You admitted, with your 42 million, that this would be one change fixing itself in the entire human genome every three months- and that was in FUNCTIONING GENES THAT ARE EXPRESSED! This does not seem realistic at all.No, 1 fixation every 3 months was for all types of mutation:
Let's see... 10 million years divided by 42 million mutations = 1 fixation every .238 years (3 months or so). But keep in mind that there are always many mutations at different locations in the genome working in parallel to get themselves fixed at the same time. How many? I have no idea, but if there were 1000 different alleles out there in the population at the same time that would mean an average allele would have 238 years in which to fixate for the numbers to work out. If there are 100,000 alleles then the average allele has 23,800 years to acheive fixation for the numbers to work out.
10 million years / 1.26 million coding base pair differences = 1 coding fixation every 8 years. Then multiply that by how many coding differences are working towards fixation at any one time. 10 mutations simultaneously working their way means each mutation has 80 years available to fixate, 100 mutations = 800 years per mutation, etc.
I went to that link you gave to g3K. Here, from your link are two examples of a LACK of gene change that I found very interesting....Which link is that? Could you provide the url? I couldn't find any reference to cheetahs at the Hardy-Weinberg page from Kimball.Cheetahs, the fastest of the land animals, seem to have passed through a similar period of small population size with its accompanying genetic drift. Examination of 52 different loci has failed to reveal any polymorphisms; that is, these animals are homozygous at all 52 loci.
That's an interesting finding, but I want to see more information about how exactly they were comparing these 52 loci. Were they using gel electrophoresis, or did they do actual letter-by-letter sequencing of 52 genes? It doesn't seem too surprising that an inbred population would all look the same if you don't sequence the DNA letter by letter. IOW, I think there are lots of sequence differences among cheetahs that are under the radar of that study - cheetahs are not all exact clones of each other.
Here's something interesting I found at another cheetah page:
There are seven recognized subspecies of cheetah, distinguished by subtle differences in their coats. The most striking is the king cheetah with spots that have been modified into wide discontinuous bars.
How can there be 7 recognizable subspecies if they're all exactly the same? (aHA!)
Also on that page, it describes the cheetah's habits. It seems they're very mobile - in fact cheetahs can't be housebroken because they don't stay in one place in the wild, so they have no real "home territory" to keep clean. I suspect that African cheetahs (the only population that survived after the bottleneck 10,000 ya) were one of those species I described to g3k, where they were one big population instead of tribes that were securely isolated over time. So maybe cheetahs are an example of Hardy-Weinberg forcing stasis. (Unlike humans & chimps, who both stayed in relatively small, isolated groups where gene drift could work.)
http://users.rcn.com/jkimball.ma.ultranet/BiologyPages/P/Polymorphisms.html#GeneticDrift
Condorman, I will take any credit you are willing to give. I am glad to hear that you do want to move forward with a mathematical model. The mouse thing was meant to be a tight analogy with our discussion of evolution vs. intellignet design. I was only trying to show that it is not necessary to reproduce the Creator in a laboratory in order to infer that non-random forces had been at work.
Since you have said that I misinterpreted and you DO think this thought experiment of ours has some value, it does not matter about the analogy. (Also as an aside, I thought the very same thing. Where could such critters prosper? Perhaps in the block crawl space under my house, where they could attract bugs to eat and no large predators can enter (well, maybe a snake.))
So I am being very generous here- whenever the numbers are in doubt, I am conceding the numbers to you two. Whenever there is doubt about how much of the genome is functional (i.e. is 'junk DNA really 'junk'', I think most of it is not, you think it is) I am conceding it to you. I am bending every step of the way and using your own numbers at every point.
So here it is : we are agreed that the minimum differences in mutations would require one fixation in the population's overall genome every three months, with one fixation in the coding regions every 8 years? Yea or Nay?