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A research consortium led by Nestlé Research in Switzerland made a recent discovery that the natural molecule trigonelline present in coffee, fenugreek, and also in the human body, can help to improve muscle health and function. The work builds on a previous collaborative study that described novel mechanisms of human sarcopenia. Sarcopenia is a condition where cellular changes that happen during aging gradually weaken the muscles in the body and lead to accelerated loss of muscle mass and strength and reduced physical independence. One important problem during sarcopenia is that the cellular cofactor NAD+ declines during aging, while mitochondria, the...

A new study found that (TG), a natural compound in coffee and some vegetables, significantly enhances spatial learning and memory in aged mice. The research indicates that TG modifies key molecular pathways and reduces neuroinflammation, highlighting its potential in addressing age-related cognitive decline. Recent research has increasingly focused on finding natural compounds that can counteract age-related cognitive decline and promote healthy aging. Trigonelline (TG), a plant alkaloid found in coffee, fenugreek seeds, and radish, has been suggested as a candidate for enhancing cognitive abilities. In a new study, researchers led by the University of Tsukuba investigated the effects of TG...