Posted on 08/03/2002 7:46:10 AM PDT by madfly
Edited on 08/03/2002 7:57:30 AM PDT by Admin Moderator. [history]
by Sherri Tenpenny, DO
Published 07. 15. 02 at 4:03 Sierra Time
“We interrupt the current programming to bring you this important news update…there has been a reported case of smallpox in Washington, D.C…”
What will happen next? Pandemonium. The press has done its job over the last few months reinforcing the belief that an epidemic is about to occur, potentially causing millions of deaths. Americans thousands of miles from Washington will demand the smallpox vaccine, a vaccine with the highest risk of complications of any vaccine ever manufactured and with a dubious track record for success.
However, because you are informed, you will have a different response. You will not panic. You will turn off the TV. You won’t listen to your hysterical neighbors. And more importantly, you won’t rush to be vaccinated. Here’s why:
On June 20, 2002, I attended the Center for Disease Control’s (CDC) meeting of the Advisory Committee for Immunization Practices (ACIP) and listened to one and a half days of testimony prior to posting the recommendations for smallpox vaccination that are currently being considered by the CDC and the Department of Health and Human Services (DHHS.) Many testimonies and comments were presented by public participants and by various physicians and researchers associated with the CDC. Noting that two weeks have past since the June 20th meeting and the media has still not reported on this historic event, I decided it was imperative to report the content and outcome of this meeting to the general public. After reading this report you will gain a new perspective on smallpox and, hopefully, in the event of an outbreak, you will understand that you have nothing to fear.
Generally accepted facts
Nearly every article or news headliner regarding smallpox is designed to instill and continually reinforce fear in the minds of the general public. Apparently the goal is to make everyone demand the vaccine as soon as it is available and/or in the event of an outbreak. A very similar media campaign was developed prior to the release of the Salk polio vaccine in 1955. The polio vaccine had been in development for more than a year prior to its release and was an untested “investigational new drug,” just as the smallpox vaccine will be. The difference is that the potential side effects and complications of the smallpox vaccine are already known, and they are extensive.
Generally accepted facts about smallpox include:
1. Smallpox is highly contagious and could spread rapidly, killing millions
2. Smallpox can be spread by casual contact with an infected person
3. The death rate from smallpox is thought to be 30%.
4. There is no treatment for smallpox
5. The smallpox vaccine will protect a person from getting the disease
AS IT TURNS OUT, THESE "ACCEPTED FACTS" ARE NOT THE "REAL FACTS."
Myth 1: Smallpox is highly contagious
“Smallpox has a slow transmission and is not highly contagious,” stated Joel Kuritsky, MD, director of the National Immunization Program and Early Smallpox Response and Planning at the CDC. This statement is a direct contradiction to nearly everything we have ever heard or read about smallpox. However, keep in mind that this comes “straight from the horse’s mouth” and should be considered the “real story” regarding how smallpox is spread.
Even if a person is exposed to a known bioterrorist attack with smallpox, it doesn’t mean that he will contract smallpox. The signs and symptoms of the disease will not occur immediately, and there is time to plan. The infection has an incubation period of 3 to 17 days,[i] and the first symptom will be the development of a high fever (>101º F), accompanied by nausea, vomiting, headache, severe abdominal cramping and low back pain. The person will be ill and most likely bed-ridden; not out mixing with the general public.
Even with a fever, it is critically important to realize that at this point the person is still not contagious. In fact, the fever may be caused by something else, such as the flu.
However, if a smallpox infection is developing, the characteristic rash will begin to develop within two to four days after the onset of the fever. The person becomes contagious and has the ability to spread the infection only after the development of the rash. “The characteristic rash of variola major is difficult to misdiagnose,” stated Walter A. Orenstein, M.D., Director of the National Immunization Program (NIP) at the CDC. The classic smallpox rash is a round, firm pustule that can spread and become confluent. The lesions are all in the same stage of development over the entire body and appear to be distributed more on the palms, soles and face than on the trunk or extremities.
