As a person who loads and carries many calibers, I think these statements do not bear out with ER statistics. A .380 Hydrashock, etc. can be a deadly round. I do not weigh 300 pounds. I cannot conceal my .45 Colt Combat Commander MKII in the Summertime. I carry a .380 simply because I cannot conceal the Sig 226, either.
I think comments like that are best reserved to the useless and annoying .25ACP. They neglect that fact that in many places, if used in self-defense, you WILL use it at powder burn range, or you will go down for murder.
The 22/25 are a compromise in carry package, certainly not in caliber choice. The 25 starts to come into a better cartridge, but only with specialized ammo....Glasers. The 380 is an ok cartridge, but if you are looking at a package that small, there are many good 38 Special revolvers in the same size and even less weight with Titanium available. And you get a more effective cartridge.