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Branded Curcumin Matches Effects of Prozac on Depression
WholeFoods Magazine ^ | 7/24/13 | NA

Posted on 07/28/2013 11:19:21 AM PDT by neverdem

Chester, NJ—A recent clinical trial published in Phytotherapy Research indicated that a high-absorption curcumin (BCM-95 from Dolcas Biotech, based here) had similar effects as a generic form of Prozac (fluoxetine) on depression, sans the adverse effects.

“It is a novel and surprising application for this natural medicine,” said Ajay Goel, Ph.D., Baylor Research Institute and Charles A Sammons Cancer Center, Baylor University Medical Center and study co-author. “People with depression have higher levels of inflammation in the brain. Also, people with depression have lower levels of neurogenesis in the brain, meaning they make fewer new brain cells than people with no history of depression. Curcumin is both a potent anti-inflammatory agent and a powerful stimulator for neurogenesis.”

The three-pronged study included 60 volunteers diagnosed with major depressive disorder, with 20 people taking either BCM-95 Curcumin (500 mg capsules twice daily); 20 people taking fluoxetine 20 mg daily; or 20 people taking a combination of BCM-95 Curcumin twice daily with fluoxetine once daily. Their level of depression was assessed using the clinically validated Hamilton Rating Scale for Depression (HAM-D17), which is used to evaluate one’s mood, feelings of guilt, feelings of suicide and other symptoms.

After six weeks, the research showed that curcumin was well tolerated by all of the subjects. The proportion of responders with improved depression symptoms was higher in the combination group (77.8%) than in the fluoxetine (64.7%) and the curcumin (62.5%) groups. However, the data also showed that BCM-95 Curcumin worked as well as fluoxetine in terms of changes in the HAM-D17 score from baseline through six weeks of treatment.

The study was the first human clinical indication that Curcumin can be used as an effective and safe treatment for patients with depression, though it cannot be considered a medical treatment at this time.

Published in WholeFoods Magazine, October 2013 (online 7/24/13)


TOPICS: Health/Medicine
KEYWORDS: alzheimers; antiinflammatory; bcm95; braininflammation; curcumin; depression; inflammation; prozac; same; tumeric; turmeric
Efficacy and Safety of Curcumin in Major Depressive Disorder: A Randomized Controlled Trial.

Hat tip yefragetuwrabrumuy!

1 posted on 07/28/2013 11:19:21 AM PDT by neverdem
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To: neverdem

Excellent. Believe me, curcumin is good for a million other things too. Everyone should cook with turmeric, and supplementing with capsules would not hurt.


2 posted on 07/28/2013 11:21:18 AM PDT by Yaelle
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To: neverdem

The word on the street is that Curcumin is going to double in price.


3 posted on 07/28/2013 11:22:14 AM PDT by BipolarBob
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To: neverdem

Yeah, sure. Some hippie organic food magazine makes another claim. Remember St. John’s Wort? People who don’t know what real depression is should keep their traps shut.


4 posted on 07/28/2013 11:24:49 AM PDT by ozzymandus
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To: Yaelle

I’m a big believer in tumeric and curcumin. I’m also hearing good things about anatabine (sold as anatabloc). Any thoughts on the latter anybody?


5 posted on 07/28/2013 11:25:22 AM PDT by AtlasStalled
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To: neverdem

It’s an interesting medical condition.

The doctors don’t completely know what causes it — and aren’t quite sure how the medications work.

An unknown cause being treated with guesswork medications.


6 posted on 07/28/2013 11:26:33 AM PDT by BenLurkin (This is not a statement of fact. It is either opinion or satire; or both.)
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To: Yaelle
"Excellent. Believe me, curcumin is good for a million other things too. Everyone should cook with turmeric, and supplementing with capsules would not hurt."

Completely agree.

7 posted on 07/28/2013 11:27:59 AM PDT by blam
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To: neverdem

TAKE TURMERIC CAPSULES!!

you will know you are taking enough when you start to have a craving for ordinary table pepper (instead of salt)

It makes you feel great, and I stopped needing reading glasses


8 posted on 07/28/2013 11:32:19 AM PDT by Mr. K (4 election)
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To: neverdem

There appears to be a peculiar connection somehow, between liver function, mood disorders and cancer. Curcuminoids aid liver function, are beneficial with certain forms of cancer, and are helpful with depression. It’s a powerful natural anti-inflammatory. It also benefits individuals with Alzheimers. Very high dosages have to be administered for therapeutic effect however, and bioavailability is not good at all via the digestive tract.

SAM-e also is helpful with liver function and mood disorders. Bioavailability is not such an issue. It’s even prescribed for liver support over the course of treatments that can pose difficulties with liver function, such as chemotherapy.

