Hamilton didn't explain to his interlocutors that anyone bent on "acts of usurpation" would also probably have control of the national defense establishment, and call it down on the protesting societies if they tried to dismiss the usurpatory acts.
Imagine the State of Georgia attempting to resist a Congressional bill directly attainting a situation in Georgia and settling things to Congress's own satisfaction, nowadays. One has to think that Hamilton knew how that one would work out......and that his blandishments were just that, a siren song for people uneasy about strong government. He understood deeply their misgivings, "felt their pain".......and didn't give a damn. He had to make things right for the Downtown Boys. Who are nowadays the Wall Street Wing of the GOP.
When Chisholm v Georgia was handed down (before the 11th existed, and contrary to assurances by federalists that such cases could legally occur), the state passed legislation that made it illegal for a state officials to comply with the decision. The penalty was immediate execution, without the benefit of attending clergy. The states did resist the unconstitutional actions of the federal behemouth. I can imagine it, and would like to see the states regain their constitutional powers.