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A Cure For Diabetes: Medicine's Next Big Thing?
ivanhoe.com ^ | 10/11/10 | Ivanhoe News

Posted on 10/11/2010 8:51:51 PM PDT by Pining_4_TX

Now, for the first time, researchers are using diabetes and "cure" in the same sentence.

Doctor Donald Jump at Oregon State University eliminated diet-induced diabetes -- or type two diabetes -- in lab mice.

"We saw that certain enzymes were being repressed by the high-fat diet," Donald Jump, Ph.D., department of nutrition and exercise sciences, said.

The enzyme he's talking about is called fatty acid elongase-five. The more fat we eat, the less of the enzyme we produce. So, when researchers boosted the production of the enzyme in mice livers, they were cured of their diabetes in five days.

"The animals’ hyperglycemia disappeared, and their fatty liver disappeared, and their insulin resistance disappeared. We were very dazzled by this outcome," Dr. Jump added.

(Excerpt) Read more at ivanhoe.com ...


TOPICS: Health/Medicine
KEYWORDS: diabetes; diet; fat; fattyliver; health; liver; mice; mouse; obesity
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Yes, I know this is in the very early stages, and so far mice are the only beneficiaries, but I post these items for people who are interested in the latest research on diabetes. I do not intend to give anyone false hope.
1 posted on 10/11/2010 8:51:55 PM PDT by Pining_4_TX
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To: neverdem; HuntsvilleTxVeteran; Walkingfeather

ping


2 posted on 10/11/2010 8:52:49 PM PDT by Pining_4_TX
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To: Pining_4_TX
Thanks for the ping and information.
3 posted on 10/11/2010 8:55:39 PM PDT by HuntsvilleTxVeteran ((B.?) Hussein (Obama?Soetoro?Dunham?) Change America Will Die From.)
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To: Pining_4_TX

Well....maybe that’s why when I eat more fat and protein I feel better....and I’m NOT hungry.....diabetes runs in my family (Type 2) and I think it’s related to eating too many carbs, not enough fat/protein....some people just don’t need so many carbs....


4 posted on 10/11/2010 8:56:05 PM PDT by goodnesswins (f you don't support Obama, and the deconstruction of America: YOU are a RACIST.)
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To: Pining_4_TX

follow the atkins diet. It too has the same effect on type 2 diabetes.


5 posted on 10/11/2010 8:56:05 PM PDT by wombtotomb
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To: Pining_4_TX

You might state clearly that this is another potential treatment for TYPE II or adult-onset diabetes not insulin-dependent Type I diabetes.

The kind of diabetes you give yourself from being morbidly obese. Hint, try losing the weight first and see if that doesn’t clear things up.


6 posted on 10/11/2010 9:01:16 PM PDT by sinanju
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To: goodnesswins; wombtotomb

It’s bee said by some nutritional gurus that our obesity epidemic has a lot to do with the “low-fat” craze. Human beings need “good fats” in their diet. Without it, we just stuff ourselves with low-quality carbs and turn into plumpers.


7 posted on 10/11/2010 9:03:33 PM PDT by sinanju
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To: goodnesswins
The suggestion here is that when the mice eat more fat they feel better too because that suppresses the production of an enzyme that would otherwise keep their blood sugar down. The mice are probably pole vaulting around their cages!

I feel better when I use insulin because it lowers my blood sugar ~ which simply goes off the charts if I don't use insulin. (This is that inbetween 1 and 2 deal where you get to suffer the symptoms of both ~ obviously an immunological disease)

Still, this makes sense ~ a missing enzyme causes problems. Think about it in a state of nature. You are out there eating wild game and berries. You have little or no starch or sugar in your diet. That's gotta' drop your blood sugar below normal UNLESS, perhaps, the body suppresses production of that enzyme.

Later, in Summer, when there's plenty of sugar around, you eat less game, sit around the camp and grow fat and lazy, and the enzyme comes back to control your blood sugar levels.

8 posted on 10/11/2010 9:04:19 PM PDT by muawiyah ("GIT OUT THE WAY" The Republicans are coming)
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To: sinanju
The weight is a symptom, not a cause. If this enzyme has a seasonal element in it the answer is to change your diet a couple of times a year and just pig out on what's appropriate.

Meat in winter; taters in the summer!