What does this mean? No idea. Could be sheer coincidence. Interesting possibilities spring to mind though.


9 posted on 07/28/2013 11:42:35 AM PDT by RegulatorCountry
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To: ozzymandus
People who don’t know what real depression is should keep their traps shut.

This isn't a claim being made by "some hippie organic food magazine." The work behind this article was done by researchers at the Baylor Research Institute of Baylor University Medical School, which is not some fly-by-night outfit. The paper originally appeared in a peer-reviewed scholarly medical journal and the study patients had been diagnosed already with MDD. So, um, yeah, this could be worth paying attention to, as a supplement to prescription anti-depressants if nothing else. Can't hurt.

10 posted on 07/28/2013 11:49:20 AM PDT by ottbmare (the OTTB mare)
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To: ozzymandus

I’ve tried St. John’s Wort. It was superficially helpful, energy levels improved. But over time it began to feel sort of “speedy,” and I experienced anxiety attacks for the first and only time in my life. Also got an odd metallic taste in my mouth.

Turmeric capsules led to a sort of warm pleasant feeling of well-being, fairly immediately. There can be digestive upset from high dosage. Very high dosage can lead to yellowing. I use a fair amount of curry in my food now, so I stopped supplementing. You can feel it in sore joints, they warm up and ache less.

SAM-e was very good. Over a period of weeks I just felt better, very subtle, more energy but not jittery or speedy. It’s a little pricey though. No problems from stopping use of it once I felt better. I’d take it again if the need appeared to be there.


11 posted on 07/28/2013 11:51:22 AM PDT by RegulatorCountry
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To: Mr. K
"TAKE TURMERIC CAPSULES!!"

How much do you take a day?

12 posted on 07/28/2013 11:55:40 AM PDT by blam
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To: ozzymandus; ottbmare

See ottbmare’s comment regarding the particular matter at hand.

However, I’d not be so dismissive about things coming out of Whole Foods: the company has well-heeled superannuated hippies as a target market, but it’s a very well run corporation and its CEO actually proposed real market-based reforms to the health care system that Congress could have adopted and actually made thing better instead of worse by going the statist route with Obamacare. Corporate reputation being hard won, I don’t think they’ll hawk anything unsound in their house publications.

(They’re overpriced, but there are things I buy there when I get to a Whole Foods because you can’t get them at any of our local groceries — e.g. Campo del Montelban cheese, Bulgarian yogurt — along with sale items on which the price
is reasonable, since their product quality is very good.)


13 posted on 07/28/2013 11:59:33 AM PDT by The_Reader_David (And when they behead your own people in the wars which are to come, then you will know...)
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To: neverdem

Great excuse to make curry a part of my regular diet.


14 posted on 07/28/2013 12:00:44 PM PDT by Zhang Fei (Let us pray that peace be now restored to the world and that God will preserve it always.)
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To: RegulatorCountry
Curcuminoids aid liver function, are beneficial with certain forms of cancer

I read an interesting study from a mainstream medical source showing it help slow oral cancer, was being tested on patients leading up to surgery for that.

15 posted on 07/28/2013 12:00:45 PM PDT by ChildOfThe60s (If you can remember the 60s.....you weren't really there)
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To: ChildOfThe60s

It’s very difficult to get sufficient dosage into the bloodstream for therapeutic benefit. Transdermal patches have ben tried, very messy, pronounced yellowing. Sublingual liquid might be helpful being that it was oral cancer. State of the art appears to be liposomal curcuminoids but not certain if even that surmounts the problem of bioavailability.


16 posted on 07/28/2013 12:07:30 PM PDT by RegulatorCountry
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To: RegulatorCountry; ozzymandus

Dried St. John’s Wort is weaker than a fresh plant tincture. But no one responsibly recommends it for serious depressive states. Like the majority of herbal remedies it works best on sub-pathological conditions.


17 posted on 07/28/2013 12:09:09 PM PDT by TigersEye ("No man left behind" is more than an Army Ranger credo it's the character of America.)
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To: TigersEye

I was self-medicating with what I could find, I was without medical coverage and my business was failing, no income, living off of savings. Prayer was the ultimate resolution of my depression. SAM-e was very helpful. Turmeric had some minor, temporary benefit. St. John’s Wort was like a drug, unpleasant with continued useage. It was dried in gelcaps.


