The Shuttle was in a 57 degree left bank (as part of its entry flight attitude procedures known as the Roll Schedule, I am given to understand), meaning it was rolled along its center line axis with left wing low, and right wing high.
A staggered series of sensor failures and reading anomalies occurred; sensors intended to measure the temperature of the airframe (not the surface of the airframe) indicated 45 degrees higher on the left than right, sides.
There was indication of a left elevon above normal which caused the Shuttle to roll further to the left.
The Shuttle autopilot attempted a corrective roll to the right.
Thereabouts in the timeline, the temperature and pressure sensors for the left in-board and left out-board main landing gear tires, quit, ie. as they say, "went off-scale low."
That prompted the Shuttle's computers to alert the flight crew. Mission Control asked the crew if they saw the message on their displays. The Shuttle Commander began a response, promptly interrupted by we don't know what ... near the top of the hour.
And we do not yet know what initially caused the deterioration of the left wing.