Posted on 07/17/2014 6:13:02 AM PDT by Innovative
When mice with the human equivalent of Type 2 diabetes were injected with the protein FGF1, their blood sugar levels returned to normal over two days. Just one injection of the protein both regulated these levels and even helped reverse insulin insensitivity – the underlying cause of diabetes.
Published in the journal Nature, the research on FGF1 could revolutionize diabetes treatment.
In addition to being effective against diabetes, the protein has several advantages over current diabetes drugs. It does not result in dangerous side effects seen with other diabetes drugs, such as heart problems, weight gain, or hypoglycemia. Additionally, FGF1 not only increased insulin levels but also helped the mice regain their own ability to regulate insulin.
(Excerpt) Read more at foxnews.com ...
Thanks for the link.
http://www.prospecbio.com/FGF-1_Human_2_15/?gclid=CLL9_4y8zL8CFUEF7AodpXcAzA
It doesn’t look like they are restricting who can purchase it and it’s not even very expensive, given that one dose could provide full cure.
I think what we need to find out is what is the equivalent dose for humans and how could we administer it — as in diluting in something for injection.
The researchers are using a single factor rodent diabetes knock-out model that in no way resembles the multifactorial human diabetes condition. The injected FGF1 protein simply restores the knocked-out gene function and the non-diabetic status in the now “non-knocked-out” rodent. This is a play toy that allows researchers to explore interesting secondary gene functions related to the diabetes condition. It has no implications for resolving diabetes in humans.
FWIW, I’m pre-diabetic with some insulin resistance. I got it honestly from my father who was type II, and I’m trying to avoid any pharmaceuticals, using supplements and acupuncture among other options to keep it from worsening. FGF1, as far as I can tell, affects the cell wall, which is where insulin resistance occurs, so at least it makes logical sense, though of course the body is more often counter-intuitive, and mice are not always a perfect analogue for humans.
Whatever anyone here can find out, I would be interesting in participating in.
Here is the abstract of the article in Nature — to access the full article, one has to subscribe.
Endocrinization of FGF1 produces a neomorphic and potent insulin sensitizer
http://www.nature.com/nature/journal/vaop/ncurrent/full/nature13540.html
Fibroblast growth factor 1 (FGF1) is an autocrine/paracrine regulator whose binding to heparan sulphate proteoglycans effectively precludes its circulation1, 2. Although FGF1 is known as a mitogenic factor, FGF1 knockout mice develop insulin resistance when stressed by a high-fat diet, suggesting a potential role in nutrient homeostasis3, 4. Here we show that parenteral delivery of a single dose of recombinant FGF1 (rFGF1) results in potent, insulin-dependent lowering of glucose levels in diabetic mice that is dose-dependent but does not lead to hypoglycaemia. Chronic pharmacological treatment with rFGF1 increases insulin-dependent glucose uptake in skeletal muscle and suppresses the hepatic production of glucose to achieve whole-body insulin sensitization. The sustained glucose lowering and insulin sensitization attributed to rFGF1 are not accompanied by the side effects of weight gain, liver steatosis and bone loss associated with current insulin-sensitizing therapies. We also show that the glucose-lowering activity of FGF1 can be dissociated from its mitogenic activity and is mediated predominantly via FGF receptor 1 signalling. Thus we have uncovered an unexpected, neomorphic insulin-sensitizing action for exogenous non-mitogenic human FGF1 with therapeutic potential for the treatment of insulin resistance and type 2 diabetes.
Exactly right. My family has a great deal of diabetes in the family and none of them are overweight. One has Type 1 and he’s 6 ft, 145 pounds, low weight probably because of the diabetes. But don’t argue with the holier than thou. It’s always a lifestyle choice according to them.
Is there any particular food that contains FGF1?
I agree with you and others who have said the same - symptoms do not equal causality. If it were diet & exercise issue, then more half of American adults would be diabetic.
The snag is in the last paragraph of the article. They need to find a variant that doesn’t also affect cell growth. IOW, if I understand correctly, a variant that’s not carcinogenic.
Somebody tell me if I’m misunderstanding.
My dad’s side of the family had to deal with this one generation after another.
As soon as the FDA approves it.
Usually only takes fifteen or twenty years.
It is a major event; however, I hope Smiling Bob is not involved in any way.
Much appreciate the ping
A single injection of FGF1 is not going to cure diabetes in humans. A thousand injections of FGF1 are not going to cure diabetes in a human. Diabetic humans are not the same creatures as rodent diabetic knock-outs.
Or you can just go to the health food store or online and buy Alpiste (Canary Seed) and mix with water and drink twice daily. Totally organic, no side effects, high protein, flushes fat and lowers blood sugar naturally. We drink it everyday.
Does the seed stay whole or do you grind it up first?
Well you can buy the seeds then there is a process of soaking and grinding which is pretty simplistic or you can just buy the powder which is already prepared and mix it with water. Either one is about as effective as far as I can tell. We do both.
A lot of people who start drinking the canary seed milk get off the Type II Diabetes drungs after a few months. We have lost a good deal of weight already.
Great,
Thank you, will give this a go. :)
Just google canary seed milk online and you can read all about it.
No such thing as Big Pharma. If one company can bring a drug that will run its competitors out of the market they will. If another company can make something similar, they will claim their version is superior and try to take all the business from the first company.
No different than Big Electronics or Big Deodorent.
Big Electronics is always coming up with shocking current innovations that charge the economy, but Big Deodorant is just the pits.
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