18 posted on 07/28/2013 12:13:20 PM PDT by RegulatorCountry
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To: RegulatorCountry
Curcumin had zero therapeutic (antidepressant) effect on me even when taken with Bioperine for good absorption. Certainly notable for other benefits, however.
19 posted on 07/28/2013 12:13:38 PM PDT by steve86 (Acerbic by Nature, not NurtureĀ™)
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To: RegulatorCountry

St. John’s Wort can cause light sensitivity in high doses as well. If it doesn’t provide a benefit at the recommended dose it should just be abandoned not increased. Again, dried St. John’s Wort herb is not the best. My BiL swears by it. I showed him how to tincture his own about 20 yrs ago.


20 posted on 07/28/2013 12:19:09 PM PDT by TigersEye ("No man left behind" is more than an Army Ranger credo it's the character of America.)
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To: ozzymandus

Baylor University study, author is director of epigenetics. Not exactly fruits and nuts.


21 posted on 07/28/2013 1:20:22 PM PDT by heartwood
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To: neverdem

Whole Foods Magazine? Give me The Journal of the American Medical Association or The New England Journal of Medicine for medical advice any day.


22 posted on 07/28/2013 1:29:35 PM PDT by Gay State Conservative (If Obama Had A City It Would Look Like Detroit.)
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To: AtlasStalled

Is one better than the other?


23 posted on 07/28/2013 1:34:38 PM PDT by CaptainK (...please make it stop. Shake a can of pennies at it.)
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To: neverdem

I take Organic India turmeric, about half the “recommended” dose. It has a very noticeable positive effect on my mental processes. Don’t have depression, so cannot comment on that.

Historically, extremely low doses of meds work for me. Higher doses are dangerous.


24 posted on 07/28/2013 1:36:20 PM PDT by Veto! (Opinions freely expressed as advice)
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To: AtlasStalled
I have taken it for chronic pain.

It not only works, but one doesn't risk becoming addicted to other pain-blocking narcotics.

25 posted on 07/28/2013 1:39:59 PM PDT by zerosix (Native Sunflower)
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To: AtlasStalled

It is said to help clear arteries .


26 posted on 07/28/2013 1:43:36 PM PDT by Big Horn (Rebuild the GOP to a conservative party)
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To: RegulatorCountry

As I recall, the patient put curcumin in their mouths, but I can’t remember if the article stated exactly the method. But my impression that it was topically applied to the tissue in the mouth.


27 posted on 07/28/2013 1:51:38 PM PDT by ChildOfThe60s (If you can remember the 60s.....you weren't really there)
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To: neverdem

Heal the sick. Raise the dead. Make little girls talk out of their head....I guess there is no depression in India.


28 posted on 07/28/2013 1:59:22 PM PDT by csmusaret (Will remove Obama-Biden bumperstickers for $10)
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To: ozzymandus

the more exotic the placebo the better... i think there is a faith effect here


29 posted on 07/28/2013 2:00:41 PM PDT by HiTech RedNeck (Whatever promise that God has made, in Jesus it is yes. See my page.)
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To: heartwood

well, talking about depression is like talking about fevers. it’s a catch all for what is probably many different things leading to the same distressing symptom.


30 posted on 07/28/2013 2:01:59 PM PDT by HiTech RedNeck (Whatever promise that God has made, in Jesus it is yes. See my page.)
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To: neverdem
1. God created us with the possibility of having debilitating mental disorders that would cause us to behave in what our religions would declare to be sinful ways.
2. These debilitating conditions include alcoholism, depression leading to self-inflicted wounds or even suicide, anxiety disorders leading to perceived cowardice, epileptic seizures, schizophrenia, etc.
3. We're only now discovering the antidotes to these mental disorders.
4. For centuries people were shunned, excommunicated, burned at the stake, etc. because they were believed to be possessed or demonic or inveterate sinners.
5. Now people have the choice of medicating (rather than praying) their "sins" away or being declared sinful.

This requires some pause for reflection.

31 posted on 07/28/2013 2:05:16 PM PDT by who_would_fardels_bear
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To: BipolarBob
I can't wait until unscrupulous businessmen start packaging all manner of dangerous substances and labeling it curcumin in order to provide a good living for themselves and their families.

Please no one talk about regulating curcumin. The FDA is a bureaucratic hell hole. Businesses have shown time and time again that they can regulate themselves.

Please don't prevent those people who label rat poison as curcumin from giving their sons and daughters the Ferraris they crave.

32 posted on 07/28/2013 2:08:15 PM PDT by who_would_fardels_bear
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To: who_would_fardels_bear
"This requires some pause for reflection. "

Or at least a drink. Or both.

33 posted on 07/28/2013 2:10:20 PM PDT by BipolarBob
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To: who_would_fardels_bear

This sure sounds like a keyhole-viewed, cynical understanding of both medicine and spirituality.

