[Carlucci]

I heard somewhere that "I am God" is a difficulty setting on a video game, maybe a first-person shooter like "Duke Nuke'm" or "Wolfenstein".

Can anyone confirm this?

[Shooter 2.5]

There is a "God" setting on most computer games. It's not a "I am God" setting. It's basically an invulnerable mode which also gives you all of the supplies and/or ammo necessary to explore the game without having to worry about being stopped by adversaries.
It's popular with gamers who borrowed the game for a short time and they just want to explore the areas within the game or for gamers who get stuck at a level and can't finish.

[Elenya]

I heard somewhere that "I am God" is a difficulty setting on a video game, maybe a first-person shooter like "Duke Nuke'm" or "Wolfenstein".

Correct. God is also a very common name for video and online game players. Also the name of the sniper in the Navy Seals movie.

For another "domestic" explanation of the note, see my post #117.

[LurkedLongEnough]

"I am God" is a difficulty setting on a video game

Black & White comes to mind. The product link reads "Be good. Be evil. Be a god."