ACTION ITEM: In the event of an exposure, it is imperative that you do everything you can to improve the functioning of your immune system so that an “exposure” does not have to result in an “outbreak.”
a. Stop eating all foods that contain refined white sugar products, since sugar inhibits the functioning of your white blood cells, your first line of defense.[ii]
(There are many other health-conscious dietary considerations to consider, but that is beyond the scope of this article.)
b. Start taking large doses of Vitamin C. Vitamin C has been proven in hundreds of studies to be effective in protecting the body from viral infections,[iii] including smallpox.[iv] For an extensive scientific review on the use of this nutrient and a “dosing recipe”, read “Vitamin C, The Master Nutrient, by Sandra Goodman, Ph.D. www.positivehealth.com/permit/Articles/Nutrition/vitcpre.htm
c. If you develop a fever, you still have time to plan. Purchase enough fresh, organic produce and filtered water to last three weeks. Move the kids to grandma’s or the neighbor’s house. Remember: YOU MAY NOT GET THE INFECTION AND YOU ARE NOT CONTAGIOUS UNTIL YOU GET THE RASH!
Myth 2: Smallpox is easily spread by casual contact with an infected person
Smallpox will not rapidly disseminate throughout the community. Even after the development of the rash, the infection is slow to spread. “The infection is spread by droplet contamination and coughing or sneezing are not generally part of the infection. Smallpox will not spread like wildfire,” said Orenstein. He stated that the spread of smallpox to casual contacts is the “exception to the rule.” Only 8% of cases in Africa were contracted by accidental contact.
Transmission of smallpox occurs only after intense contact, defined as “constant exposure of a person that is within 6-7 feet for a minimum of 6-7 days.”[v] Dr. Orenstein reported that in Africa, 92% of all cases came from close associations and in India, all cases came from prolonged personal contact. Dr. Tom Mack from the University of Southern California stated that in Pakistan, 27% of cases demonstrated no transmission to close associates. Nearly 37% had a transmission of only one generation, meaning that the second person to contract smallpox did not pass it onto the third person. These statistics directly contradict models that predict an exponential spread to millions.
Even without medical care, isolation was the best way to stop the spread of smallpox in Third World, population dense areas. With a slow transmission rate and an informed public, Mack estimated that the total number of smallpox cases in America would be less than 10, a far cry from the millions postulated by the press.
Dr. Kuritsky said at the CDC Public Forum on Smallpox on June 8 in St. Louis, “Given the slow transmission rate and that people need to be in close contact for nearly a week to spread the infection, the scenario in which a terrorist could infect himself with smallpox and contaminate an entire city by walking through the streets touching people is purely fiction.”
Point to ponder: Mass vaccination was halted in Third World countries because it didn’t work. In India, villages with an 88% vaccination rate still had outbreaks. After the World Health Organization began a surveillance and containment campaign, actively seeking cases of smallpox, isolating them in their homes, and vaccinating family members and close contacts, outbreaks were virtually eliminated within 2 years. The CDC and the WHO organization attribute the eradication of smallpox to the ring vaccination of close contacts. However, since the infection runs its course in 3-6 weeks, perhaps ISOLATION ALONE would have effectively accomplished the same thing.
Myth #3: The death rate from smallpox is 30%
Nearly every newspaper and journal article quotes this statistic. However, as pointed out in the presentation by Dr. Tom Mack, it appears that the “30% fatality rate” has come from skewed data. Dr. Mack has worked with smallpox extensively and saw more than 120 outbreaks in Pakistan throughout the early 1970s. Villages would apparently have “an importation” every 5-10 years, regardless of vaccination status, and the outbreak could always be predicated by living conditions and social arrangements. There were many small outbreaks and individual cases that never came to the attention of the local authorities.
Mack stated that even with poor medical care, the case fatality rate in adults was “much lower than is generally advertised” and thought to be 10-15%. He said that the statistics were “loaded with children that had a much higher fatality,” making the average death rate reported to be much higher. Amazingly, he revealed his opinion that even without mass vaccination, “smallpox would have died out anyway. It just would have taken longer.”