Depression does have a powerful spiritual side. It is a type of self focused hatred. It also is found in many cases to be susceptible to influence (to the worse or to the better) through physical and chemical means.

Talking about depressions as though they were all one illness is like talking about fevers as though they were all one illness.

Yes I plug for a specific faith asserting it identifies a true God. I also know a lot of spiritual rackets or cults make claims about this same God which are palpably false.


34 posted on 07/28/2013 2:11:13 PM PDT by HiTech RedNeck (Whatever promise that God has made, in Jesus it is yes. See my page.)
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To: who_would_fardels_bear

How about cutting out the cutesy hints and evasive barbs and actually stating what you believe is the salient wrong. You add about zero information here.


35 posted on 07/28/2013 2:12:46 PM PDT by HiTech RedNeck (Whatever promise that God has made, in Jesus it is yes. See my page.)
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To: HiTech RedNeck
I don't have the answers, just questions.

I didn't say that all depressions were the same. I made a statement that various mental conditions were viewed for centuries as sinful failures of character or demonic possession.

Do you disagree with that statement?

Do you believe that everyone is capable of overcoming their mental disorders? Even epileptics?

Do you believe that only sinners are the ones that fail to overcome their mental problems and deserve their fate?

Do you believe that everything is right with a world that includes many people that seem unable to deal with their mental conditions?

Certainly people are over-medicating themselves. Certainly there is the possibility that some mental conditions are the result of toxins in the environment, prenatal poisoning from mothers who smoked/drank/took drugs, etc.

But there seem to be many cases where otherwise good and normal people behave in horrible ways until they start taking the appropriate medication.

What do you make of all this? Do you just sing "Onward Christian Soldier" in a louder voice?

36 posted on 07/28/2013 2:34:13 PM PDT by who_would_fardels_bear
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To: who_would_fardels_bear

1) God created a physical universe.

2) God created Adam with free will and put all things physical under his authority.

3) Adam abdicated that authority to Satan and Satan corrupted everything.

Q.E.D. You can’t blame the existence of cancer, tornadoes, bot flies, and entropy on God unless you’re thereby affirming a preference for having been created without a will of your own.


37 posted on 07/28/2013 3:02:35 PM PDT by Eepsy
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To: who_would_fardels_bear
Oh, thank you for these questions.

I could write all night.

Demonic possession, when it was thought to have happened, was not considered a fault of the, ah, possessee — unless s/he had called on the demon.

For around 500 years the normal Catholic official wisdom about possession was that one should only conclude that when medical reasons had been ruled out. The failures were in the undeveloped natural philosophies. The theoretical/theological side was pretty much in order.

However, it IS true that there remain some superstitious jerks among Christians.

I would not say that ALL “defects of will” can be medicated away. For example, you're the second person I've encountered today who has based some negative opinions about the Church on ignorance of what the Church officially teaches and prescribes. I don't think there is yet a medicine to address basing judgments on what amounts to poorly substantiated or unsubstantiated rumor.

I WILL say this about the generosity and compassion of the modern scientists dubious about theism generally and Christians specifically:

When my kid was 15 months old, I was told she would die a slow and lingering death as a destructive epilepsy trashed her brain. (At least some of the scientists were wrong on that one. She turns 30 this November.)

At the time I was an Episcopal priest. (I am now a Catholic lay-D00d.) We had recourse to the local pediatric neurology gods, among whom was a certain Dr. Dreyfus. The usual routine was that he would schedule an appointment right slap in the middle of nap time. Then he would be 45 minutes late. Then, when my kid cried as he examined her, he would call her “spoiled.”

So,one day I showed up with my kid, and I had come from “work” so I was wearing my “clericals” (black suit and shirt, backwards collar.) This meant that I got to listen to how Christians in the middle ages thought epilepsy was demonic and were just SEW superstitious and all.

While my kid was, according to him, dying.

I'm sure there is some good, scientific, anti-church explanation about why, when a father's only child is dying it is good to call him a jerk.

38 posted on 07/28/2013 5:27:12 PM PDT by Mad Dawg (In te, Domine, speravi: non confundar in aeternum.)
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To: Gay State Conservative

Yeah, those journals, bought and paid for by Big Pharma, are really helpful....if all you do for your health is continue courses of Big Pharma drugs! You know, the kind with the list of side effects 3-4 pages long?


39 posted on 07/28/2013 7:37:09 PM PDT by EarlT357
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To: who_would_fardels_bear

Hey, the Luke who wrote the gospel and Acts was also a physician and did not stop being one when he became a believer in Jesus. Folks who say doctors have no place in Christian ministry are just being silly.

