Not in the Nuclear world. When the spec sez hardwired IO, they mean banks of mechanical relays and 48 volt signals. The popular controller is an old fashioned PLC. Digital anything is only for non safety related circuits.
I'll buy that in the nuke world, but in avionics it's digital everything. The only analog stuff is the old 8 day clock and the standby instruments that alot of pilots don't even remember how to fly (or that they got spoiled in flight training and didn't really learn how to fly them).