Not in a 50-49-1 Senate, or even the Senate as it's constituted today.
Moderate Republicans vote with Democrats ALL THE TIME.
Nickles won't compromise with them, you're right, which is why he will never be elected Majority Leader.
Frist will have to be more moderate than you think.
The idea that a Republican-controlled Senate is going to operate like a Republican-controlled House is a fairy tale. It never has, and it never will, no matter who the Leader is.
Bush cant really win with a Republican Senate, because they will compromise in a direction AWAY from the President. If the Senate were held by Dems, then the compromise is TOWARDS the Presidents position.
I think Karl Rove understands this, and couldnt care less if we lose the Senate over Trent Lott. The only exception to this, is on Judicial appointments, but Bush should have made recess appointments anyway.