Regarding the ISS, the three astronauts should be evacuated at the earliest possible time and the project abandoned. A possible followup project would be use of the ISS as a laser weapon target, thereby providing a means whereby earth-based mass spectrometers can be precisely calibrated as aluminum, titanium and other alloys are vaporized in the vacuum of space.
Not in space, GETTING THERE. ROUTINELY. The big nut to crack is getting there, not staying there. Look at the material science that has been developed with Shuttle. Jeez.