Even so, people died. Why? After all, smallpox is a skin disease and “other organs are seldom involved.”[vi] I posed this question to the committee on two separate occasions. Kathi Williams of the National Vaccine Information Center asked this question at the Institute of Medicine meeting on June 15th. On June 20, an answer was finally forthcoming when a member of the ACIP committee said, “That is a good question. Does anyone know the actual cause of death from smallpox?”
At that point, Dr. D.A. Henderson, from the John Hopkins University Department of Epidemiology volunteered a comment. Dr. Henderson directed the World Health Organization's global smallpox eradication campaign (1966-1977) and helped initiate WHO's global program of immunization in 1974. He approached the microphone and stated, “Well, it appears that the cause of death of smallpox is a ‘mystery.’” He stated that a medical resident had been asked to do a complete review of the literature and “not much information” was found. It is postulated that the people died from a “generalized toxemia” and that those with the most severe forms of smallpox—the hemorrhagic or confluent malignant types—died of complications of skin sloughing, similar to a burn. However, he concluded by saying, “it’s frustrating, because we don’t really know.”
COMMENT: I find this to be extremely frightening. If we knew why people died when they contracted smallpox, perhaps current medical technology could treat the complications, making the death rate much lower. Considering that the last known case of smallpox in the U.S. was in Texas in 1949, continuing to report that smallpox has a 30% death rate is similar to saying that all heart attacks are fatal. Based on 1949 technology, that would be accurate reporting. But in 2002, all heart attacks are NOT fatal. Neither would smallpox have a mortality rate of 30%.
Myth #4: There is no treatment for smallpox
A more accurate statement is “there are no pharmaceutical drugs for the treatment for smallpox.” But they are working on that too. There are 274 antiviral drug compounds and testing is underway to see if one can be useful in the treatment of smallpox.[vii] One such drug is called hexadecylosypropyl-cidofovir (HDP-CDV). Not yet available for human use, it has been found to be 100 times more potent than its cousin, cidofovir, a drug used to treat retinal infections in HIV patients. If studies pan out, HDP-CDV will be offered in a pill or capsule form over 5-14 days for the prevention and treatment of people exposed to smallpox.[viii] Unfortunately, this drug is being developed in Europe and will most likely be kept out of the US market until long after the general public has been subjected to mass vaccination.
It is important to note that there are several different presentations of a smallpox infection. The most common is called “ordinary discrete” smallpox, occurring in more than 40% of the cases. The outbreak is seen as a small scattering of pustules distributed across the body. The person with this type of smallpox needs minimal medical care and the reported death rate is <10%.[ix]
For mild cases of smallpox, adequate hydration and anti-fever products are essential for comfort and maintaining a temperature below 102ºF. Keeping the skin clean to prevent secondary bacterial infections is also important. A 1927 Textbook of Medicine recommends applying gauzed soaked in carbolic acid to “decrease itching and prevent extensive scarring.”[x] Carbolic acid is used acutely for burns that tend to ulcerate and other skin conditions that cause burning or prickling pain. Homeopathic forms of carbolic acid are also available.
For the severe complications of smallpox, modern day treatment options are available. The hemorrhagic type of smallpox, occurring in approximately 3% of cases, presents as hypotensive shock and can be treated accordingly. In another 3% of serious cases, the confluent-type has extensive skin involvement. These patients can be treated the same as a burn patient. All severe cases need to be treated for dehydration and watched for signs of bacterial suprainfection.
Research done by Dr. Peter Havens, MS, MD from the Medical College of Wisconsin postulated that death from smallpox was due to multisystem organ failure, a complication of an untreated acute cytokine (inflammatory) response. Massive oxidative stress occurs, leading to free-radical damage in the kidneys and other internal organs. However, Dr. Havens estimates that modern medical technology would indeed decrease the death rate, to possibly as low as 2-3%.
