Posted on 11/22/2023 8:17:37 AM PST by Red Badger
A new study found that (TG), a natural compound in coffee and some vegetables, significantly enhances spatial learning and memory in aged mice. The research indicates that TG modifies key molecular pathways and reduces neuroinflammation, highlighting its potential in addressing age-related cognitive decline.
Recent research has increasingly focused on finding natural compounds that can counteract age-related cognitive decline and promote healthy aging. Trigonelline (TG), a plant alkaloid found in coffee, fenugreek seeds, and radish, has been suggested as a candidate for enhancing cognitive abilities.
In a new study, researchers led by the University of Tsukuba investigated the effects of TG on memory and spatial learning (acquiring, retaining, structuring, and applying information related to the surrounding physical environment) from both a cognitive and molecular biology perspective in an integrated manner using a senescence-accelerated mouse prone 8 (SAMP8) model.
Study Findings
Following oral administration of TG to SAMP8 mice for 30 days, the Morris water maze test indicated a significant improvement in spatial learning and memory performance compared with SAMP8 mice that did not receive TG.
Next, the researchers performed whole-genome transcriptomic analysis of the hippocampus to explore the underlying molecular mechanisms. They found that signaling pathways related to nervous system development, mitochondrial function, ATP synthesis, inflammation, autophagy, and neurotransmitter release were significantly modulated in the TG group.
Molecular Insights and Conclusions
Furthermore, the research team found that TG suppressed neuroinflammation by negatively regulating the signaling factor Traf6-mediated activation of the transcription factor NF-κB.
Additionally, quantitative protein analysis confirmed that the levels of inflammatory cytokines TNF-α and IL-6 were significantly decreased and the levels of neurotransmitters dopamine, noradrenaline, and serotonin were significantly increased in the hippocampus.
These findings suggest the efficacy of TG in preventing and improving age-related spatial learning memory impairment.
Reference:
“Transcriptomics and biochemical evidence of trigonelline ameliorating learning and memory decline in the senescence-accelerated mouse prone 8 (SAMP8) model by suppressing proinflammatory cytokines and elevating neurotransmitter release” by Sharmin Aktar, Farhana Ferdousi, Shinji Kondo, Tamami Kagawa and Hiroko Isoda, 18 September 2023, GeroScience.
DOI: 10.1007/s11357-023-00919-x
This work was supported by DyDo DRINCO and Japan Science and Technology Agency (JST grant number JPMJPF2017).
I didn’t need scientists to tell me that. I figure each cup of strong funnel-brewed coffee (freshly ground) is worth 10-15 IQ points.
I used to know this, but it slipped my mind
always said coffee makes me smartwer...samartur...shmalter, think better.
I’m a huge fan of coffee and radishes: I just need to pick up my fenugreek seed consumption!
can anyone slip some coffee onto the WHouse menu?
someone once said “IF you don’t believe the dead can come back to life just be around any coffee machine in the morning”. every morning there is a miracle in our house.
Just think what you might get if you crossed a jellyfish with a rudabaga
A clear rutabaga that smells like fish................
and call it Prevegy
I feel 2 cups smarter every day.
I knew there was a reason we German/Norwegians from North Dakota drink four to six cups of regular caffeinated coffee every morning.
Drinking decaff is like drinking 3.2 beer.
Does TG keep you up nights?
Hey, I’ve had some of my best blackouts from 3.2 beer. Took around 30 but it is indeed possible.
The cubs gave me a sign for above my pot that reads “Coffee: Because Murder is Wrong”
As long as I can remember where the coffee pot and coffee can be found I should be good to go....
;-)
Finally, proof that I’m the genius I always thought I waz.
I’ll drink to that!...................
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