I regularly shoot my .454 Casull at the range. The .454 Casull has an equal amount of recoil as a .300 Ultra Magnum Rifle. My revolver is ported and has a nice set of grips which makes shooting it bearable.
I do not have any concrete information on the recoil of this new .500 S&W but my guess is that it will be untolerable for the vast majority of shooters. Here is a link to a chart showing handgun recoil for various calibers.
Chuck Hawk's recoil table
The .500 Linebaugh is towards the bottom of the page. I can only assume that this .500 S&W is based on the .500 Linebaugh cartridge so it may be comparable with these figures.
Thanks for that table .... based on it I think I'd handle the 500 with no problems :)
Just recently finished a batch of 260 grain bullets at 2000 fps (37gr H110) .... and realized it wasn't enough .... shoots nice one handed though :)