Well, how about looking at my own freep page. I don’t think you will read that as just a louder version of “Onward Christian Soldiers” (as helpful as that hymn can be in the appropriate circumstance, it is not a comprehensive gospel message).


40 posted on 07/28/2013 8:10:40 PM PDT by HiTech RedNeck (Whatever promise that God has made, in Jesus it is yes. See my page.)
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To: Eepsy

More or less... there are some disputes over details but that’s the general thrust of the fall of the creation. The old earth and young earth creation theological camps probably won’t see eye to eye anytime sooner than the return of the Lord, but both perceive a metaphysical shift, rooted in a spiritual shift, that came with men accepting the sin of the rebellious angels. And one important point to note, as in the case of the man born blind that Jesus healed, is that not all suffering is due to one’s own personal sins. It is part of being in a battle zone.


41 posted on 07/28/2013 8:18:31 PM PDT by HiTech RedNeck (Whatever promise that God has made, in Jesus it is yes. See my page.)
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To: who_would_fardels_bear

Hopefully others have presented better answers than I have furnished. But I think to sum up, yep we are in a spiritual war zone. God folds suffering into His plan in an omniscient, omnipotent manner to, among other things, show people the need of returning to God even while refraining from forcing their will. Really, to some people God could never do anything to satisfy them. If God forced their wills then they’d call God a manipulative tyrant. If God refrains then they’d accuse God of being vague and difficult. Now if you take this as an accusation to sufferers that they have somehow earned their suffering through sinning, you have warped my message. Because mercy is also folded into His plan.


42 posted on 07/28/2013 8:26:12 PM PDT by HiTech RedNeck (Whatever promise that God has made, in Jesus it is yes. See my page.)
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To: Mad Dawg

Well Dawg, you got to see what happens when scientific pursuit worships itself and forgets the roots it once had in the pursuit of the divine. We can have valid arguments over “HOW” God did something, but not over “WHETHER” God did something, unless we want to try to wrench ourselves artificially out of the hands of God.


43 posted on 07/28/2013 8:32:10 PM PDT by HiTech RedNeck (Whatever promise that God has made, in Jesus it is yes. See my page.)
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To: EarlT357
“Big Phrama”? You signed up *today* to tell us about “Big Pharma”? Please let us know when a member of your family is diagnosed with,say,advanced brain cancer.He/she will surely,at your insistence,choose infusions of liquefied alfalfa sprouts instead of any of the poisons produced by “Big Pharma”.
44 posted on 07/28/2013 8:35:31 PM PDT by Gay State Conservative (If Obama Had A City It Would Look Like Detroit.)
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To: Gay State Conservative

ah, ignore the heckling trolls who have nothing but negative comments and nothing constructive to offer.


45 posted on 07/28/2013 8:41:52 PM PDT by HiTech RedNeck (Whatever promise that God has made, in Jesus it is yes. See my page.)
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To: HiTech RedNeck
I suppose you’re right.
46 posted on 07/28/2013 8:48:11 PM PDT by Gay State Conservative (If Obama Had A City It Would Look Like Detroit.)
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To: Gay State Conservative

They’re trying to trap your mind in a cage of surmises, without being challenged on their surmises. It is so easy to damn the good because it isn’t perfect and that’s an infantile, sinful game. It’s not as easy to figure out how to make the good better.


47 posted on 07/28/2013 8:50:23 PM PDT by HiTech RedNeck (Whatever promise that God has made, in Jesus it is yes. See my page.)
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To: HiTech RedNeck
the more exotic the placebo the better... i think there is a faith effect here

Frankly I don't care if it's "just a placebo" I want the pain to go away.

48 posted on 07/28/2013 11:33:43 PM PDT by null and void (You don't know what "cutting edge" means till you insult Mohammed.)
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To: HiTech RedNeck

Oh, that’s a massive huge 10-4 with whipped cream AND sprinkles!

Scientism is clearly a false religion as can be shown by the inductive process. In particular it weakens the mind. The unawareness that what a thing IS might be importantly different from what it is MADE OF, or that how a thing comes to be might be different from why or to what purpose it came to be ... this kind of unawareness is just sloppy. But it’s a sloppiness Scientism fosters.


49 posted on 07/29/2013 6:15:09 AM PDT by Mad Dawg (In te, Domine, speravi: non confundar in aeternum.)
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To: neverdem

The problem is that curcumin is not well absorbed.The only way I know of to enhance this is piperine, which is why I eat pepper before taking it.


50 posted on 07/29/2013 12:17:42 PM PDT by rmlew ("Mosques are our barracks, minarets our bayonets, domes our helmets, the believers our soldiers.")
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