COMMENT: The treatment of choice for severe free-radical stress is high dose intravenous Vitamin C. If conventional medicine would recognize the value of this treatment, they would also be forced to realize mass vaccination is simply not necessary.
Treating severely ill patients would require hospitalization and unfortunately, smallpox spreads the most quickly in the hospital setting due to poor isolation techniques. In addition, most patients in hospitals are ill and immunosuppressed by disease or medication, making them more susceptible to infection. Dr. Mike Lane, former director of the CDC’s smallpox eradication program in the 1970s, said severely ill smallpox patients could be treated in a suburban motel or remote government building. “You can bring care to the patient if you elect to use the Motel 6 on the edge of town” rather than put smallpox victims in a hospital where the disease could spread to patients with weakened immune systems.
Side bar with Dr. Mike Lane:
Dr. Lane and I had a private conversation during a coffee break. During his presentation, he had been adamant that those within the “first ring” would need to be mandatorily vaccinated with 100% compliance. The “first ring” includes those that have had immediate, close contact with patients who had confirmed cases of smallpox. Lane stated that this was the only way that “ring vaccination would work.” When I questioned his definition of 100% compliance, he said, “Medical contraindications would not apply…there would be NO exceptions. I would rather vaccinate them and take my chances treating the potential complications. In India, we vaccinated everyone. The only medical contraindication was leprosy, and we sometimes vaccinated them. I’m sure that we killed a few people, but we did the best that we could.”
I pressed the issue further by saying, “if the death rate really is 30% (which I doubt), doesn’t that mean the survival rate is 70%? Shouldn’t that person have the right to play the odds with his health if he chose to?” His answer was the same: “If the person is exposed, there will be NO exceptions, medical or otherwise. Those people in the first ring—regardless of health status MUST be vaccinated.”
That means that all people with medical contraindictions—organ transplants, cancer, HIV, eczema and other skin conditions—would be vaccinated, even it was against their will and with the use of force, if necessary. He was quite the zealot about it; hopefully, in the event of a smallpox exposure, more reasonable minds will prevail.
Myth #5: The vaccine will keep me from getting the infection
Most people believe that all vaccines work to protect them, meaning that the vaccine will be clinically effective. What most people do not know is that vaccines have never been proven to protect them from getting the infection.
This little known fact is not only true for all vaccines, it is also true for the smallpox vaccine. Here are a few examples:
Chickenpox vaccine:
“No data exists regarding post-exposure efficacy of the current varicella vaccine.”
“Vaccinated persons have a less severe out break than unvaccinated”
(300 vs. 50 lesions.)[xi]
Pertussis vaccine:
"The findings of efficacy studies have not demonstrated a direct correlation between antibody response and protection against pertussis disease.”[xii]
Smallpox vaccine:
“Neutralizing antibodies are reported to reflect levels of protection, although this has not been validated in the field.” [xiii]
Dr. Harold Margolis, Senior Advisor to the Director for Smallpox Planning and Response, stated in Atlanta that “the vaccine decreased the death rate among those vaccinated by ‘modifying the disease’, not by preventing infection.”
TAKE HOME POINTS:
Smallpox is NOT highly contagious. You have time. Don’t panic.
Smallpox is only spread by close contact of less than 6 feet for at least 6-7 days. You aren’t that close to coworkers or commuters.
Treatment for smallpox should be surveillance and containment, without vaccination.
Smallpox is not highly fatal. There are treatments for smallpox.
The vaccine will not protect you from getting the infection. The vaccine has high complication rates, is an experimental drug and there are many contraindications. (Please see article at www.mercola.com/2002/jun/12/smallpox_update.htm )
Addendum:
As I was completing this report this morning, I read in the New York Times that the CDC plans to increase the number of “first responders” who receive the vaccination to 500,000 from the agreed-to 15,000.[xiv] Preparations are also underway for rapid mass vaccination of the general public. The more extensive vaccination plan is possible because supplies are increasing. As I have stated before, the government spent more than $780 million to develop its arsenal. Now that we have it, we will use it.