9 posted on 10/11/2010 9:06:31 PM PDT by muawiyah ("GIT OUT THE WAY" The Republicans are coming)
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To: Pining_4_TX
There has been too much smoke around the diabetes problem, for there not to be some fire. If something like this pans out it will do more to reduce healthcare costs than any bill out of congress.
10 posted on 10/11/2010 9:10:19 PM PDT by hinckley buzzard
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To: Pining_4_TX

Many people are cured of type two diabetes with gastric bypass. It occurs as quickly as the next day. There is a theory about cutting the gastric mucosa.


11 posted on 10/11/2010 9:10:31 PM PDT by Chickensoup (There is a group of people who suck off the productive. They make rules then find infractions.)
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To: Pining_4_TX

alpha lipoic acid, trivalent chromium, and vanadium sulfate are dirt cheap over the counter natural substances that are very effective for type2 diabetes.


12 posted on 10/11/2010 9:12:50 PM PDT by devere
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To: goodnesswins

this article is unclear....it almost seems like too much fat in our diets is suppressing the good enzyme...anyone else readaing it that way..


13 posted on 10/11/2010 9:23:20 PM PDT by cherry
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To: Pining_4_TX

It will never happen. If diseases get cured no one makes money. There will be new “treatments” of course...


14 posted on 10/11/2010 9:32:49 PM PDT by ColdSteelTalon (Light is fading to shadow, and casting its shroud over all we have known...)
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To: devere

It would seem that the researcher has found a method of manually switching back to the “low fat” or “normal” gene expression state. T2 diabetes is multifactorial and the other causal factors will not be corrected by this process.
Another problem would be that the T2 diabetic would need to alter his food consumption patterns to protect the newly corrected state. Many T2 diabetics would maintain their carbohydrate heavy consumption patterns because they need the higher levels of glucose and insulin in order to achieve their desired serotonin levels.


15 posted on 10/11/2010 9:34:24 PM PDT by kruss3 (Kruss3@gmail.com)
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To: Chickensoup

A bariatric doc once told me that gastric bypass is the only known “cure” for Type 2 Diabetes. I believe that the hormone grehlin is the culprit in Type 2 DM.


16 posted on 10/11/2010 9:37:09 PM PDT by Born Conservative ("I'm a fan of disruptors" - Nancy Pelosi)
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To: Pining_4_TX
The enzyme he's talking about is called fatty acid elongase-five. The more fat we eat, the less of the enzyme we produce. So, when researchers boosted the production of the enzyme in mice livers, they were cured of their diabetes in five days.

Not sure how everyone has concluded that a low fat diet is the problem. The article says the more fat we eat, the less of the enzyme is produced. And the Type II diabetes was cured in mice by boosting production of the enzyme.

They don't say how they boosted production of enzyme. It might be that essential fatty acids in the diet boosted production, but they don't say. It's not clear whether all fats suppress production of the enzyme.

"We saw that certain enzymes were being repressed by the high-fat diet," Donald Jump, Ph.D., department of nutrition and exercise sciences, said.

17 posted on 10/11/2010 9:39:25 PM PDT by Will88
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To: Pining_4_TX

More information about the study here:

http://oregonstate.edu/ua/ncs/archives/2010/jul/discovery-points-new-approach-diabetes-therapy


18 posted on 10/11/2010 9:45:22 PM PDT by The King of Elflands Daughter
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To: Pining_4_TX; All

Very interesting!

I just did a search and found this:

Mice Essentially ‘Cured’ of Mild Diabetes With Enzyme

http://www.sciencedaily.com/releases/2010/07/100712141849.htm

where the interesting part, to be researched further, is:

“There are already drugs on the market, such as some fibrate drugs, that induce higher levels of elongase-5 to some extent.”


19 posted on 10/11/2010 9:47:22 PM PDT by SmartInsight (Bad officials are elected by good citizens who do not vote. ~ G. J. Nathan)
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To: SmartInsight

But caution is advised, it seems fibrate drugs lower triglycerides, but increase homocystein.

http://healthlibrary.epnet.com/GetContent.aspx?token=e0498803-7f62-4563-8d47-5fe33da65dd4&chunkiid=21669


20 posted on 10/11/2010 9:50:09 PM PDT by SmartInsight (Bad officials are elected by good citizens who do not vote. ~ G. J. Nathan)
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