No, they are just friends according to my 14 year old son who watches the show daily and nightly, permently. He is not gay either. It is a pretty funny show. If naughtical nonsense be something you wish, drop on the floor and flop like a fish. SPONGEBOB SQUAREPANTS!!!!!
There was when John K. left Ren & Stimpy (the episodes were worse). There were also some stylistic differences when John K. left Ralph Bakshi's Mighty Mouse but it was on a seasonal change and the staff may have just reformulated the concept a little (that second season was actually better than the first, they really hit their stride).
I can still watch a cartoon but Hanna-Barbera did too many Ren & Stimpy knock offs in the 1990s. Only a few anime shows in the whole history appeal to me (I haven't caught the American release of Lupin the Third yet). Some things like Adult-Swim try to be "weird". I'd rather have good than weird, anyday.