree to suspend the simvastatin for a couple of days while drinking the grapefruit juice to combat the cold.
Hey, it works for me!
But my case is probably atypical, and I agree with those posters who say if you're taking potentially life-saving drugs, do the smart thing, and follow the instructions - to the letter.
Grapefruit juice is tasty, sure, but it ain't worth croaking over!