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To: AndrewC
You would compare the spell-checker routines and not the text compare subroutines alone. I haven't suggested that the entire genomes of the bugs be compared when trying to establish the connection between two proteins. Compare the complete proteins.

No, because you already know in advance that they differ in ways that are going to affect the results. ExbB codes for three membrane segments, motA codes for four. Right off the bat that's going to skew the percentage of correspondences in a way that really isn't particularly revealing or useful.

Essentially, you're putting two different fruit baskets side by side and trying to compare them. You're much better off if you break them down into their smallest functional subunits, and then compare those. That way, you can pull out an apple from each basket and compare them directly, rather than comparing the bunch and watching the correspondences get lost in the noise created by the fact that one basket has a banana where the other has a pear, and the second has two oranges where the first has none. Apples to apples ;)

1,117 posted on 12/05/2002 8:07:42 PM PST by general_re
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To: general_re
No, because you already know in advance that they differ in ways that are going to affect the results... Right off the bat that's going to skew the percentage of correspondences in a way that really isn't particularly revealing or useful.

What? That is the purpose of measuring. Then an exact correspondance of the functional part means they are the same.

Apples to Apples and Fruit baskets to fruit baskets.

1,119 posted on 12/05/2002 11:59:08 PM PST by AndrewC
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