In addition to medical first responders, a presentation at the June 20th meeting suggested that first responders should also include a class to be defined as “economic first responders,” those who would be necessary in keeping the economy moving in the event of a nationwide “lock down” caused by an outbreak. This group would include pilots, truck drivers, food handlers, etc. It is the “etc.” that is of concern. Where do you draw the line? Obviously, the line will be drawn after Tommy Thompson’s vision of a “vaccine for every man, woman and child” has been fulfilled.
One of the major problems is the lack of vaccinia immune globulin (VIG), the “antidote” that is needed for those who experience a severe reaction to the vaccine. The Times article reports that there are only 700 doses currently available. Dr. Tom Mack, among others at the CDC warned that, “in the absence of VIG, extensive vaccination would be extremely dangerous.”
With the continued rhetoric about the US plans to go to war with Iraq, we are essentially taunting Saddam into launching a biological weapons attack on our own people. We are not given an exact knowledge as to Saddam’s capability but are given euphemisms such as “reasonably high” or “quite high.” But we don’t know for sure. And if the government knows, it is not telling. And if Saddam does have biological smallpox, what is the chance he has other weapons of biological destruction, those for which we do not have a vaccine?
We are developing “grounds” for a war with Iraq in spite of the rest of the world telling us to stay out of there. I encourage all to spend some time on this site: http://www.globalpolicy.org/ for some eye-opening information on policy that you won’t see in the popular press.
We are setting the stage for a health disaster unlike anything we have seen before in America, and it will be our own doing. World health records (England, Germany, Italy, the Philippines, British India, etc.) document that devastating epidemics followed mass vaccination. The worst smallpox disaster occurred in the Philippines after a 10 year compulsory US program administered 25 million vaccinations to its population of 10 million resulting in 170,000 cases and more than 75,000 deaths from ‘smallpox’, in a country having only scattered cases in rural villages prior to the onslaught of vaccines.[xv]
I received an excellent bulletin from Larken Rose (http://www.theft-by-deception.com)/ who is an activist regarding taxes. So much of what he said applies to the vaccine movement, that I got his permission to include part of his letter here. It is time to STAND AGAINST forced vaccination. Stop the hysteria! Information is power. However, after gaining power, you must ACT.
Here is something to inspire you:
More than 200 years ago, the people of this country chose to tell King George, not just that he was unreasonable, not just that they didn’t like him, not just that they had complaints about him, but that they were going to RESIST BY FORCE his tyrannical ways. The Declaration was not a threat to take King George to court; it was not a petition, or a request for fairness, or even a demand. It was a STATEMENT—a DECLARATION—that the people of America REFUSED TO TOLERATE the oppression, and were going to openly resist it, and didn’t give a damn what the King thought about it.
Though it may be politically incorrect to describe it this way, the Declaration of Independence was a bunch of people openly stating that they were going to IGNORE the law (not debate it or litigate it), and OVERTHROW their present government. (King George was not a foreign invader; he was "the government.") Again, in the words of the Declaration, "when a long train of abuses and usurpations, pursuing invariably the same object, evidences a design to reduce them under absolute despotism, it is the people’s right, it is their duty, to throw off such government."
Where are the Americans who still have that attitude?
There are a few (very few), and most people consider them to be "fringe extremists." Where do YOU draw the line? What injustice would government agents have to commit, before YOU would openly resist? Is there a line for you? Or would you complain and bicker all the way to absolute tyranny?
"Power concedes nothing without a demand. It never did, and it never will. Find out just what people will submit to, and you have found out the exact amount of injustice and wrong which will be imposed upon them, and these will continue till they have resisted with either words or blows, or with both. The limits of tyrants are prescribed by the endurance of those whom they suppress."
