When they are not afraid of man they will treat people as prey. The old russian stories of siberian wolf packs chasing sleighs is no joke. They did.
On the other hand they learn fast. Shoot a few wolves and the packs learn to avoid man. The the older wolves teach the younger wolves. But they are smart - they avoid people with guns, not necessarily people without guns. They have very, very good noses - they can smell the gun oil and even the metal.
As long as we have people shooting wolves occasionally they will remain cautious and the number of wolf attacks on people will be low. But if we act like we are in a Bambi movie, eventually we will have pack attacks on hikers or campers.