Judge Roy Bean once described as suicide a man who went up against a long gun with a handgun. However, I would take the shot and hopefully get a few rounds of .45 cal lead into the sniper before he could adjust his aim onto me, presuming I stumbled onto him. A few rounds of .45 acp lodged in his torso may just disturb his subsequent aim.
Stay well - Stay safe - Stay armed - Yorktown
loss of judgement and motor skills are the first signs of lead poisoning. If you stumbled on them in their "nest" you would have a pretty good chance.
Just remember to plug their new holes with bacon.