- Frederick Douglas-
This is a very different country today from what it was 226 years ago. We have become a country of sheep. We occasionally "baaa" at government injustice, but we do not ACT. For the most part, our “rebelliousness" now consists of pushing buttons in voting booths, to hopefully elect the less scummy of two lying scumbags (after a debate about which one is scummier).
For most people that is the extent of their resistance to government-imposed injustice. Each of us cowers in a corner for fear that we will be the next one that government makes an "example" of. While self-preservation is no sin, at some point a country of "self-preservers" will "preserve" itself into total submission to tyrants.
We are one step away from that now.
Once upon a time, a group of individuals declared to the world that they would fight and risk death, rather than tolerate the oppressions of an abusive government. Now, we are too comfortable for that. We are spoiled. We are cowards. For today’s battle, we need only the smallest fraction of the courage our forefathers demonstrated.
We do not need to lie in the mud, squinting in the cold to see the rifle sites, waiting for the glimpse of British Troops that we know are headed our way just over the next ridge. We do not need to run into the open field, in heavy enemy fire, to retrieve our buddy who just had his leg blown off by a cannonball.We do not need to leave our families and friends to fight, and possibly to die. No, today the price for our freedom (at least a huge chunk of it) is a pittance compared to what others have paid, but I have my doubts about whether we are willing to pay even that. What is that price? What do we need to do?
We need to just say NO by affirming the following:
I will avoid fear.
I will seek alternatives to the forced medical experimentation.
I will avoid being injected with an experimental new drug based on a “hunch” or based on something that happened hundreds or thousands of miles from where I live.
I will resist the government’s efforts to take away my right to do what I believe is best for my body.
I will take personal responsibility for my heath and for the health of my family.
Make sure to visit Sherri's Web Site: www.nmaseminars.com
[i] JAMA, June 9, 1999; Vol. 281, No. 22, p 3132
[ii] Bernstein J et al. Depression of lymphocyte transformation following oral glucose ingestion. Am. J. of Clin. Nut. 1977;30:613
[iii] Murata A. Virucidal Activity of Vitamin C: Vitamin C for Prevention and Treatment of Viral Diseases. Proceedings of the First Intersectional Congress of Microbiological Societies, Science Council of Japan 3:432-442. 1975.
[iv] Kligler IJ, Bernkopf H. Inactivation of Vaccinia Virus by Ascorbic Acid and Glutathione. Nature, vol. 139:pp.965-966. 1937
[v] Am. J. Epid. 1971; 91:316-326.
[vi] JAMA, June 9, 1999; Vol. 281, No. 22, p 2130
[vii] LeDuc, James and Jahrling, Peter B. Strengthening National Preparedness for Smallpox: an Update. Emerging Infectious Diseases, Jan-Feb 2001, Vol. 7., No. 1
[viii] Highfield, Roger. New drug could conquer smallpox, http://www.news.telegraph.co.uik/ 3-21-02.
[ix] Data from Rao, 1972, quoted in Fenner Table 1.2
[x] Blumgarten, A.S. “A Textbook of Medicine” for nursing students. 1927.
[xi] MMWR July 12, 1996/45(RR11); p. 12
[xii] MMWR March 28, 1997/Vol.46/No. RR-7, pg. 4
[xiii] JAMA, ibid. p 2131
[xiv] www.nytimes.com/2002/07/07/national/07SMAL.html?todaysheadlines
[xv] Physician William Howard Hay's address of June 25, 1937; printed in the Congressional Record.© 2002 http://www.nmaseminars.com/
http://www.ama-assn.org/sci-pubs/amnews/pick_01/hlsb1112.htm
Smallpox would have been wiped out completely across the planet forever had not the Federal government refused to destroy the remaining specimens used for military purposes. Which leads us to the question as to why smallpox even exists in weapon form since only a few nations had specimens from which to experiment with. My bet is that if a smallpox weapon exists, it originated from our own WMD programs. And if Saddam (or anyone else) has these types of weapons, we probably supplied him/them with them.
