Yes, it's the YECs against the world, and it's not just in biology. The YECs have trouble with the rest of the world's geology, astronomy, paleontology, cosmology, nuclear chemistry (so far as it supports an old universe), etc. One need only look at the list of issues presented in 1375. None of its points address anything Darwin ever said or thought in his life or much of anything in biology.
There is no astounding discovery to rescue the YECs from this hopeless position. Something that overturns all of biology won't do it. Something that overturns all of astronomy won't do it. Something that revolutionizes cosmology won't do it. Something that revolutionizes geology won't do it.
They have to pull the impossible revolution in biology, then they have to do it in geology, then they have to do it in astronomy, then they have to do it in nuclear chemistry, then they have to do it in cosmology ...