Could a pill one day slow ageing in humans?PunchstockPosted on 07/08/2009 11:37:08 PM PDT by neverdem
Could a pill one day slow ageing in humans?PunchstockRapamycin, a drug commonly used in humans to prevent transplanted organs from being rejected, has been found to extend the lives of mice by up to 14% — even when given to the mice late in life.
In flies and worms, drug treatments have been shown to prolong lifespan, but until now, the only robust way to extend life in mammals has been to heavily restrict diet.
The researchers caution, however, that using this drug to extend the lifespan of humans might be problematic because it suppresses the immune system — potentially making people who take it more susceptible to infectious diseases.
Research teams at three different US institutions — the University of Texas Health Science Center in San Antonio, the University of Michigan in Ann Arbor and the Jackson Laboratory in Bar Harbor, Maine — ran the same experiment in parallel, splitting nearly 2,000 mice between them. The mice were bred to ensure that they were genetically different enough that no single strain would be more or less susceptible to ageing-related diseases or the effects of the drug. They then gave the mice food that included rapamycin.
Problems formulating the feed meant that the teams couldn't start the treatment until the mice were rather older than they had planned — 20 months of age, or the equivalent of about 60 years in human terms.
As it happened, this delay was a fortuitous accident. Compared with the non-drug-taking group, the lifespans of the mice given rapamycin increased by up to 14%, even though they were middle-aged when treatment began. Their life expectancy at 20 months shot up by 28% for the males and 38% for the females.1
"You've probably heard the phrase 'chance favours the prepared mind', and this is an example of it," says David Harrison, who led the arm of the experiment that took place at the Jackson Laboratory.
An independent initiative, the Interventions Testing Program overseen by the US National Institute of Aging, chose rapamycin for the three labs to test because it's known to have effects on a cellular pathway called TOR (for target of rapamycin). This pathway is known from studies in mice, flies and worms to be involved in the age-defying effects of calorie-restricted diets.
“I wouldn't do it myself and wouldn't encourage anyone to do it at this point.”
David Harrison
Jackson Laboratory
This link could mean that rapamycin is mimicking the effects of dietary restriction, says Matt Kaeberlein, whose group at the University of Washington in Seattle works on ageing in mice, yeast and worms. "All the arrows are going in the right direction," he says.
Harrison isn't so sure, however — none of the mice lost body weight during their experiments, he says, and dietary restriction usually works best when started early in life, not in middle age as the rapamycin treatment was.
The big question, of course, is whether this drug could extend human life. Both Harrison and Kaeberlein are cautious. "I wouldn't do it myself and wouldn't encourage anyone to do it at this point," says Harrison.
Getting the dose correct is another problem. A normal human dose of rapamycin is between 2 and 5 milligrams per day, much lower than the dose given to the mice, which was 2.24 milligrams per kilogram of body weight per day.
Perhaps rapamycin could be altered somehow, to reduce its effects in the immune system while keeping its anti-ageing effects? "It's an open question whether you can uncouple that from immune suppression," Kaeberlein says. But in future, he says, it's likely that it will be possible to tweak rapamycin in this way, or to target the other molecules in the pathway instead. Kaeberlein's lab is already working on these downstream targets.
Several other compounds are currently being tested by the three US centres as part of the Interventions Testing Program, including resveratrol, a compound found in red wine and thought to have beneficial effects on the heart, and simvastatin, one of a family of compounds called statins, also used for heart conditions.
For now, the researchers won't be trying out their anti-ageing drug on themselves. But that hasn't stopped them daydreaming about it. "Of course, you can imagine we've been considering it ourselves," laughs Harrison. "I'm 67, so it's just about time for me to start my treatment, isn't it?"
60 Minutes recently did a segment on Resveratrol which is supposed to do the same thing as claimed for Rapamycin here. How about a little cross referencing in these articles & segments in the future?
I see resveratrol is mentioned briefly here, at least.
Similar effects were found in rats given metformin, a widely prescribed blood glucose control drug.
http://www.drugs.com/news/scientists-discover-anti-ageing-metformin-diabetes-drug-3276.html
And here’s a study that suggests that the mechainsm of action of metformin may be the same or similat to rapamycin:
http://groups.google.com/group/sci.life-extension/browse_thread/thread/e10dc658d9b0b0a0
“In flies and worms, drug treatments have been shown to prolong lifespan...”
So you’re saying they’ve been secretly giving this to members of congress?
Most people do not know that Sirolimus(Rapamune) was extracted from the soil of Easter Island in 1987.
I have used Rapamune, since my Heart Tx three years ago.According to my mirror it does not appear to be Ponce de Leon’s fountain of youth.
FReepmail me if you want on or off the diabetes ping list.
Why don't explore some keywords like longevity and mortality? You can check neverdem's posts.
Interesting, our immune system probably helps due us in. We sort of get allergic to ourselves. Cancer is probably related to immubne system as is Altzheimers. So this suppresses immune system.
But may be interesting understanding of how we age.
I’ll try it.
Good lord, it is early. Due should have been do. Typos all over the place. Apologies to all.
Rapamycin is also known to increase the occurance of cancer and things like that.
You’re not really thinking of trying this stuff are you ?
LOL!
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