---max
Should Americans be immunized against the smallpox virus in case of a terrorist attack?
Officials with the U.S. Centers for Disease Control and Prevention say it's not necessary, yet 50 percent of citizens polled by ABCNEWS say they would still get the shot if and when the vaccine becomes available. We asked vaccine expert Dr. Steven Black to explain why nationwide smallpox vaccinations are not recommended.
Immunizations are among the most widely used and effective public health measures. Many immunizations in current use, including those for hepatitis B, polio and whooping cough, have been developed to replace earlier vaccines and provide a more acceptable safety profile.
Because of the continuous safety review process and the application of new technologies in vaccine development, the vaccines we currently use routinely are more effective against more diseases, and are safer than ever.
However, vaccines are not always without dangers.
The vaccine for smallpox was developed at the end of the 18th century and was last routinely used 30 years ago, in the 1970s, before the disease was eradicated worldwide in 1977. The vaccine provides protection against the dreaded risk of smallpox - a disease that killed one out of three people it infected and left most others with lifelong scars or disabilities.
Because of the high risk of smallpox disease and the limits of vaccine technology in the first half of the 20th century, people accepted the dangers associated with routine smallpox vaccination, which were more than outweighed by the ever-present threat of smallpox death.
Small, But Significant Risk of Death
Unfortunately, the smallpox vaccine is just not as safe as any of the other vaccines routinely used in the United States today.
The vaccine injection causes a red, tender and crusting reaction at the vaccination skin site that lasts up to two weeks.
More importantly, one out of 150,000 smallpox vaccination recipients experiences more severe reactions, including overwhelming infection due to the vaccine virus in individuals with abnormal immune systems, encephalitis or brain infection. Another one out of 500,000 individuals will die as a direct cause of the vaccine.
Although the risk of either death or these severe side effects may sound relatively rare, vaccination of the entire U.S. population would result in 600 deaths and 2,000 individuals with serious brain infections. These very real risks must be balanced against what is currently only a theoretical risk of smallpox being introduced by terrorists.
It works within a window. Variola goes "dormant" for a few weeks before breaking out into smallpox. If you can get an immediate response to vaccinia before the rash begins, the vaccine is very therapuetic. I'll have to track down the numbers, but in almost every case of exposure it has been beneficial to vaccinate most do not come down with the dz, and those that do have very mild symptoms, relatively speaking.
it takes 2 weeks after a vaccine for the antibody response to begin.
You begin to get an IgM response immediately, but it usually takes 2-3 days to get large measureable numbers, this is closely followed by an antibody switch to IgG (the antibody type most closes associated with immunological "memory"). After 5 days for most healthy adults you'll have the response necessary to fight variola if given the vaccine
Not panicking. But ...
This is really probably not necessary, and I don't suggest it. Although, I think if people want the vaccine and are in a position to pay for it, they should have access. The thing to remember, the smallpox vaccine is a LIVE virus, and there are dangers and complications associated with this particular vaccine over others commonly given, relatively speaking of course, and this is why we stopped vaccinating for variola on a regular basis in the ountry because some people did get sick and die. My point here being, that unless you have a REAL reason to seek out the vaccine, there no reason for even taking the small risk to get vaccinated.
Precautions and Contraindications
Before administering vaccinia vaccine, the physician should complete a thorough patient history to document the absence of vaccination contraindications among both vaccinees and their household contacts. Efforts should be made to identify vaccinees and their household contacts who have eczema, a history of eczema, or immunodeficiencies. Vaccinia vaccine should not be administered for routine nonemergency indications if these conditions are present among either recipients or their household contacts.
History or Presence of Eczema or Other Skin Conditions
Because of the increased risk for eczema vaccinatum, vaccinia vaccine should not be administered to persons with eczema of any degree, those with a past history of eczema, those whose household contacts have active eczema, or whose household contacts have a history of eczema. Persons with other acute, chronic, or exfoliative skin conditions (e.g., atopic dermatitis, burns, impetigo, or varicella zoster) might also be at higher risk for eczema vaccinatum and should not be vaccinated until the condition resolves.
