What he couldn't foresee in all his adventures was the beginning of Islam several decades after his death, which came on like a supernova, and which no one was prepared to contain. I'm not sure that it could have been withstood past the fallback lines in Asia Minor due to terrain, logistical and communications issues, but I'd like to think that Syria, Lebanon, Israel and egypt could have held longer and wound up differently (those were predominantly ethnically Greek with some local mixing at that point in time). Anyway, considering how long the line held in Asia Minor, they didn't do that badly.