The whole notion of one and no more is more a caution of physcians dreading lawsuits than anything else, since the anti-coagulant function is proportional to the blood volume of your body which is why a baby aspirin may be little more than a placebo.
However, it is well understood that aspirin does cause stomach bleeding; doctors are reluctant to recommend what they themselves know to be the optimum dose.
I take four at a time dissolved in water with 1/4 tsp of baking soda and 6 oz of water to flush (best on a full stomach as a preventive.)
I am not a doctor and I don't even watch T.V. unless you count Andy Griffith and Wheel of Fortune.
No, I disagree. The cost of aspirin is low enough, even for name brands which will provide more reliable dissolving and consistency