Pregnancy
Live-viral vaccines are contraindicated during pregnancy; therefore, vaccinia vaccine should not be administered to pregnant women for routine nonemergency indications. However, vaccinia vaccine is not known to cause congenital malformations (63). Although <50 cases of fetal vaccinia infection have been reported, vaccinia virus has been reported to cause fetal infection on rare occasions, almost always after primary vaccination of the mother (64). Cases have been reported as recently as 1978 (55,65). When fetal vaccinia does occur, it usually results in stillbirth or death of the infant soon after delivery.
Altered Immunocompetence
Replication of vaccinia virus can be enhanced among persons with immunodeficiency diseases and among those with immunosuppression (e.g., as occurs with leukemia, lymphoma, generalized malignancy, solid organ transplantation, cellular or humoral immunity disorders, or therapy with alkylating agents, antimetabolites, radiation, or high-dose corticosteroid therapy [i.e., >2 mg/kg body weight or 20 mg/day of prednisone for >2 weeks] [66]). Persons with immunosuppression also include hematopoietic stem cell transplant recipients who are <24 months posttransplant, and hematopoietic stem cell transplant recipients who are >24 months posttransplant but who have graft-versus-host disease or disease relapse. Persons with such conditions or whose household contacts have such conditions should not be administered vaccinia vaccine.
Persons Infected with HIV
Risk for severe complications after vaccinia vaccination for persons infected with HIV is unknown. One case of severe generalized vaccinia has been reported involving an asymptomatic HIV-infected military recruit after the administration of multiple vaccines that included vaccinia vaccine (58). Additionally, a 1991 report indicated that two HIV-infected persons might have died of a progressive vaccinia-like illness after treatment with inactivated autologous lymphocytes infected with a recombinant HIV-vaccinia virus (67). No evidence exists that smallpox vaccination accelerates the progression of HIV-related disease. However, the degree of immunosuppression that would place an HIV-infected person at greater risk for adverse events is unknown. Because of this uncertainty, until additional information becomes available, not vaccinating persons (under routine nonemergency conditions) who have HIV infection is advisable.
Infants and Children
Before the eradication of smallpox, vaccinia vaccination was administered routinely during childhood. However, smallpox vaccination is no longer indicated for infants or children for routine nonemergency indications.
Persons with Allergies to Vaccine Components
The currently available vaccinia vaccine (i.e., Dryvax) contains trace amounts of polymyxin B sulfate, streptomycin sulfate, chlortetracycline hydrochloride, and neomycin sulfate. Persons who experience anaphylactic reactions (i.e., hives, swelling of the mouth and throat, difficulty breathing, hypotension, and shock) to any of these antibiotics should not be vaccinated.
[I AM ALLERGIC TO SEVERAL OF THE MENTIONED DRUGS ABOVE, and have had hives and been hospitalized due to them. Plus, my son and I have eczema].
Vaccinia vaccine does not contain penicillin. Future supplies of vaccinia vaccine will be reformulated and might contain other preservatives or stabilizers. Refer to the manufacturer's package insert for additional information
Absolute quarantine means physical partitioning and isolation of a sufficient radius around the patient to minimize even casual risk. In plain English if the patient is discovered in Upper Manhattan, a 50 mile radius around the patient will be isolated by civil or military authorities.
In addition the proposed plan calls for a national, involutary curtailment of travel outside the area were you are located (not necessarily your home) at the time the emergency is declared.
So for you folks who plan to "head for the hills" rather than your doctor's office the hills are out if they are not within walking distance.
That may work if you know immediately that you were exposed to someone with smallpox and could try to get your immunity up before the virus has spread through your body (or your kids'), but if you only realize it when you start seeing the blisters, it would be too late. I think I'll stay with the idea of getting my kids out of the country for a while and into some remote area where there aren't many people. I can do that unless they block us from leaving.
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